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DRL1, a homolog of the yeast TOT4/KT112 protein, has a function in meristem activity and organ growth in plants

Hilde Nelissen UGent, Jonathan H Clarke, Marc De Block, Sabine De Block, Rudy Vanderhaeghen UGent, Raymond E Zielinski, Tristan Dyer, Sofie Lust, Dirk Inzé UGent and Maria Van Lijsebettens UGent (2003) PLANT CELL. 15(3). p.639-654
abstract
The DEFORMED ROOTS AND LEAVES1 (DRL1) gene is single copy in the Arabidopsis genome, and based on overall amino acid similarity and conservation of functional domains, the DRL1 protein is homologous with yeast TOT4/KTl12. TOT4/ KTl12 associates with Elongator, a multisubunit complex that binds the RNA polymerase II transcription elongation complex. Recessive mutations at the DRL1 locus caused defective organ formation indicative of disorganized shoot, inflorescence, flower, and root meristems. DRL1 is a putative ATP/GTP binding protein; in addition, calmodulin binding activity was demonstrated in vitro for the C terminus of the DRL1 protein. Phenotypic and genetic data position DRL1 relative to regulatory loci for leaf development, in which it acts early. We identified Arabidopsis homologs for the six Elongator components and hypothesize that DRL1 regulates transcription elongation through a putative plant Elongator. Upregulation of the ANGUSTIFOLIA transcript in the strong dri1-2 allele supports this model.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
POLYMERASE-II HOLOENZYME, KLUYVEROMYCES-LACTIS ZYMOCIN, SACCHAROMYCES-CEREVISIAE GENES, CALMODULIN-BINDING PROTEINS, THALIANA L HEYNH, STEM-CELL FATE, ARABIDOPSIS-THALIANA, BETA-GLUCURONIDASE, SHOOT MERISTEM, AGROBACTERIUM-TUMEFACIENS
journal title
PLANT CELL
Plant Cell
volume
15
issue
3
pages
639 - 654
Web of Science type
Article
Web of Science id
000185078000007
JCR category
PLANT SCIENCES
JCR impact factor
10.679 (2003)
JCR rank
3/136 (2003)
JCR quartile
1 (2003)
ISSN
1040-4651
DOI
10.1105/tpc.007062
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
214698
handle
http://hdl.handle.net/1854/LU-214698
date created
2004-05-05 18:43:00
date last changed
2016-12-19 15:39:03
@article{214698,
  abstract     = {The DEFORMED ROOTS AND LEAVES1 (DRL1) gene is single copy in the Arabidopsis genome, and based on overall amino acid similarity and conservation of functional domains, the DRL1 protein is homologous with yeast TOT4/KTl12. TOT4/ KTl12 associates with Elongator, a multisubunit complex that binds the RNA polymerase II transcription elongation complex. Recessive mutations at the DRL1 locus caused defective organ formation indicative of disorganized shoot, inflorescence, flower, and root meristems. DRL1 is a putative ATP/GTP binding protein; in addition, calmodulin binding activity was demonstrated in vitro for the C terminus of the DRL1 protein. Phenotypic and genetic data position DRL1 relative to regulatory loci for leaf development, in which it acts early. We identified Arabidopsis homologs for the six Elongator components and hypothesize that DRL1 regulates transcription elongation through a putative plant Elongator. Upregulation of the ANGUSTIFOLIA transcript in the strong dri1-2 allele supports this model.},
  author       = {Nelissen, Hilde and Clarke, Jonathan H and De Block, Marc and De Block, Sabine and Vanderhaeghen, Rudy and Zielinski, Raymond E and Dyer, Tristan and Lust, Sofie and Inz{\'e}, Dirk and Van Lijsebettens, Maria},
  issn         = {1040-4651},
  journal      = {PLANT CELL},
  keyword      = {POLYMERASE-II HOLOENZYME,KLUYVEROMYCES-LACTIS ZYMOCIN,SACCHAROMYCES-CEREVISIAE GENES,CALMODULIN-BINDING PROTEINS,THALIANA L HEYNH,STEM-CELL FATE,ARABIDOPSIS-THALIANA,BETA-GLUCURONIDASE,SHOOT MERISTEM,AGROBACTERIUM-TUMEFACIENS},
  language     = {eng},
  number       = {3},
  pages        = {639--654},
  title        = {DRL1, a homolog of the yeast TOT4/KT112 protein, has a function in meristem activity and organ growth in plants},
  url          = {http://dx.doi.org/10.1105/tpc.007062},
  volume       = {15},
  year         = {2003},
}

Chicago
Nelissen, Hilde, Jonathan H Clarke, Marc De Block, Sabine De Block, Rudy Vanderhaeghen, Raymond E Zielinski, Tristan Dyer, Sofie Lust, Dirk Inzé, and Maria Van Lijsebettens. 2003. “DRL1, a Homolog of the Yeast TOT4/KT112 Protein, Has a Function in Meristem Activity and Organ Growth in Plants.” Plant Cell 15 (3): 639–654.
APA
Nelissen, H., Clarke, J. H., De Block, M., De Block, S., Vanderhaeghen, R., Zielinski, R. E., Dyer, T., et al. (2003). DRL1, a homolog of the yeast TOT4/KT112 protein, has a function in meristem activity and organ growth in plants. PLANT CELL, 15(3), 639–654.
Vancouver
1.
Nelissen H, Clarke JH, De Block M, De Block S, Vanderhaeghen R, Zielinski RE, et al. DRL1, a homolog of the yeast TOT4/KT112 protein, has a function in meristem activity and organ growth in plants. PLANT CELL. 2003;15(3):639–54.
MLA
Nelissen, Hilde, Jonathan H Clarke, Marc De Block, et al. “DRL1, a Homolog of the Yeast TOT4/KT112 Protein, Has a Function in Meristem Activity and Organ Growth in Plants.” PLANT CELL 15.3 (2003): 639–654. Print.