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Prior knowledge of HPV status improves detection of CIN2+ by cytology screening

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Abstract
OBJECTIVE: The objective of the study was to investigate whether knowledge of human papillomavirus (HPV) deoxyribonucleic acid test results increases sensitivity of guided cytology screening for the detection of cervical intraepithelial neoplasia (CIN)-2 or higher-grade cervical lesions. STUDY DESIGN: This was a prospective colposcopy-controlled study of 2905 BD SurePath samples to identify cases with CIN2+ within a 24 month follow-up period. Sensitivity and specificity to detect CIN2+ was evaluated, comparing guided cytology screening with and without prior knowledge of HPV status. RESULTS: Prior knowledge of HPV status resulted in significantly higher detection rate of CIN2+ compared with screening blinded to HPV status (P = .005) with limited loss of specificity (P = .026). Gain in sensitivity is higher in older women (43.8%, P = .008) vs in younger women (10.2%, P = .317), whereas loss of specificity is more pronounced in younger women (P < .001) vs older women (P = .729). CONCLUSION: Guided cytological screening performed with prior knowledge of HPV status results in an improved detection of CIN2 or higher-grade lesions.
Keywords
human papillomavirus, cervical cytology, cervical cancer, SYSTEM, CERVICAL-CANCER, human papillomavirus genotypes, real-time polymerase chain reaction

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Chicago
Benoy, Ina H, Davy Vanden Broeck, MAYA RUYMBEKE, Shaira Sahebali, Marc Arbyn, Johannes J Bogers, Marleen Temmerman, and Christophe E Depuydt. 2011. “Prior Knowledge of HPV Status Improves Detection of CIN2+ by Cytology Screening.” American Journal of Obstetrics and Gynecology 205 (6).
APA
Benoy, I. H., Vanden Broeck, D., RUYMBEKE, M., Sahebali, S., Arbyn, M., Bogers, J. J., Temmerman, M., et al. (2011). Prior knowledge of HPV status improves detection of CIN2+ by cytology screening. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 205(6).
Vancouver
1.
Benoy IH, Vanden Broeck D, RUYMBEKE M, Sahebali S, Arbyn M, Bogers JJ, et al. Prior knowledge of HPV status improves detection of CIN2+ by cytology screening. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 2011;205(6).
MLA
Benoy, Ina H, Davy Vanden Broeck, MAYA RUYMBEKE, et al. “Prior Knowledge of HPV Status Improves Detection of CIN2+ by Cytology Screening.” AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 205.6 (2011): n. pag. Print.
@article{2147921,
  abstract     = {OBJECTIVE: The objective of the study was to investigate whether knowledge of human papillomavirus (HPV) deoxyribonucleic acid test results increases sensitivity of guided cytology screening for the detection of cervical intraepithelial neoplasia (CIN)-2 or higher-grade cervical lesions. 
STUDY DESIGN: This was a prospective colposcopy-controlled study of 2905 BD SurePath samples to identify cases with CIN2+ within a 24 month follow-up period. Sensitivity and specificity to detect CIN2+ was evaluated, comparing guided cytology screening with and without prior knowledge of HPV status. 
RESULTS: Prior knowledge of HPV status resulted in significantly higher detection rate of CIN2+ compared with screening blinded to HPV status (P = .005) with limited loss of specificity (P = .026). Gain in sensitivity is higher in older women (43.8\%, P = .008) vs in younger women (10.2\%, P = .317), whereas loss of specificity is more pronounced in younger women (P {\textlangle} .001) vs older women (P = .729). 
CONCLUSION: Guided cytological screening performed with prior knowledge of HPV status results in an improved detection of CIN2 or higher-grade lesions.},
  articleno    = {569.e1},
  author       = {Benoy, Ina H and Vanden Broeck, Davy and RUYMBEKE, MAYA and Sahebali, Shaira and Arbyn, Marc and Bogers, Johannes J and Temmerman, Marleen and Depuydt, Christophe E},
  issn         = {0002-9378},
  journal      = {AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY},
  keyword      = {human papillomavirus,cervical cytology,cervical cancer,SYSTEM,CERVICAL-CANCER,human papillomavirus genotypes,real-time polymerase chain reaction},
  language     = {eng},
  number       = {6},
  pages        = {7},
  title        = {Prior knowledge of HPV status improves detection of CIN2+ by cytology screening},
  url          = {http://dx.doi.org/10.1016/j.ajog.2011.06.101},
  volume       = {205},
  year         = {2011},
}

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