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Proceeding with clinical trials of animal to human organ transplantation: a way out of the dilemma

An Ravelingien UGent, Freddy Mortier UGent, Eric Mortier UGent, ILSE KERREMANS and Johan Braeckman UGent (2004) JOURNAL OF MEDICAL ETHICS. 30(1). p.92-98
abstract
The transplantation of porcine organs to humans could in the future be a solution to the worldwide organ shortage, but is to date still highly experimental. Further research on the potential effects of crossing the species barrier is essential before clinical application is acceptable. However, many crucial questions on efficacy and safety will ultimately only be answered by well designed and controlled solid organ xenotransplantation trials on humans. This paper is concerned with the question under which conditions, given the risks involved and the ethical issues raised, such clinical trials should be resumed. An alternative means of overcoming the safety and ethical issues is suggested: willed body donation for scientific research in the case of permanent vegetative status. This paper argues that conducting trials on such bodies with prior consent is preferable to the use of human subjects without lack of brain function.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PORCINE ENDOGENOUS RETROVIRUS, PERSISTENT VEGETATIVE STATE, NO EVIDENCE, MEDICAL ASPECTS, HUMAN-CELLS, NEWLY DEAD, XENOTRANSPLANTATION, INFECTION, BRAIN, PIGS
journal title
JOURNAL OF MEDICAL ETHICS
J. Med. Ethics
volume
30
issue
1
pages
92 - 98
Web of Science type
Article
Web of Science id
000188856900020
JCR category
ETHICS
JCR impact factor
1.353 (2004)
JCR rank
2/28 (2004)
JCR quartile
1 (2004)
ISSN
0306-6800
DOI
10.1136/jme.2003.004325
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
218374
handle
http://hdl.handle.net/1854/LU-218374
date created
2004-05-18 11:08:00
date last changed
2016-12-19 15:43:52
@article{218374,
  abstract     = {The transplantation of porcine organs to humans could in the future be a solution to the worldwide organ shortage, but is to date still highly experimental. Further research on the potential effects of crossing the species barrier is essential before clinical application is acceptable. However, many crucial questions on efficacy and safety will ultimately only be answered by well designed and controlled solid organ xenotransplantation trials on humans. This paper is concerned with the question under which conditions, given the risks involved and the ethical issues raised, such clinical trials should be resumed. An alternative means of overcoming the safety and ethical issues is suggested: willed body donation for scientific research in the case of permanent vegetative status. This paper argues that conducting trials on such bodies with prior consent is preferable to the use of human subjects without lack of brain function.},
  author       = {Ravelingien, An and Mortier, Freddy and Mortier, Eric and KERREMANS, ILSE and Braeckman, Johan},
  issn         = {0306-6800},
  journal      = {JOURNAL OF MEDICAL ETHICS},
  keyword      = {PORCINE ENDOGENOUS RETROVIRUS,PERSISTENT VEGETATIVE STATE,NO EVIDENCE,MEDICAL ASPECTS,HUMAN-CELLS,NEWLY DEAD,XENOTRANSPLANTATION,INFECTION,BRAIN,PIGS},
  language     = {eng},
  number       = {1},
  pages        = {92--98},
  title        = {Proceeding with clinical trials of animal to human organ transplantation: a way out of the dilemma},
  url          = {http://dx.doi.org/10.1136/jme.2003.004325},
  volume       = {30},
  year         = {2004},
}

Chicago
Ravelingien, An, Freddy Mortier, Eric Mortier, Ilse Kerremans, and Johan Braeckman. 2004. “Proceeding with Clinical Trials of Animal to Human Organ Transplantation: a Way Out of the Dilemma.” Journal of Medical Ethics 30 (1): 92–98.
APA
Ravelingien, A., Mortier, F., Mortier, E., Kerremans, I., & Braeckman, J. (2004). Proceeding with clinical trials of animal to human organ transplantation: a way out of the dilemma. JOURNAL OF MEDICAL ETHICS, 30(1), 92–98.
Vancouver
1.
Ravelingien A, Mortier F, Mortier E, Kerremans I, Braeckman J. Proceeding with clinical trials of animal to human organ transplantation: a way out of the dilemma. JOURNAL OF MEDICAL ETHICS. 2004;30(1):92–8.
MLA
Ravelingien, An, Freddy Mortier, Eric Mortier, et al. “Proceeding with Clinical Trials of Animal to Human Organ Transplantation: a Way Out of the Dilemma.” JOURNAL OF MEDICAL ETHICS 30.1 (2004): 92–98. Print.