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Gene expression profiling and molecular signaling of dental pulp cells in response to tricalcium silicate cements: a systematic review

Elanagai Rathinam UGent, Sivaprakash Rajasekharan UGent, Ravi Teja Chitturi, Luc Martens UGent and Peter De Coster UGent (2015) JOURNAL OF ENDODONTICS. 41(11). p.1805-1817
abstract
Introduction: Signaling molecules and responding dental pulp stem cells are the 2 main control keys of dentin regeneration/dentinogenesis. The aim of this study was to present a systematic review investigating the gene expression of various dental pulp cells in response to different variants of tricalcium silicate cements. Methods: A systematic search of the literature was performed by 2 independent reviewers followed by article selection and data extraction. Studies analyzing all sorts of dental pulp cells (DPCs) and any variant of tricalcium silicate cement either as the experimental or as the control group were included. Results: A total of 39 articles were included in the review. Among the included studies, Pro Root MTA (Dentsply, Tulsa Dental, OK) was the most commonly used tricalcium silicate cement variant. The extracellular signal regulated kinase/mitogen-activated protein kinase pathway was the most commonly activated pathway to be identified, and similarly, dentin sialophosphoprotein osteocalcin dentin matrix acidic phosphoprotein 1, alkaline phos. phatase, bone sialoprotein, osteopontin, type I collagen, and Runx2 were the most commonly expressed genes in that order of frequency. Conclusions: Biodentine (Septodont Ltd, Saint Maur des Fausses, France), Bioaggregate (Innovative Bioceramix, Vancouver, BC, Canada), and mineral trioxide aggregate stimulate the osteogenic/odontogenic capacity of DPCs by proliferation, angiogenesis, and biomineralization through the activation of the extracellular signal regulated kinase 1/2, nuclear factor E2 related factor 2, p38, c-Jun N-terminal kinase mitogen-activated protein kinase, p42/p44 mitogen-activated protein kinase, nuclear factor kappa B, and fibroblast growth factor receptor pathways. When DPCs are placed into direct contact with tricalcium silicate cements, they show higher levels of gene activation, which in turn could translate into more effective pulpal repair and faster and more predictable formation of reparative dentin.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
Dental pulp cells, gene expression, molecular signaling, stem cells, tricalcium silicate cements, MINERAL TRIOXIDE AGGREGATE, ACTIVATED PROTEIN-KINASE, ODONTO/OSTEOGENIC CAPACITY, ANGIOGENESIS-RELATED PROTEINS, STROMAL CELLS, ODONTOGENIC DIFFERENTIATION, STEM-CELLS, BONE-MARROW, ODONTOBLASTIC DIFFERENTIATION, IN-VITRO
journal title
JOURNAL OF ENDODONTICS
J. Endod.
volume
41
issue
11
pages
1805 - 1817
Web of Science type
Review
Web of Science id
000364437600005
JCR category
DENTISTRY, ORAL SURGERY & MEDICINE
JCR impact factor
2.904 (2015)
JCR rank
10/89 (2015)
JCR quartile
1 (2015)
ISSN
0099-2399
DOI
10.1016/j.joen.2015.07.015
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2152345
handle
http://hdl.handle.net/1854/LU-2152345
date created
2012-06-14 09:12:16
date last changed
2016-12-05 16:36:17
@article{2152345,
  abstract     = {Introduction: Signaling molecules and responding dental pulp stem cells are the 2 main control keys of dentin regeneration/dentinogenesis. The aim of this study was to present a systematic review investigating the gene expression of various dental pulp cells in response to different variants of tricalcium silicate cements.
Methods: A systematic search of the literature was performed by 2 independent reviewers followed by article selection and data extraction. Studies analyzing all sorts of dental pulp cells (DPCs) and any variant of tricalcium silicate cement either as the experimental or as the control group were included.
Results: A total of 39 articles were included in the review. Among the included studies, Pro Root MTA (Dentsply, Tulsa Dental, OK) was the most commonly used tricalcium silicate cement variant. The extracellular signal regulated kinase/mitogen-activated protein kinase pathway was the most commonly activated pathway to be identified, and similarly, dentin sialophosphoprotein osteocalcin dentin matrix acidic phosphoprotein 1, alkaline phos. phatase, bone sialoprotein, osteopontin, type I collagen, and Runx2 were the most commonly expressed genes in that order of frequency.
Conclusions: Biodentine (Septodont Ltd, Saint Maur des Fausses, France), Bioaggregate (Innovative Bioceramix, Vancouver, BC, Canada), and mineral trioxide aggregate stimulate the osteogenic/odontogenic capacity of DPCs by proliferation, angiogenesis, and biomineralization through the activation of the extracellular signal regulated kinase 1/2, nuclear factor E2 related factor 2, p38, c-Jun N-terminal kinase mitogen-activated protein kinase, p42/p44 mitogen-activated protein kinase, nuclear factor kappa B, and fibroblast growth factor receptor pathways. When DPCs are placed into direct contact with tricalcium silicate cements, they show higher levels of gene activation, which in turn could translate into more effective pulpal repair and faster and more predictable formation of reparative dentin.},
  author       = {Rathinam, Elanagai and Rajasekharan, Sivaprakash and Chitturi, Ravi Teja and Martens, Luc and De Coster, Peter},
  issn         = {0099-2399},
  journal      = {JOURNAL OF ENDODONTICS},
  keyword      = {Dental pulp cells,gene expression,molecular signaling,stem cells,tricalcium silicate cements,MINERAL TRIOXIDE AGGREGATE,ACTIVATED PROTEIN-KINASE,ODONTO/OSTEOGENIC CAPACITY,ANGIOGENESIS-RELATED PROTEINS,STROMAL CELLS,ODONTOGENIC DIFFERENTIATION,STEM-CELLS,BONE-MARROW,ODONTOBLASTIC DIFFERENTIATION,IN-VITRO},
  language     = {eng},
  number       = {11},
  pages        = {1805--1817},
  title        = {Gene expression profiling and molecular signaling of dental pulp cells in response to tricalcium silicate cements: a systematic review},
  url          = {http://dx.doi.org/10.1016/j.joen.2015.07.015},
  volume       = {41},
  year         = {2015},
}

Chicago
Rathinam, Elanagai, Sivaprakash Rajasekharan, Ravi Teja Chitturi, Luc Martens, and Peter De Coster. 2015. “Gene Expression Profiling and Molecular Signaling of Dental Pulp Cells in Response to Tricalcium Silicate Cements: a Systematic Review.” Journal of Endodontics 41 (11): 1805–1817.
APA
Rathinam, E., Rajasekharan, S., Chitturi, R. T., Martens, L., & De Coster, P. (2015). Gene expression profiling and molecular signaling of dental pulp cells in response to tricalcium silicate cements: a systematic review. JOURNAL OF ENDODONTICS, 41(11), 1805–1817.
Vancouver
1.
Rathinam E, Rajasekharan S, Chitturi RT, Martens L, De Coster P. Gene expression profiling and molecular signaling of dental pulp cells in response to tricalcium silicate cements: a systematic review. JOURNAL OF ENDODONTICS. 2015;41(11):1805–17.
MLA
Rathinam, Elanagai, Sivaprakash Rajasekharan, Ravi Teja Chitturi, et al. “Gene Expression Profiling and Molecular Signaling of Dental Pulp Cells in Response to Tricalcium Silicate Cements: a Systematic Review.” JOURNAL OF ENDODONTICS 41.11 (2015): 1805–1817. Print.