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Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology

Bart Lambrecht UGent and Hamida Hammad UGent (2012) Annual Review of Immunology. In Annual Review of Immunology 30. p.243-270
abstract
Lung dendritic cells (DCs) bridge innate and adaptive immunity, and depending on context, they also induce a Th1, Th2, or Th17 response to optimally clear infectious threats. Conversely, lung DCs can also mount maladaptive Th2 immune responses to harmless allergens and, in this way, contribute to immunopathology. It is now clear that the various aspects of DC biology can be understood only if we take into account the functional specializations of different DC subsets that are present in the lung in homeostasis or are attracted to the lung as part of the inflammatory response to inhaled noxious stimuli. Lung DCs are heavily influenced by the nearby epithelial cells, and a model is emerging whereby direct communication between DCs and epithelial cells determines the outcome of the pulmonary immuneresponse. Here, we have approached DC biology from the perspective of viral infection and allergy to illustrate these emerging concepts.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
asthma, virus, dendritic cells, allergy, ALLERGIC AIRWAY INFLAMMATION, HOUSE-DUST MITE, CD8(+) T-CELL, THYMIC STROMAL LYMPHOPOIETIN, INFLUENZA-VIRUS INFECTION, AMBIENT PARTICULATE MATTER, HELPER TYPE-2 RESPONSE, BLOOD MONOCYTE SUBSETS, BRONCHIAL LYMPH-NODE, EPITHELIAL-CELLS
journal title
Annual Review of Immunology
Annu. Rev. Immunol.
series title
Annual Review of Immunology
volume
30
issue title
Annual review of immunology, vol. 30
pages
243 - 270
publisher
Annual Reviews
place of publication
Palo Alto, CA, USA
Web of Science type
Review; Book Chapter
Web of Science id
000304198100011
JCR category
IMMUNOLOGY
JCR impact factor
36.556 (2012)
JCR rank
1/134 (2012)
JCR quartile
1 (2012)
ISSN
0732-0582
ISBN
9780824330309
DOI
10.1146/annurev-immunol-020711-075021
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2153292
handle
http://hdl.handle.net/1854/LU-2153292
date created
2012-06-14 11:55:04
date last changed
2014-05-12 11:00:19
@article{2153292,
  abstract     = {Lung dendritic cells (DCs) bridge innate and adaptive immunity, and depending on context, they also induce a Th1, Th2, or Th17 response to optimally clear infectious threats. Conversely, lung DCs can also mount maladaptive Th2 immune responses to harmless allergens and, in this way, contribute to immunopathology. It is now clear that the various aspects of DC biology can be understood only if we take into account the functional specializations of different DC subsets that are present in the lung in homeostasis or are attracted to the lung as part of the inflammatory response to inhaled noxious stimuli. Lung DCs are heavily influenced by the nearby epithelial cells, and a model is emerging whereby direct communication between DCs and epithelial cells determines the outcome of the pulmonary immuneresponse. Here, we have approached DC biology from the perspective of viral infection and allergy to illustrate these emerging concepts.},
  author       = {Lambrecht, Bart and Hammad, Hamida},
  isbn         = {9780824330309},
  issn         = {0732-0582},
  journal      = {Annual Review of Immunology},
  keyword      = {asthma,virus,dendritic cells,allergy,ALLERGIC AIRWAY INFLAMMATION,HOUSE-DUST MITE,CD8(+) T-CELL,THYMIC STROMAL LYMPHOPOIETIN,INFLUENZA-VIRUS INFECTION,AMBIENT PARTICULATE MATTER,HELPER TYPE-2 RESPONSE,BLOOD MONOCYTE SUBSETS,BRONCHIAL LYMPH-NODE,EPITHELIAL-CELLS},
  language     = {eng},
  pages        = {243--270},
  publisher    = {Annual Reviews},
  title        = {Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology},
  url          = {http://dx.doi.org/10.1146/annurev-immunol-020711-075021},
  volume       = {30},
  year         = {2012},
}

Chicago
Lambrecht, Bart, and Hamida Hammad. 2012. “Lung Dendritic Cells in Respiratory Viral Infection and Asthma: From Protection to Immunopathology.” Annual Review of Immunology 30: 243–270.
APA
Lambrecht, B., & Hammad, H. (2012). Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology. Annual Review of Immunology, 30, 243–270.
Vancouver
1.
Lambrecht B, Hammad H. Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology. Annual Review of Immunology. Palo Alto, CA, USA: Annual Reviews; 2012;30:243–70.
MLA
Lambrecht, Bart, and Hamida Hammad. “Lung Dendritic Cells in Respiratory Viral Infection and Asthma: From Protection to Immunopathology.” Annual Review of Immunology 30 (2012): 243–270. Print.