Ghent University Academic Bibliography

Advanced

Prior knowledge of HPV status improves detection of CIN2+ by cytology screening

Ina H Benoy, Davy Vanden Broeck UGent, MAYA RUYMBEKE UGent, Shaira Sahebali, Marc Arbyn, Johannes J Bogers, Marleen Temmerman UGent and Christophe E Depuydt (2011) AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 205(6).
abstract
OBJECTIVE: The objective of the study was to investigate whether knowledge of human papillomavirus (HPV) deoxyribonucleic acid test results increases sensitivity of guided cytology screening for the detection of cervical intraepithelial neoplasia (CIN)-2 or higher-grade cervical lesions. STUDY DESIGN: This was a prospective colposcopy-controlled study of 2905 BD SurePath samples to identify cases with CIN2+ within a 24 month follow-up period. Sensitivity and specificity to detect CIN2+ was evaluated, comparing guided cytology screening with and without prior knowledge of HPV status. RESULTS: Prior knowledge of HPV status resulted in significantly higher detection rate of CIN2+ compared with screening blinded to HPV status (P = .005) with limited loss of specificity (P = .026). Gain in sensitivity is higher in older women (43.8%, P = .008) vs in younger women (10.2%, P = .317), whereas loss of specificity is more pronounced in younger women (P < .001) vs older women (P = .729). CONCLUSION: Guided cytological screening performed with prior knowledge of HPV status results in an improved detection of CIN2 or higher-grade lesions.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
human papillomavirus, cervical cytology, cervical cancer, SYSTEM, CERVICAL-CANCER, human papillomavirus genotypes, real-time polymerase chain reaction
journal title
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Am. J. Obstet. Gynecol.
volume
205
issue
6
article number
569.e1
pages
7 pages
Web of Science type
Article
Web of Science id
000297329200033
JCR category
OBSTETRICS & GYNECOLOGY
JCR impact factor
3.468 (2011)
JCR rank
9/78 (2011)
JCR quartile
1 (2011)
ISSN
0002-9378
DOI
10.1016/j.ajog.2011.06.101
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2147921
handle
http://hdl.handle.net/1854/LU-2147921
date created
2012-06-13 14:27:42
date last changed
2016-12-21 15:41:53
@article{2147921,
  abstract     = {OBJECTIVE: The objective of the study was to investigate whether knowledge of human papillomavirus (HPV) deoxyribonucleic acid test results increases sensitivity of guided cytology screening for the detection of cervical intraepithelial neoplasia (CIN)-2 or higher-grade cervical lesions. 
STUDY DESIGN: This was a prospective colposcopy-controlled study of 2905 BD SurePath samples to identify cases with CIN2+ within a 24 month follow-up period. Sensitivity and specificity to detect CIN2+ was evaluated, comparing guided cytology screening with and without prior knowledge of HPV status. 
RESULTS: Prior knowledge of HPV status resulted in significantly higher detection rate of CIN2+ compared with screening blinded to HPV status (P = .005) with limited loss of specificity (P = .026). Gain in sensitivity is higher in older women (43.8\%, P = .008) vs in younger women (10.2\%, P = .317), whereas loss of specificity is more pronounced in younger women (P {\textlangle} .001) vs older women (P = .729). 
CONCLUSION: Guided cytological screening performed with prior knowledge of HPV status results in an improved detection of CIN2 or higher-grade lesions.},
  articleno    = {569.e1},
  author       = {Benoy, Ina H and Vanden Broeck, Davy and RUYMBEKE, MAYA and Sahebali, Shaira and Arbyn, Marc and Bogers, Johannes J and Temmerman, Marleen and Depuydt, Christophe E},
  issn         = {0002-9378},
  journal      = {AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY},
  keyword      = {human papillomavirus,cervical cytology,cervical cancer,SYSTEM,CERVICAL-CANCER,human papillomavirus genotypes,real-time polymerase chain reaction},
  language     = {eng},
  number       = {6},
  pages        = {7},
  title        = {Prior knowledge of HPV status improves detection of CIN2+ by cytology screening},
  url          = {http://dx.doi.org/10.1016/j.ajog.2011.06.101},
  volume       = {205},
  year         = {2011},
}

Chicago
Benoy, Ina H, Davy Vanden Broeck, MAYA RUYMBEKE, Shaira Sahebali, Marc Arbyn, Johannes J Bogers, Marleen Temmerman, and Christophe E Depuydt. 2011. “Prior Knowledge of HPV Status Improves Detection of CIN2+ by Cytology Screening.” American Journal of Obstetrics and Gynecology 205 (6).
APA
Benoy, I. H., Vanden Broeck, D., RUYMBEKE, M., Sahebali, S., Arbyn, M., Bogers, J. J., Temmerman, M., et al. (2011). Prior knowledge of HPV status improves detection of CIN2+ by cytology screening. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 205(6).
Vancouver
1.
Benoy IH, Vanden Broeck D, RUYMBEKE M, Sahebali S, Arbyn M, Bogers JJ, et al. Prior knowledge of HPV status improves detection of CIN2+ by cytology screening. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 2011;205(6).
MLA
Benoy, Ina H, Davy Vanden Broeck, MAYA RUYMBEKE, et al. “Prior Knowledge of HPV Status Improves Detection of CIN2+ by Cytology Screening.” AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 205.6 (2011): n. pag. Print.