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Absence of functional renal effects of uro-angiographic contrast-media on post-ischemic rat kidneys

(1991) ACTA RADIOLOGICA. 32(4). p.325-328
Author
Organization
Abstract
Water soluble ionic contrast media (CM) and glucose 5% were administered to Sprague-Dawley rats 36 hours after bilateral warm renal ischemia for 45 min. In all animals (n = 28) the renal ischemia caused a decrease of the absolute urinary creatinine output. Intraarterial injection of glucose 5% or CM did not produce different patterns of absolute urinary creatinine output. The serum creatinine increased after 36 hours of reflow. When compared by means of a Mann-Whitney U-test to a normal median serum creatinine obtained in a separate group of 22 normal rats, the increase was statistically significant (p less-than-or-equal-to 0.01). The serum creatinine medians returned to a normal level after 24 hours. It seems therefore that 45 min of warm renal ischemia and 36 hours of reflow is an insufficient challenge to the rat kidney for the detection of the nephrotoxic properties of CM as opposed to when CM are injected during ischemia.
Keywords
FAILURE, ARTERIAL-OCCLUSION, NEPHROTOXICITY, CONTRAST MEDIA, EXPERIMENTAL STUDIES, TOXICITY, KIDNEY, ISCHEMIA

Citation

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MLA
Verbaeys, Antony, GEORGES VAN MAELE, Walter De Sy, et al. “Absence of Functional Renal Effects of Uro-angiographic Contrast-media on Post-ischemic Rat Kidneys.” ACTA RADIOLOGICA 32.4 (1991): 325–328. Print.
APA
Verbaeys, A., VAN MAELE, G., De Sy, W., Ringoir, S., & Lameire, N. (1991). Absence of functional renal effects of uro-angiographic contrast-media on post-ischemic rat kidneys. ACTA RADIOLOGICA, 32(4), 325–328.
Chicago author-date
Verbaeys, Antony, GEORGES VAN MAELE, Walter De Sy, S Ringoir, and Norbert Lameire. 1991. “Absence of Functional Renal Effects of Uro-angiographic Contrast-media on Post-ischemic Rat Kidneys.” Acta Radiologica 32 (4): 325–328.
Chicago author-date (all authors)
Verbaeys, Antony, GEORGES VAN MAELE, Walter De Sy, S Ringoir, and Norbert Lameire. 1991. “Absence of Functional Renal Effects of Uro-angiographic Contrast-media on Post-ischemic Rat Kidneys.” Acta Radiologica 32 (4): 325–328.
Vancouver
1.
Verbaeys A, VAN MAELE G, De Sy W, Ringoir S, Lameire N. Absence of functional renal effects of uro-angiographic contrast-media on post-ischemic rat kidneys. ACTA RADIOLOGICA. 1991;32(4):325–8.
IEEE
[1]
A. Verbaeys, G. VAN MAELE, W. De Sy, S. Ringoir, and N. Lameire, “Absence of functional renal effects of uro-angiographic contrast-media on post-ischemic rat kidneys,” ACTA RADIOLOGICA, vol. 32, no. 4, pp. 325–328, 1991.
@article{225618,
  abstract     = {Water soluble ionic contrast media (CM) and glucose 5% were administered to Sprague-Dawley rats 36 hours after bilateral warm renal ischemia for 45 min. In all animals (n = 28) the renal ischemia caused a decrease of the absolute urinary creatinine output. Intraarterial injection of glucose 5% or CM did not produce different patterns of absolute urinary creatinine output. The serum creatinine increased after 36 hours of reflow. When compared by means of a Mann-Whitney U-test to a normal median serum creatinine obtained in a separate group of 22 normal rats, the increase was statistically significant (p less-than-or-equal-to 0.01). The serum creatinine medians returned to a normal level after 24 hours. It seems therefore that 45 min of warm renal ischemia and 36 hours of reflow is an insufficient challenge to the rat kidney for the detection of the nephrotoxic properties of CM as opposed to when CM are injected during ischemia.},
  author       = {Verbaeys, Antony and VAN MAELE, GEORGES and De Sy, Walter and Ringoir, S and Lameire, Norbert},
  issn         = {0284-1851},
  journal      = {ACTA RADIOLOGICA},
  keywords     = {FAILURE,ARTERIAL-OCCLUSION,NEPHROTOXICITY,CONTRAST MEDIA,EXPERIMENTAL STUDIES,TOXICITY,KIDNEY,ISCHEMIA},
  language     = {eng},
  number       = {4},
  pages        = {325--328},
  title        = {Absence of functional renal effects of uro-angiographic contrast-media on post-ischemic rat kidneys},
  volume       = {32},
  year         = {1991},
}