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Adipose tissue as regulator of vascular tone

Charlotte Boydens UGent, Nele Maenhaut UGent, Bart Pauwels, Kelly Decaluwé and Johan Van de Voorde UGent (2012) CURRENT HYPERTENSION REPORTS. 14(3). p.270-278
abstract
Adipokines secreted by visceral, subcutaneous, and perivascular adipocytes are involved in the regulation of vascular tone by acting as circulatory hormones (leptin, adiponectin, omentin, visfatin, angiotensin II, resistin, tumor necrosis factor-α, interleukin-6, apelin) and/or via local paracrine factors (perivascular adipocyte-derived relaxing and contractile factors). Vascular tone regulation by adipokines is compromised in obesitas and obesity-related disorders. Hypoxia created in growing adipose tissue dysregulates synthesis of vasoactive adipokines in favor of harmful proinflammatory adipokines, while the levels of the cardioprotective adipokines adiponectin and omentin decrease. Considering the potential of the role of adipokines in obesity-related vascular diseases, strategies to counter these diseases by targeting the adipokines are discussed.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Angiotensin II, Interleukin-6, Resistin, Vascular tone, Adipokines, Adipose tissue, Regulator, Obesity, Adipocytes, Vasoactive, Cardiovascular diseases, Circulating hormones, Paracrine mediators, Hypoxia, Leptin, Adiponectin, Apelin, ANGIOTENSIN-II, SMOOTH-MUSCLE-CELLS, ENDOTHELIAL DYSFUNCTION, CARDIOVASCULAR-DISEASE, NECROSIS-FACTOR-ALPHA, Visfatin, Omentin, METABOLIC SYNDROME, NITRIC-OXIDE, ESSENTIAL-HYPERTENSION, INSULIN-RESISTANCE, HYDROGEN-SULFIDE
journal title
CURRENT HYPERTENSION REPORTS
Curr. Hypertens. Rep.
volume
14
issue
3
pages
270 - 278
Web of Science type
Article
Web of Science id
000304855000011
JCR category
PERIPHERAL VASCULAR DISEASE
JCR impact factor
3.744 (2012)
JCR rank
14/66 (2012)
JCR quartile
1 (2012)
ISSN
1522-6417
DOI
10.1007/s11906-012-0259-6
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2138805
handle
http://hdl.handle.net/1854/LU-2138805
date created
2012-06-11 12:28:56
date last changed
2016-12-19 15:42:08
@article{2138805,
  abstract     = {Adipokines secreted by visceral, subcutaneous, and perivascular adipocytes are involved in the regulation of vascular tone by acting as circulatory hormones (leptin, adiponectin, omentin, visfatin, angiotensin II, resistin, tumor necrosis factor-\ensuremath{\alpha}, interleukin-6, apelin) and/or via local paracrine factors (perivascular adipocyte-derived relaxing and contractile factors). Vascular tone regulation by adipokines is compromised in obesitas and obesity-related disorders. Hypoxia created in growing adipose tissue dysregulates synthesis of vasoactive adipokines in favor of harmful proinflammatory adipokines, while the levels of the cardioprotective adipokines adiponectin and omentin decrease. Considering the potential of the role of adipokines in obesity-related vascular diseases, strategies to counter these diseases by targeting the adipokines are discussed.},
  author       = {Boydens, Charlotte and Maenhaut, Nele and Pauwels, Bart and Decaluw{\'e}, Kelly and Van de Voorde, Johan},
  issn         = {1522-6417},
  journal      = {CURRENT HYPERTENSION REPORTS},
  keyword      = {Angiotensin II,Interleukin-6,Resistin,Vascular tone,Adipokines,Adipose tissue,Regulator,Obesity,Adipocytes,Vasoactive,Cardiovascular diseases,Circulating hormones,Paracrine mediators,Hypoxia,Leptin,Adiponectin,Apelin,ANGIOTENSIN-II,SMOOTH-MUSCLE-CELLS,ENDOTHELIAL DYSFUNCTION,CARDIOVASCULAR-DISEASE,NECROSIS-FACTOR-ALPHA,Visfatin,Omentin,METABOLIC SYNDROME,NITRIC-OXIDE,ESSENTIAL-HYPERTENSION,INSULIN-RESISTANCE,HYDROGEN-SULFIDE},
  language     = {eng},
  number       = {3},
  pages        = {270--278},
  title        = {Adipose tissue as regulator of vascular tone},
  url          = {http://dx.doi.org/10.1007/s11906-012-0259-6},
  volume       = {14},
  year         = {2012},
}

Chicago
Boydens, Charlotte, Nele Maenhaut, Bart Pauwels, Kelly Decaluwé, and Johan Van de Voorde. 2012. “Adipose Tissue as Regulator of Vascular Tone.” Current Hypertension Reports 14 (3): 270–278.
APA
Boydens, C., Maenhaut, N., Pauwels, B., Decaluwé, K., & Van de Voorde, J. (2012). Adipose tissue as regulator of vascular tone. CURRENT HYPERTENSION REPORTS, 14(3), 270–278.
Vancouver
1.
Boydens C, Maenhaut N, Pauwels B, Decaluwé K, Van de Voorde J. Adipose tissue as regulator of vascular tone. CURRENT HYPERTENSION REPORTS. 2012;14(3):270–8.
MLA
Boydens, Charlotte, Nele Maenhaut, Bart Pauwels, et al. “Adipose Tissue as Regulator of Vascular Tone.” CURRENT HYPERTENSION REPORTS 14.3 (2012): 270–278. Print.