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Design of a realistic PET-CT-MRI phantom

Vincent Keereman UGent, Pieter Mollet UGent, Yves Fierens, Samuel Espana Palomares UGent and Stefaan Vandenberghe UGent (2011) IEEE Nuclear Science Symposium Conference Record. p.3173-3177
abstract
The validation of the PET image quality of new PET-MRI systems should be done against the image quality of currently available PET-CT systems. This includes the validation of new attenuation correction methods. Such validation studies should preferentially be done using a phantom. There are currently no phantoms that have a realistic appearance on PET, CT and MRI. In this work we present the design and evaluation of such a phantom. The four most important tissue types for attenuation correction are air, lung, soft tissue and bone. An attenuation correction phantom should therefore contain these four tissue types. As it is difficult to mimic bone and lung on all three modalities using a synthetic material, we propose the use of biological material obtained from cadavers. For the lung section a lobe of a pig lung was used. It was excised and inflated using a ventilator. For the bone section the middle section of a bovine femur was used. Both parts were fixed inside a PMMA cylinder with radius 10 cm. The phantom was filled with 18F-FDG and two hot spheres and one cold sphere were added. First a PET scan was acquired on a PET-CT system. Subsequently, a transmission measurement and a CT acquisition were done on the same system. Afterwards, the phantom was moved to the MRI facility and a UTE-MRI was acquired. Average CT values and MRI R 2 values in bone and lung were calculated to evaluate the realistic appearance of the phantom on both modalities. The PET data was reconstructed with CT-based, transmission-based and MRI-based attenuation correction. The activity in the hot and cold spheres in the images reconstructed using transmission-based and MRI-based attenuation correction was compared to the reconstructed activity using CT-based attenuation correction. The average CT values in lung and bone were -630 HU and 1300 HU respectively. The average R 2 values were 0.7 ms -1 and 1.05 ms -1 respectively. These values are comparable to the values observed in clinical data sets. Transmission-based and MRI-based attenuation correction yielded an average difference with CT- based attenuation correction in the hot spots of -22 % and -8 %. In the cold spot the average differences were +3 % and -8 %. The construction of a PET-CT-MRI phantom was described. The phantom has a realistic appearance on all three modalities. It was used to evaluate two attenuation correction methods for PET-MRI scanners.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
MRI, attenuation correction, CT, PET-MRI, PET
in
IEEE Nuclear Science Symposium Conference Record
issue title
2011 IEEE Nuclear science symposium and medical imaging conference (NSS/MIC)
pages
3173 - 3177
publisher
IEEE
place of publication
Piscataway, NJ, USA
conference name
2011 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC 2011)
conference location
Valencia, Spain
conference start
2011-10-23
conference end
2011-10-29
Web of Science type
Proceedings Paper
Web of Science id
000304755603091
ISSN
1082-3654
ISBN
9781467301183
DOI
10.1109/NSSMIC.2011.6153651
language
English
UGent publication?
yes
classification
P1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2139343
handle
http://hdl.handle.net/1854/LU-2139343
date created
2012-06-11 14:53:50
date last changed
2013-02-19 15:30:12
@inproceedings{2139343,
  abstract     = {The validation of the PET image quality of new PET-MRI systems should be done against the image quality of currently available PET-CT systems. This includes the validation of new attenuation correction methods. Such validation studies should preferentially be done using a phantom. There are currently no phantoms that have a realistic appearance on PET, CT and MRI. In this work we present the design and evaluation of such a phantom. The four most important tissue types for attenuation correction are air, lung, soft tissue and bone. An attenuation correction phantom should therefore contain these four tissue types. As it is difficult to mimic bone and lung on all three modalities using a synthetic material, we propose the use of biological material obtained from cadavers. For the lung section a lobe of a pig lung was used. It was excised and inflated using a ventilator. For the bone section the middle section of a bovine femur was used. Both parts were fixed inside a PMMA cylinder with radius 10 cm. The phantom was filled with 18F-FDG and two hot spheres and one cold sphere were added. First a PET scan was acquired on a PET-CT system. Subsequently, a transmission measurement and a CT acquisition were done on the same system. Afterwards, the phantom was moved to the MRI facility and a UTE-MRI was acquired. Average CT values and MRI R 2 values in bone and lung were calculated to evaluate the realistic appearance of the phantom on both modalities. The PET data was reconstructed with CT-based, transmission-based and MRI-based attenuation correction. The activity in the hot and cold spheres in the images reconstructed using transmission-based and MRI-based attenuation correction was compared to the reconstructed activity using CT-based attenuation correction. The average CT values in lung and bone were -630 HU and 1300 HU respectively. The average R 2 values were 0.7 ms -1 and 1.05 ms -1 respectively. These values are comparable to the values observed in clinical data sets. Transmission-based and MRI-based attenuation correction yielded an average difference with CT- based attenuation correction in the hot spots of -22 \% and -8 \%. In the cold spot the average differences were +3 \% and -8 \%. The construction of a PET-CT-MRI phantom was described. The phantom has a realistic appearance on all three modalities. It was used to evaluate two attenuation correction methods for PET-MRI scanners.},
  author       = {Keereman, Vincent and Mollet, Pieter and Fierens, Yves  and Espana Palomares, Samuel and Vandenberghe, Stefaan},
  booktitle    = {IEEE Nuclear Science Symposium Conference Record},
  isbn         = {9781467301183},
  issn         = {1082-3654},
  keyword      = {MRI,attenuation correction,CT,PET-MRI,PET},
  language     = {eng},
  location     = {Valencia, Spain},
  pages        = {3173--3177},
  publisher    = {IEEE},
  title        = {Design of a realistic PET-CT-MRI phantom},
  url          = {http://dx.doi.org/10.1109/NSSMIC.2011.6153651},
  year         = {2011},
}

Chicago
Keereman, Vincent, Pieter Mollet, Yves Fierens, Samuel Espana Palomares, and Stefaan Vandenberghe. 2011. “Design of a Realistic PET-CT-MRI Phantom.” In IEEE Nuclear Science Symposium Conference Record, 3173–3177. Piscataway, NJ, USA: IEEE.
APA
Keereman, V., Mollet, P., Fierens, Y., Espana Palomares, S., & Vandenberghe, S. (2011). Design of a realistic PET-CT-MRI phantom. IEEE Nuclear Science Symposium Conference Record (pp. 3173–3177). Presented at the 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC 2011), Piscataway, NJ, USA: IEEE.
Vancouver
1.
Keereman V, Mollet P, Fierens Y, Espana Palomares S, Vandenberghe S. Design of a realistic PET-CT-MRI phantom. IEEE Nuclear Science Symposium Conference Record. Piscataway, NJ, USA: IEEE; 2011. p. 3173–7.
MLA
Keereman, Vincent, Pieter Mollet, Yves Fierens, et al. “Design of a Realistic PET-CT-MRI Phantom.” IEEE Nuclear Science Symposium Conference Record. Piscataway, NJ, USA: IEEE, 2011. 3173–3177. Print.