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Growth-behavior of human pancreatic-carcinoma xenograft correlates with nuclear features

(1992) CYTOMETRY. 13(7). p.775-781
Author
Organization
Abstract
Two human pancreatic ductal adenocarcinomas with different growth rates were serially transplanted into nude mice. Feulgen-stained 4-mu-m sections and imprints from the xenografts were studied with a VICOM automated image analysis system. After pooling the results from two passages, with three mice in each passage, it was shown that of 23 nuclear parameters measured the following were correlated with a fast tumor growth rate: in sections, a decrease in heterogeneity of the chromatin and an increase in perimeter and nuclear area; in imprints, an increase in lesser diameter, in mean grey level difference between second neighboring pixels, and in total integrated optical density (DNA content). Several parameters differed significantly between passages, and between animals in the same passage. These findings suggest that the growth speed of pancreatic tumors may be predicted by nuclear parameters.
Keywords
ADENOCARCINOMAS, KINETICS, DNA CONTENT, PROGNOSIS, CANCER, TISSUE-SECTIONS, MICE, NUCLEAR PARAMETERS, IMAGE ANALYSIS, GROWTH RATE, PANCREATIC CARCINOMA XENOGRAFT, SIZE, PLOIDY

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Chicago
Coen, H, H Kint, C Kuijper, G Jonges, N Dumarey, M Pauwels, G Kloppel, and Frank Roels. 1992. “Growth-behavior of Human Pancreatic-carcinoma Xenograft Correlates with Nuclear Features.” Cytometry 13 (7): 775–781.
APA
Coen, H, Kint, H., Kuijper, C., Jonges, G., Dumarey, N., Pauwels, M., Kloppel, G., et al. (1992). Growth-behavior of human pancreatic-carcinoma xenograft correlates with nuclear features. CYTOMETRY, 13(7), 775–781.
Vancouver
1.
Coen H, Kint H, Kuijper C, Jonges G, Dumarey N, Pauwels M, et al. Growth-behavior of human pancreatic-carcinoma xenograft correlates with nuclear features. CYTOMETRY. 1992;13(7):775–81.
MLA
Coen, H, H Kint, C Kuijper, et al. “Growth-behavior of Human Pancreatic-carcinoma Xenograft Correlates with Nuclear Features.” CYTOMETRY 13.7 (1992): 775–781. Print.
@article{224267,
  abstract     = {Two human pancreatic ductal adenocarcinomas with different growth rates were serially transplanted into nude mice. Feulgen-stained 4-mu-m sections and imprints from the xenografts were studied with a VICOM automated image analysis system. After pooling the results from two passages, with three mice in each passage, it was shown that of 23 nuclear parameters measured the following were correlated with a fast tumor growth rate: in sections, a decrease in heterogeneity of the chromatin and an increase in perimeter and nuclear area; in imprints, an increase in lesser diameter, in mean grey level difference between second neighboring pixels, and in total integrated optical density (DNA content). Several parameters differed significantly between passages, and between animals in the same passage. These findings suggest that the growth speed of pancreatic tumors may be predicted by nuclear parameters.},
  author       = {Coen, H and Kint, H and Kuijper, C and Jonges, G and Dumarey, N and Pauwels, M and Kloppel, G and Roels, Frank},
  issn         = {0196-4763},
  journal      = {CYTOMETRY},
  keyword      = {ADENOCARCINOMAS,KINETICS,DNA CONTENT,PROGNOSIS,CANCER,TISSUE-SECTIONS,MICE,NUCLEAR PARAMETERS,IMAGE ANALYSIS,GROWTH RATE,PANCREATIC CARCINOMA XENOGRAFT,SIZE,PLOIDY},
  language     = {eng},
  number       = {7},
  pages        = {775--781},
  title        = {Growth-behavior of human pancreatic-carcinoma xenograft correlates with nuclear features},
  url          = {http://dx.doi.org/10.1002/cyto.990130714},
  volume       = {13},
  year         = {1992},
}

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