Advanced search
Add to list

Live-food mediated drug delivery as a tool for disease treatment in larviculture : the enrichment of therapeutics in rotifers and Artemia nauplii

(1992) AQUACULTURAL ENGINEERING. 11(2). p.133-139
Author
Organization
Abstract
The live food enrichment technique using emulsions for correcting nutritional deficiencies in rotifers and Artemia was further investigated as a tool for transferring therapeutics through the food chain. Artemia nauplii and the rotifer Brachionus plicatilis were enriched with a self-emulsifying concentrate in which the therapeutic mixture trimethoprim: sulfamethoxazole was incorporated. An analytical method and protocol for the quantification of trimethoprim and sulfamethoxazole in a heterogeneous biological matrix, such as Artemia, was developed using High Performance Liquid Chromatography. When applying a 24-h enrichment period, the accumulation of both drugs in Artemia nauplii appeared to be linearly related to the concentration of the drugs in the enrichment product. Values of approximately 790 mg/kg of total drugs (protein basis; or 290 mg/kg on dry weight basis) could be obtained. In rotifers, the level of total therapeutics reached a value of about 116 mg/kg (protein basis) after 6 h of enrichment. The ratio of the two drugs detected in rotifers was different from the one found in Artemia, suggesting different accumulation kinetics.

Citation

Please use this url to cite or link to this publication:

MLA
Verpraet, Rini, Mohammed Chair, Philipe Léger, et al. “Live-food Mediated Drug Delivery as a Tool for Disease Treatment in Larviculture : the Enrichment of Therapeutics in Rotifers and Artemia Nauplii.” AQUACULTURAL ENGINEERING 11.2 (1992): 133–139. Print.
APA
Verpraet, R., Chair, M., Léger, P., Nelis, H., Sorgeloos, P., & De Leenheer, A. (1992). Live-food mediated drug delivery as a tool for disease treatment in larviculture : the enrichment of therapeutics in rotifers and Artemia nauplii. AQUACULTURAL ENGINEERING, 11(2), 133–139.
Chicago author-date
Verpraet, Rini, Mohammed Chair, Philipe Léger, Hans Nelis, Patrick Sorgeloos, and Andreas De Leenheer. 1992. “Live-food Mediated Drug Delivery as a Tool for Disease Treatment in Larviculture : the Enrichment of Therapeutics in Rotifers and Artemia Nauplii.” Aquacultural Engineering 11 (2): 133–139.
Chicago author-date (all authors)
Verpraet, Rini, Mohammed Chair, Philipe Léger, Hans Nelis, Patrick Sorgeloos, and Andreas De Leenheer. 1992. “Live-food Mediated Drug Delivery as a Tool for Disease Treatment in Larviculture : the Enrichment of Therapeutics in Rotifers and Artemia Nauplii.” Aquacultural Engineering 11 (2): 133–139.
Vancouver
1.
Verpraet R, Chair M, Léger P, Nelis H, Sorgeloos P, De Leenheer A. Live-food mediated drug delivery as a tool for disease treatment in larviculture : the enrichment of therapeutics in rotifers and Artemia nauplii. AQUACULTURAL ENGINEERING. 1992;11(2):133–9.
IEEE
[1]
R. Verpraet, M. Chair, P. Léger, H. Nelis, P. Sorgeloos, and A. De Leenheer, “Live-food mediated drug delivery as a tool for disease treatment in larviculture : the enrichment of therapeutics in rotifers and Artemia nauplii,” AQUACULTURAL ENGINEERING, vol. 11, no. 2, pp. 133–139, 1992.
@article{228688,
  abstract     = {The live food enrichment technique using emulsions for correcting nutritional deficiencies in rotifers and Artemia was further investigated as a tool for transferring therapeutics through the food chain. Artemia nauplii and the rotifer Brachionus plicatilis were enriched with a self-emulsifying concentrate in which the therapeutic mixture trimethoprim: sulfamethoxazole was incorporated. An analytical method and protocol for the quantification of trimethoprim and sulfamethoxazole in a heterogeneous biological matrix, such as Artemia, was developed using High Performance Liquid Chromatography. When applying a 24-h enrichment period, the accumulation of both drugs in Artemia nauplii appeared to be linearly related to the concentration of the drugs in the enrichment product. Values of approximately 790 mg/kg of total drugs (protein basis; or 290 mg/kg on dry weight basis) could be obtained. In rotifers, the level of total therapeutics reached a value of about 116 mg/kg (protein basis) after 6 h of enrichment. The ratio of the two drugs detected in rotifers was different from the one found in Artemia, suggesting different accumulation kinetics.},
  author       = {Verpraet, Rini and Chair, Mohammed and Léger, Philipe and Nelis, Hans and Sorgeloos, Patrick and De Leenheer, Andreas},
  issn         = {0144-8609},
  journal      = {AQUACULTURAL ENGINEERING},
  language     = {eng},
  number       = {2},
  pages        = {133--139},
  title        = {Live-food mediated drug delivery as a tool for disease treatment in larviculture : the enrichment of therapeutics in rotifers and Artemia nauplii},
  url          = {http://dx.doi.org/10.1016/0144-8609(92)90015-P},
  volume       = {11},
  year         = {1992},
}

Altmetric
View in Altmetric