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Growth-behavior of human pancreatic-carcinoma xenograft correlates with nuclear features

H Coen, H Kint, C Kuijper, G Jonges, N Dumarey, M Pauwels, G Kloppel and Frank Roels (1992) CYTOMETRY. 13(7). p.775-781
abstract
Two human pancreatic ductal adenocarcinomas with different growth rates were serially transplanted into nude mice. Feulgen-stained 4-mu-m sections and imprints from the xenografts were studied with a VICOM automated image analysis system. After pooling the results from two passages, with three mice in each passage, it was shown that of 23 nuclear parameters measured the following were correlated with a fast tumor growth rate: in sections, a decrease in heterogeneity of the chromatin and an increase in perimeter and nuclear area; in imprints, an increase in lesser diameter, in mean grey level difference between second neighboring pixels, and in total integrated optical density (DNA content). Several parameters differed significantly between passages, and between animals in the same passage. These findings suggest that the growth speed of pancreatic tumors may be predicted by nuclear parameters.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ADENOCARCINOMAS, KINETICS, DNA CONTENT, PROGNOSIS, CANCER, TISSUE-SECTIONS, MICE, NUCLEAR PARAMETERS, IMAGE ANALYSIS, GROWTH RATE, PANCREATIC CARCINOMA XENOGRAFT, SIZE, PLOIDY
journal title
CYTOMETRY
Cytometry
volume
13
issue
7
pages
775 - 781
Web of Science type
Article
ISSN
0196-4763
DOI
10.1002/cyto.990130714
language
English
UGent publication?
yes
classification
A1
id
224267
handle
http://hdl.handle.net/1854/LU-224267
date created
2004-05-24 13:24:00
date last changed
2016-12-19 15:38:51
@article{224267,
  abstract     = {Two human pancreatic ductal adenocarcinomas with different growth rates were serially transplanted into nude mice. Feulgen-stained 4-mu-m sections and imprints from the xenografts were studied with a VICOM automated image analysis system. After pooling the results from two passages, with three mice in each passage, it was shown that of 23 nuclear parameters measured the following were correlated with a fast tumor growth rate: in sections, a decrease in heterogeneity of the chromatin and an increase in perimeter and nuclear area; in imprints, an increase in lesser diameter, in mean grey level difference between second neighboring pixels, and in total integrated optical density (DNA content). Several parameters differed significantly between passages, and between animals in the same passage. These findings suggest that the growth speed of pancreatic tumors may be predicted by nuclear parameters.},
  author       = {Coen, H and Kint, H and Kuijper, C and Jonges, G and Dumarey, N and Pauwels, M and Kloppel, G and Roels, Frank},
  issn         = {0196-4763},
  journal      = {CYTOMETRY},
  keyword      = {ADENOCARCINOMAS,KINETICS,DNA CONTENT,PROGNOSIS,CANCER,TISSUE-SECTIONS,MICE,NUCLEAR PARAMETERS,IMAGE ANALYSIS,GROWTH RATE,PANCREATIC CARCINOMA XENOGRAFT,SIZE,PLOIDY},
  language     = {eng},
  number       = {7},
  pages        = {775--781},
  title        = {Growth-behavior of human pancreatic-carcinoma xenograft correlates with nuclear features},
  url          = {http://dx.doi.org/10.1002/cyto.990130714},
  volume       = {13},
  year         = {1992},
}

Chicago
Coen, H, H Kint, C Kuijper, G Jonges, N Dumarey, M Pauwels, G Kloppel, and Frank Roels. 1992. “Growth-behavior of Human Pancreatic-carcinoma Xenograft Correlates with Nuclear Features.” Cytometry 13 (7): 775–781.
APA
Coen, H., Kint, H., Kuijper, C., Jonges, G., Dumarey, N., Pauwels, M., Kloppel, G., et al. (1992). Growth-behavior of human pancreatic-carcinoma xenograft correlates with nuclear features. CYTOMETRY, 13(7), 775–781.
Vancouver
1.
Coen H, Kint H, Kuijper C, Jonges G, Dumarey N, Pauwels M, et al. Growth-behavior of human pancreatic-carcinoma xenograft correlates with nuclear features. CYTOMETRY. 1992;13(7):775–81.
MLA
Coen, H, H Kint, C Kuijper, et al. “Growth-behavior of Human Pancreatic-carcinoma Xenograft Correlates with Nuclear Features.” CYTOMETRY 13.7 (1992): 775–781. Print.