- Author
- Charlotte Boydens (UGent) , Nele Maenhaut (UGent) , Bart Pauwels (UGent) , Kelly Decaluwé (UGent) and Johan Van de Voorde (UGent)
- Organization
- Abstract
- Adipokines secreted by visceral, subcutaneous, and perivascular adipocytes are involved in the regulation of vascular tone by acting as circulatory hormones (leptin, adiponectin, omentin, visfatin, angiotensin II, resistin, tumor necrosis factor-α, interleukin-6, apelin) and/or via local paracrine factors (perivascular adipocyte-derived relaxing and contractile factors). Vascular tone regulation by adipokines is compromised in obesitas and obesity-related disorders. Hypoxia created in growing adipose tissue dysregulates synthesis of vasoactive adipokines in favor of harmful proinflammatory adipokines, while the levels of the cardioprotective adipokines adiponectin and omentin decrease. Considering the potential of the role of adipokines in obesity-related vascular diseases, strategies to counter these diseases by targeting the adipokines are discussed.
- Keywords
- Angiotensin II, Interleukin-6, Resistin, Vascular tone, Adipokines, Adipose tissue, Regulator, Obesity, Adipocytes, Vasoactive, Cardiovascular diseases, Circulating hormones, Paracrine mediators, Hypoxia, Leptin, Adiponectin, Apelin, ANGIOTENSIN-II, SMOOTH-MUSCLE-CELLS, ENDOTHELIAL DYSFUNCTION, CARDIOVASCULAR-DISEASE, NECROSIS-FACTOR-ALPHA, Visfatin, Omentin, METABOLIC SYNDROME, NITRIC-OXIDE, ESSENTIAL-HYPERTENSION, INSULIN-RESISTANCE, HYDROGEN-SULFIDE
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-2138805
- Chicago
- Boydens, Charlotte, Nele Maenhaut, Bart Pauwels, Kelly Decaluwé, and Johan Van de Voorde. 2012. “Adipose Tissue as Regulator of Vascular Tone.” Current Hypertension Reports 14 (3): 270–278.
- APA
- Boydens, C., Maenhaut, N., Pauwels, B., Decaluwé, K., & Van de Voorde, J. (2012). Adipose tissue as regulator of vascular tone. CURRENT HYPERTENSION REPORTS, 14(3), 270–278.
- Vancouver
- 1.Boydens C, Maenhaut N, Pauwels B, Decaluwé K, Van de Voorde J. Adipose tissue as regulator of vascular tone. CURRENT HYPERTENSION REPORTS. 2012;14(3):270–8.
- MLA
- Boydens, Charlotte, Nele Maenhaut, Bart Pauwels, et al. “Adipose Tissue as Regulator of Vascular Tone.” CURRENT HYPERTENSION REPORTS 14.3 (2012): 270–278. Print.
@article{2138805,
abstract = {Adipokines secreted by visceral, subcutaneous, and perivascular adipocytes are involved in the regulation of vascular tone by acting as circulatory hormones (leptin, adiponectin, omentin, visfatin, angiotensin II, resistin, tumor necrosis factor-\ensuremath{\alpha}, interleukin-6, apelin) and/or via local paracrine factors (perivascular adipocyte-derived relaxing and contractile factors). Vascular tone regulation by adipokines is compromised in obesitas and obesity-related disorders. Hypoxia created in growing adipose tissue dysregulates synthesis of vasoactive adipokines in favor of harmful proinflammatory adipokines, while the levels of the cardioprotective adipokines adiponectin and omentin decrease. Considering the potential of the role of adipokines in obesity-related vascular diseases, strategies to counter these diseases by targeting the adipokines are discussed.},
author = {Boydens, Charlotte and Maenhaut, Nele and Pauwels, Bart and Decaluw{\'e}, Kelly and Van de Voorde, Johan},
issn = {1522-6417},
journal = {CURRENT HYPERTENSION REPORTS},
keyword = {Angiotensin II,Interleukin-6,Resistin,Vascular tone,Adipokines,Adipose tissue,Regulator,Obesity,Adipocytes,Vasoactive,Cardiovascular diseases,Circulating hormones,Paracrine mediators,Hypoxia,Leptin,Adiponectin,Apelin,ANGIOTENSIN-II,SMOOTH-MUSCLE-CELLS,ENDOTHELIAL DYSFUNCTION,CARDIOVASCULAR-DISEASE,NECROSIS-FACTOR-ALPHA,Visfatin,Omentin,METABOLIC SYNDROME,NITRIC-OXIDE,ESSENTIAL-HYPERTENSION,INSULIN-RESISTANCE,HYDROGEN-SULFIDE},
language = {eng},
number = {3},
pages = {270--278},
title = {Adipose tissue as regulator of vascular tone},
url = {http://dx.doi.org/10.1007/s11906-012-0259-6},
volume = {14},
year = {2012},
}
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