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Combined impact of mucosal damage and of cystic fibrosis on the small intestinal brush border enzyme activities

Stephanie Van Biervliet UGent, Ephrem Eggermont, Paul Mariën, Ilse Hoffman and Gigi Veereman (2003) ACTA CLINICA BELGICA. 58(4). p.220-224
abstract
In 61 cystic fibrosis (CF) patients, the small intestinal mucosa was studied at the time of diagnosis before starting therapy. In 19 out of 61 patients, partial villous atrophy on light microscopy and shortened villi on stereomicroscopic examination were seen. On the biopsy specimens, maltase, sucrase, lactase and alkaline phosphatase activities were studied. Comparison of the enzymatic activities in CF patients having damaged mucosa and a group of patients having similar mucosal lesions of unspecified origin (UTID), reveals a significantly more pronounced decrease of the alkaline phosphatase activity (p<0.005) in the CF patients. This is in agreement with previous reported results in CF patients with normal mucosa. The abnormal mucosal findings could be due to the decreased neutralization of the gastric content delivered into the duodenum, the early inflammatory reaction present in the CF mucosa and/or to the impaired synthesis of membrane glycoproteins and enzymes secondary to the CFTR mutation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
small intestinal mucosa damage, cystic fibrosis, chymotrypsin, amylase, sucrase, maltase, lactase, intestinal alkaline phosphatase, PANCREATIC-ENZYMES, VILLOUS ATROPHY, INFANTS, DISEASE
journal title
ACTA CLINICA BELGICA
Acta Clin. Belg.
volume
58
issue
4
pages
220 - 224
Web of Science type
Article
Web of Science id
000220010300002
JCR category
MEDICINE, GENERAL & INTERNAL
JCR impact factor
0.395 (2003)
JCR rank
77/102 (2003)
JCR quartile
3 (2003)
ISSN
0001-5512
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
213811
handle
http://hdl.handle.net/1854/LU-213811
date created
2004-04-30 17:03:00
date last changed
2016-12-19 15:39:03
@article{213811,
  abstract     = {In 61 cystic fibrosis (CF) patients, the small intestinal mucosa was studied at the time of diagnosis before starting therapy. In 19 out of 61 patients, partial villous atrophy on light microscopy and shortened villi on stereomicroscopic examination were seen. On the biopsy specimens, maltase, sucrase, lactase and alkaline phosphatase activities were studied. Comparison of the enzymatic activities in CF patients having damaged mucosa and a group of patients having similar mucosal lesions of unspecified origin (UTID), reveals a significantly more pronounced decrease of the alkaline phosphatase activity (p{\textlangle}0.005) in the CF patients. This is in agreement with previous reported results in CF patients with normal mucosa. 
The abnormal mucosal findings could be due to the decreased neutralization of the gastric content delivered into the duodenum, the early inflammatory reaction present in the CF mucosa and/or to the impaired synthesis of membrane glycoproteins and enzymes secondary to the CFTR mutation.},
  author       = {Van Biervliet, Stephanie and Eggermont, Ephrem and Mari{\"e}n, Paul and Hoffman, Ilse and Veereman, Gigi},
  issn         = {0001-5512},
  journal      = {ACTA CLINICA BELGICA},
  keyword      = {small intestinal mucosa damage,cystic fibrosis,chymotrypsin,amylase,sucrase,maltase,lactase,intestinal alkaline phosphatase,PANCREATIC-ENZYMES,VILLOUS ATROPHY,INFANTS,DISEASE},
  language     = {eng},
  number       = {4},
  pages        = {220--224},
  title        = {Combined impact of mucosal damage and of cystic fibrosis on the small intestinal brush border enzyme activities},
  volume       = {58},
  year         = {2003},
}

Chicago
Van Biervliet, Stephanie, Ephrem Eggermont, Paul Mariën, Ilse Hoffman, and Gigi Veereman. 2003. “Combined Impact of Mucosal Damage and of Cystic Fibrosis on the Small Intestinal Brush Border Enzyme Activities.” Acta Clinica Belgica 58 (4): 220–224.
APA
Van Biervliet, Stephanie, Eggermont, E., Mariën, P., Hoffman, I., & Veereman, G. (2003). Combined impact of mucosal damage and of cystic fibrosis on the small intestinal brush border enzyme activities. ACTA CLINICA BELGICA, 58(4), 220–224.
Vancouver
1.
Van Biervliet S, Eggermont E, Mariën P, Hoffman I, Veereman G. Combined impact of mucosal damage and of cystic fibrosis on the small intestinal brush border enzyme activities. ACTA CLINICA BELGICA. 2003;58(4):220–4.
MLA
Van Biervliet, Stephanie, Ephrem Eggermont, Paul Mariën, et al. “Combined Impact of Mucosal Damage and of Cystic Fibrosis on the Small Intestinal Brush Border Enzyme Activities.” ACTA CLINICA BELGICA 58.4 (2003): 220–224. Print.