Advanced search
1 file | 150.60 KB

Is central benzodiazepine receptor imaging useful for the identification of epileptogenic foci in localization-related epilepsies?

Ingeborg Goethals (UGent) , Christophe Van De Wiele (UGent) , Paul Boon (UGent) and Rudi Dierckx (UGent)
Author
Organization
Abstract
In the presurgical evaluation of patients with partial epilepsies, the most extensively studied functional neuro-imaging modality to define the origin of seizure onset is fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET). Generally, this technique reveals a widespread zone of interictal glucose hypometabolism in the region of the epileptogenic focus. However, the technique may miss the epileptogenic region and FDG PET abnormalities may extend beyond the seizure onset zone. Consequently, for the precise identification of epileptogenic regions more specific imaging probes than FDG are warranted. This review considers the clinical utility of iomazenil (IMZ) SPET and flumazenil (FMZ) PET for the precise localization of epileptogenic foci in partial epilepsy syndromes.
Keywords
epileptogenic foci, C-11 FLUMAZENIL PET, I-123 IOMAZENIL-SPECT, partial epilepsy syndromes, HIPPOCAMPAL SCLEROSIS, FDG-PET, POSITRON-EMISSION-TOMOGRAPHY, MRI, F-18 FDG, iomazenil, GLUCOSE PET, flumazenil, PARTIAL SEIZURES, FDG PET, TEMPORAL-LOBE EPILEPSY

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 150.60 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Goethals, Ingeborg, Christophe Van De Wiele, Paul Boon, and Rudi Dierckx. 2003. “Is Central Benzodiazepine Receptor Imaging Useful for the Identification of Epileptogenic Foci in Localization-related Epilepsies?” European Journal of Nuclear Medicine and Molecular Imaging 30 (2): 325–328.
APA
Goethals, Ingeborg, Van De Wiele, C., Boon, P., & Dierckx, R. (2003). Is central benzodiazepine receptor imaging useful for the identification of epileptogenic foci in localization-related epilepsies? EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 30(2), 325–328.
Vancouver
1.
Goethals I, Van De Wiele C, Boon P, Dierckx R. Is central benzodiazepine receptor imaging useful for the identification of epileptogenic foci in localization-related epilepsies? EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2003;30(2):325–8.
MLA
Goethals, Ingeborg, Christophe Van De Wiele, Paul Boon, et al. “Is Central Benzodiazepine Receptor Imaging Useful for the Identification of Epileptogenic Foci in Localization-related Epilepsies?” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 30.2 (2003): 325–328. Print.
@article{217894,
  abstract     = {In the presurgical evaluation of patients with partial epilepsies, the most extensively studied functional neuro-imaging modality to define the origin of seizure onset is fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET). Generally, this technique reveals a widespread zone of interictal glucose hypometabolism in the region of the epileptogenic focus. However, the technique may miss the epileptogenic region and FDG PET abnormalities may extend beyond the seizure onset zone. Consequently, for the precise identification of epileptogenic regions more specific imaging probes than FDG are warranted. This review considers the clinical utility of iomazenil (IMZ) SPET and flumazenil (FMZ) PET for the precise localization of epileptogenic foci in partial epilepsy syndromes.},
  author       = {Goethals, Ingeborg and Van De Wiele, Christophe and Boon, Paul and Dierckx, Rudi},
  issn         = {1619-7070},
  journal      = {EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING},
  keyword      = {epileptogenic foci,C-11 FLUMAZENIL PET,I-123 IOMAZENIL-SPECT,partial epilepsy syndromes,HIPPOCAMPAL SCLEROSIS,FDG-PET,POSITRON-EMISSION-TOMOGRAPHY,MRI,F-18 FDG,iomazenil,GLUCOSE PET,flumazenil,PARTIAL SEIZURES,FDG PET,TEMPORAL-LOBE EPILEPSY},
  language     = {eng},
  number       = {2},
  pages        = {325--328},
  title        = {Is central benzodiazepine receptor imaging useful for the identification of epileptogenic foci in localization-related epilepsies?},
  url          = {http://dx.doi.org/10.1007/s00259-002-1083-z},
  volume       = {30},
  year         = {2003},
}

Altmetric
View in Altmetric
Web of Science
Times cited: