Advanced search
Add to list

Verification of a formula for determination of preexcision surgical margins from fixed-tissue melanoma specimens

Author
Organization
Abstract
Background. Recently our group reported on the shrinkage of 199 malignant melanoma surgical-excision specimens. In that report, a multivariate analysis revealed that the age of the patient was the only factor that significantly affected the percentage shrinkage of a surgical specimen. In addition, a formula was presented that extrapolates the actual surgical margins (in vivo) from the (contracted) fixed-tissue pathology report measurement and the reported in vivo lesion diameter. Objective. The goals of this study are to verify that shrinkage of surgical specimens is approximately 20% and that the margin formula can be successfully applied to a different group of patients. Methods: Four hundred seven patients with malignant melanoma were prospectively enrolled to measure preexcision (outlined with ink) surgical margins, fixed-tissue (contracted) surgical margins, and overall specimen shrinkage. Results. It is verified that overall shrinkage of cutaneous surgical specimens is approximately 20%. Surgical specimens from patients younger than 50 years of age have approximately 25% shrinkage. Those specimens from patients 50 to 59 years of age have approximately 20% shrinkage and those from patients 60 years of age or older have about 15% shrinkage. The surgical margins predicted by the margin formula were within +/- 3.5 mm of the actual measured surgical margin 86.5% of the time. Conclusion: The actual surgical margins (in vivo) of a malignant melanoma can be reasonably estimated from the fixed-tissue pathology measurement via the margin formula. The shrinkage of a surgical specimen is 15% to 25% depending on the patient's age.
Keywords
OPTIMAL RESECTION MARGIN, CUTANEOUS MALIGNANT-MELANOMA, MANAGEMENT, GUIDE

Citation

Please use this url to cite or link to this publication:

MLA
Silverman, MK, FM Golomb, AW Kopf, et al. “Verification of a Formula for Determination of Preexcision Surgical Margins from Fixed-tissue Melanoma Specimens.” JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 27.2 (1) (1992): 214–219. Print.
APA
Silverman, M., Golomb, F., Kopf, A., Grin, C., Vossaert, K., Doyle, J., & Levenstein, M. (1992). Verification of a formula for determination of preexcision surgical margins from fixed-tissue melanoma specimens. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 27(2 (1)), 214–219.
Chicago author-date
Silverman, MK, FM Golomb, AW Kopf, CM Grin, Katrien Vossaert, JP Doyle, and MJ Levenstein. 1992. “Verification of a Formula for Determination of Preexcision Surgical Margins from Fixed-tissue Melanoma Specimens.” Journal of the American Academy of Dermatology 27 (2 (1)): 214–219.
Chicago author-date (all authors)
Silverman, MK, FM Golomb, AW Kopf, CM Grin, Katrien Vossaert, JP Doyle, and MJ Levenstein. 1992. “Verification of a Formula for Determination of Preexcision Surgical Margins from Fixed-tissue Melanoma Specimens.” Journal of the American Academy of Dermatology 27 (2 (1)): 214–219.
Vancouver
1.
Silverman M, Golomb F, Kopf A, Grin C, Vossaert K, Doyle J, et al. Verification of a formula for determination of preexcision surgical margins from fixed-tissue melanoma specimens. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. 1992;27(2 (1)):214–9.
IEEE
[1]
M. Silverman et al., “Verification of a formula for determination of preexcision surgical margins from fixed-tissue melanoma specimens,” JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 27, no. 2 (1), pp. 214–219, 1992.
@article{225286,
  abstract     = {{Background. Recently our group reported on the shrinkage of 199 malignant melanoma surgical-excision specimens. In that report, a multivariate analysis revealed that the age of the patient was the only factor that significantly affected the percentage shrinkage of a surgical specimen. In addition, a formula was presented that extrapolates the actual surgical margins (in vivo) from the (contracted) fixed-tissue pathology report measurement and the reported in vivo lesion diameter. 
Objective. The goals of this study are to verify that shrinkage of surgical specimens is approximately 20% and that the margin formula can be successfully applied to a different group of patients. Methods: Four hundred seven patients with malignant melanoma were prospectively enrolled to measure preexcision (outlined with ink) surgical margins, fixed-tissue (contracted) surgical margins, and overall specimen shrinkage. Results. It is verified that overall shrinkage of cutaneous surgical specimens is approximately 20%. Surgical specimens from patients younger than 50 years of age have approximately 25% shrinkage. Those specimens from patients 50 to 59 years of age have approximately 20% shrinkage and those from patients 60 years of age or older have about 15% shrinkage. The surgical margins predicted by the margin formula were within +/- 3.5 mm of the actual measured surgical margin 86.5% of the time. 
Conclusion: The actual surgical margins (in vivo) of a malignant melanoma can be reasonably estimated from the fixed-tissue pathology measurement via the margin formula. The shrinkage of a surgical specimen is 15% to 25% depending on the patient's age.}},
  author       = {{Silverman, MK and Golomb, FM and Kopf, AW and Grin, CM and Vossaert, Katrien and Doyle, JP and Levenstein, MJ}},
  issn         = {{0190-9622}},
  journal      = {{JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY}},
  keywords     = {{OPTIMAL RESECTION MARGIN,CUTANEOUS MALIGNANT-MELANOMA,MANAGEMENT,GUIDE}},
  language     = {{eng}},
  number       = {{2 (1)}},
  pages        = {{214--219}},
  title        = {{Verification of a formula for determination of preexcision surgical margins from fixed-tissue melanoma specimens}},
  url          = {{http://dx.doi.org/10.1016/0190-9622(92)70173-D}},
  volume       = {{27}},
  year         = {{1992}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: