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All-trans retinoic acid is increased in the acute phase-related hyporetinemia during Escherichia coli mastitis

V VAN MERRIS, Evelyne Meyer UGent, Luc Duchateau UGent, J BLUM and Christian Burvenich UGent (2004) JOURNAL OF DAIRY SCIENCE. 87(4). p.980-987
abstract
Blood vitamin A profiles, including concentrations of retinol and its active metabolite retinoic acid, were assessed during the peripartum period and during experimentally induced Escherichia coli mastitis in heifers. Serum retinol decreased in all animals in the immediate postpartum period and normalized within 1 wk after parturition. No significant changes were detectable in the concentrations of retinoic acid isomers during puerperium. Following intramammary E. coli infusion, all cows showed moderate symptoms of systemic disease besides the local signs of inflammation. The presence of a systemic acute-phase reaction was documented by fever, increase in serum amyloid A, and decrease in serum albumin. Retinol concentration in serum also decreased spectacularly during coliform mastitis, and the decline was clearly related to the timing of the acute-phase response. Moreover, a significant increase of all-trans retinoic acid, mirrored by a lowering of 13-cis retinoic acid, was detected during the same time period. The 9-cis isomer of retinoic acid was present in all samples, but it remained below the quantification limit. Results confirmed the decrease in serum retinol during the peripartum period of dairy cows. Furthermore, the study established that profound changes in vitamin A metabolism occur during the acute-phase reaction of coliform mastitis in heifers. The bovine infection model reproduced the acute phase-related hyporetinemia, as previously observed in humans and rats. In addition, all-trans retinoic acid was found to be the most abundant circulating acid isomer during mastitis, providing an indication for a possible key role of all-trans retinoic acid in the modulation of the immune response.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
EARLY LACTATION, PERIPARTURIENT PERIOD, MILK FEVER, INFECTION, PLASMA, Escherichia coli mastitis, retinoic acid, peripartum period, BETA-CAROTENE, VITAMIN-A, acute-phase response, NECROSIS-FACTOR-ALPHA, SERUM RETINOL, DAIRY-COWS
journal title
JOURNAL OF DAIRY SCIENCE
J. Dairy Sci.
volume
87
issue
4
pages
980-987 pages
publisher
AMER DAIRY SCIENCE ASSOC
Web of Science type
Article
Web of Science id
000220786300023
JCR category
AGRICULTURE, DAIRY & ANIMAL SCIENCE
JCR impact factor
2.134 (2004)
JCR rank
3/41 (2004)
JCR quartile
1 (2004)
ISSN
0022-0302
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
213945
handle
http://hdl.handle.net/1854/LU-213945
date created
2004-05-03 08:35:00
date last changed
2016-12-19 15:44:50
@article{213945,
  abstract     = {Blood vitamin A profiles, including concentrations of retinol and its active metabolite retinoic acid, were assessed during the peripartum period and during experimentally induced Escherichia coli mastitis in heifers. Serum retinol decreased in all animals in the immediate postpartum period and normalized within 1 wk after parturition. No significant changes were detectable in the concentrations of retinoic acid isomers during puerperium. Following intramammary E. coli infusion, all cows showed moderate symptoms of systemic disease besides the local signs of inflammation. The presence of a systemic acute-phase reaction was documented by fever, increase in serum amyloid A, and decrease in serum albumin. Retinol concentration in serum also decreased spectacularly during coliform mastitis, and the decline was clearly related to the timing of the acute-phase response. Moreover, a significant increase of all-trans retinoic acid, mirrored by a lowering of 13-cis retinoic acid, was detected during the same time period. The 9-cis isomer of retinoic acid was present in all samples, but it remained below the quantification limit.
Results confirmed the decrease in serum retinol during the peripartum period of dairy cows. Furthermore, the study established that profound changes in vitamin A metabolism occur during the acute-phase reaction of coliform mastitis in heifers. The bovine infection model reproduced the acute phase-related hyporetinemia, as previously observed in humans and rats. In addition, all-trans retinoic acid was found to be the most abundant circulating acid isomer during mastitis, providing an indication for a possible key role of all-trans retinoic acid in the modulation of the immune response.},
  author       = {VAN MERRIS, V and Meyer, Evelyne and Duchateau, Luc and BLUM, J and Burvenich, Christian},
  issn         = {0022-0302},
  journal      = {JOURNAL OF DAIRY SCIENCE},
  keyword      = {EARLY LACTATION,PERIPARTURIENT PERIOD,MILK FEVER,INFECTION,PLASMA,Escherichia coli mastitis,retinoic acid,peripartum period,BETA-CAROTENE,VITAMIN-A,acute-phase response,NECROSIS-FACTOR-ALPHA,SERUM RETINOL,DAIRY-COWS},
  language     = {eng},
  number       = {4},
  pages        = {980--987},
  publisher    = {AMER DAIRY SCIENCE ASSOC},
  title        = {All-trans retinoic acid is increased in the acute phase-related hyporetinemia during Escherichia coli mastitis},
  volume       = {87},
  year         = {2004},
}

Chicago
VAN MERRIS, V, Evelyne Meyer, Luc Duchateau, J BLUM, and Christian Burvenich. 2004. “All-trans Retinoic Acid Is Increased in the Acute Phase-related Hyporetinemia During Escherichia Coli Mastitis.” Journal of Dairy Science 87 (4): 980–987.
APA
VAN MERRIS, V., Meyer, E., Duchateau, L., BLUM, J., & Burvenich, C. (2004). All-trans retinoic acid is increased in the acute phase-related hyporetinemia during Escherichia coli mastitis. JOURNAL OF DAIRY SCIENCE, 87(4), 980–987.
Vancouver
1.
VAN MERRIS V, Meyer E, Duchateau L, BLUM J, Burvenich C. All-trans retinoic acid is increased in the acute phase-related hyporetinemia during Escherichia coli mastitis. JOURNAL OF DAIRY SCIENCE. AMER DAIRY SCIENCE ASSOC; 2004;87(4):980–7.
MLA
VAN MERRIS, V, Evelyne Meyer, Luc Duchateau, et al. “All-trans Retinoic Acid Is Increased in the Acute Phase-related Hyporetinemia During Escherichia Coli Mastitis.” JOURNAL OF DAIRY SCIENCE 87.4 (2004): 980–987. Print.