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Sunlight is an important determinant of vitamin D serum concentrations in cystic fibrosis

Eddy Robberecht UGent, Sara Vandewalle UGent, Charline Wehlou UGent, Jean Kaufman UGent and Jean De Schepper UGent (2011) EUROPEAN JOURNAL OF CLINICAL NUTRITION. 65(5). p.574-579
abstract
Background/Objectives: The increase of bone disease in adult cystic fibrosis (CF) patients is partly attributed to inadequate serum concentrations of 25-OH cholecalciferol (25 (OH) D) blamed on fat malabsorption. Based on physiological, clinical and biochemical observations this pathogenesis is debatable. The objective was to ascertain the relative importance of different 25 (OH) D sources. Subjects/Methods: Over 4 consecutive years, 474 annual 25 (OH) D serum concentrations from 141 CF patients of all ages were compared with values of healthy peers and weighed against annual ultraviolet B (UVB) exposure. Results: Ranked per month, 25 (OH) D concentrations depicted a curve strikingly parallel to the amount of UVB exposure in the preceding months. A significant difference exists between 25 (OH) D concentrations in the 'Months with high UVB exposure' (May-October) and the 'Months with low UVB exposure' (November-April) but not with healthy controls in the same period. Conclusions: 25 (OH) D concentrations clearly respond to the amount of sunshine in preceding months. They are not clearly influenced by daily oral supplements of 800 IU of cholecalciferol. Sun exposure should be encouraged, and the recommended dosage of oral supplements increased.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
25-OH cholecalciferol serum concentrations, cystic fibrosis, sunshine, oral vitamin D supplements, children and adolescents, adults, BONE-MINERAL DENSITY, D DEFICIENCY, D INSUFFICIENCY, ELDERLY-WOMEN, UV-LIGHT, CHILDREN, ADULTS, ERGOCALCIFEROL, ADOLESCENTS, CHOLECALCIFEROL
journal title
EUROPEAN JOURNAL OF CLINICAL NUTRITION
Eur. J. Clin. Nutr.
volume
65
issue
5
pages
574 - 579
Web of Science type
Article
Web of Science id
000290249200003
JCR category
NUTRITION & DIETETICS
JCR impact factor
2.462 (2011)
JCR rank
30/71 (2011)
JCR quartile
2 (2011)
ISSN
0954-3007
DOI
10.1038/ejcn.2010.280
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2139372
handle
http://hdl.handle.net/1854/LU-2139372
date created
2012-06-11 15:01:22
date last changed
2012-06-19 09:34:19
@article{2139372,
  abstract     = {Background/Objectives: The increase of bone disease in adult cystic fibrosis (CF) patients is partly attributed to inadequate serum concentrations of 25-OH cholecalciferol (25 (OH) D) blamed on fat malabsorption. Based on physiological, clinical and biochemical observations this pathogenesis is debatable. The objective was to ascertain the relative importance of different 25 (OH) D sources. 
Subjects/Methods: Over 4 consecutive years, 474 annual 25 (OH) D serum concentrations from 141 CF patients of all ages were compared with values of healthy peers and weighed against annual ultraviolet B (UVB) exposure. 
Results: Ranked per month, 25 (OH) D concentrations depicted a curve strikingly parallel to the amount of UVB exposure in the preceding months. A significant difference exists between 25 (OH) D concentrations in the 'Months with high UVB exposure' (May-October) and the 'Months with low UVB exposure' (November-April) but not with healthy controls in the same period. 
Conclusions: 25 (OH) D concentrations clearly respond to the amount of sunshine in preceding months. They are not clearly influenced by daily oral supplements of 800 IU of cholecalciferol. Sun exposure should be encouraged, and the recommended dosage of oral supplements increased.},
  author       = {Robberecht, Eddy and Vandewalle, Sara and Wehlou, Charline and Kaufman, Jean and De Schepper, Jean},
  issn         = {0954-3007},
  journal      = {EUROPEAN JOURNAL OF CLINICAL NUTRITION},
  keyword      = {25-OH cholecalciferol serum concentrations,cystic fibrosis,sunshine,oral vitamin D supplements,children and adolescents,adults,BONE-MINERAL DENSITY,D DEFICIENCY,D INSUFFICIENCY,ELDERLY-WOMEN,UV-LIGHT,CHILDREN,ADULTS,ERGOCALCIFEROL,ADOLESCENTS,CHOLECALCIFEROL},
  language     = {eng},
  number       = {5},
  pages        = {574--579},
  title        = {Sunlight is an important determinant of vitamin D serum concentrations in cystic fibrosis},
  url          = {http://dx.doi.org/10.1038/ejcn.2010.280},
  volume       = {65},
  year         = {2011},
}

Chicago
Robberecht, Eddy, Sara Vandewalle, Charline Wehlou, Jean Kaufman, and Jean De Schepper. 2011. “Sunlight Is an Important Determinant of Vitamin D Serum Concentrations in Cystic Fibrosis.” European Journal of Clinical Nutrition 65 (5): 574–579.
APA
Robberecht, E., Vandewalle, S., Wehlou, C., Kaufman, J., & De Schepper, J. (2011). Sunlight is an important determinant of vitamin D serum concentrations in cystic fibrosis. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 65(5), 574–579.
Vancouver
1.
Robberecht E, Vandewalle S, Wehlou C, Kaufman J, De Schepper J. Sunlight is an important determinant of vitamin D serum concentrations in cystic fibrosis. EUROPEAN JOURNAL OF CLINICAL NUTRITION. 2011;65(5):574–9.
MLA
Robberecht, Eddy, Sara Vandewalle, Charline Wehlou, et al. “Sunlight Is an Important Determinant of Vitamin D Serum Concentrations in Cystic Fibrosis.” EUROPEAN JOURNAL OF CLINICAL NUTRITION 65.5 (2011): 574–579. Print.