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Pharmacokinetics of two formulations of omeprazole administered through a gastrostomy tube in patients with severe neurodevelopmental problems

Koen Boussery (UGent) , Julie De Smet (UGent) , Pieter De Cock (UGent) , Saskia Vande Velde (UGent) , Els Mehuys (UGent) , Peter De Paepe (UGent) , Jean Paul Remon (UGent) , Jan Van Bocxlaer (UGent) and Myriam Van Winckel (UGent)
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Abstract
AIMS Omeprazole is often administered through a gastrostomy tube as either (i) a Multiple Unit Pellet System (MUPS (R)) tablet disintegrated in water (MUPS (R) formulation), or (ii) a suspension in 8.4% sodium bicarbonate (suspension formulation). This bioavailability study evaluates this practice in tube-fed patients with severe neurodevelopmental problems. METHODS Nonblinded, two-phase cross-over trial. RESULTS In seven of 10 patients, bioavailability was higher for the suspension formulation than for the MUPS (R) formulation. Median (90% confidence interval) area under the plasma concentration-time curve ratio (MUPS (R) over suspension) was 0.5 (0.06-2.37). CONCLUSIONS In this population, omeprazole MUPS (R) formulation has no apparent advantage over the more easily administered suspension formulation.
Keywords
PROTON PUMP INHIBITORS, CHILDREN, proton pump inhibitor, omeprazole, neurodevelopmental problem, feeding tube, cerebral palsy, bioavailability, SINGLE, LANSOPRAZOLE, THERAPY

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Chicago
Boussery, Koen, Julie De Smet, Pieter De Cock, Saskia Vande Velde, Els Mehuys, Peter De Paepe, Jean Paul Remon, Jan Van Bocxlaer, and Myriam Van Winckel. 2011. “Pharmacokinetics of Two Formulations of Omeprazole Administered Through a Gastrostomy Tube in Patients with Severe Neurodevelopmental Problems.” British Journal of Clinical Pharmacology 72 (6): 990–996.
APA
Boussery, Koen, De Smet, J., De Cock, P., Vande Velde, S., Mehuys, E., De Paepe, P., Remon, J. P., et al. (2011). Pharmacokinetics of two formulations of omeprazole administered through a gastrostomy tube in patients with severe neurodevelopmental problems. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 72(6), 990–996.
Vancouver
1.
Boussery K, De Smet J, De Cock P, Vande Velde S, Mehuys E, De Paepe P, et al. Pharmacokinetics of two formulations of omeprazole administered through a gastrostomy tube in patients with severe neurodevelopmental problems. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2011;72(6):990–6.
MLA
Boussery, Koen, Julie De Smet, Pieter De Cock, et al. “Pharmacokinetics of Two Formulations of Omeprazole Administered Through a Gastrostomy Tube in Patients with Severe Neurodevelopmental Problems.” BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 72.6 (2011): 990–996. Print.
@article{2137716,
  abstract     = {AIMS Omeprazole is often administered through a gastrostomy tube as either (i) a Multiple Unit Pellet System (MUPS (R)) tablet disintegrated in water (MUPS (R) formulation), or (ii) a suspension in 8.4\% sodium bicarbonate (suspension formulation). This bioavailability study evaluates this practice in tube-fed patients with severe neurodevelopmental problems. 
METHODS Nonblinded, two-phase cross-over trial. 
RESULTS In seven of 10 patients, bioavailability was higher for the suspension formulation than for the MUPS (R) formulation. Median (90\% confidence interval) area under the plasma concentration-time curve ratio (MUPS (R) over suspension) was 0.5 (0.06-2.37). 
CONCLUSIONS In this population, omeprazole MUPS (R) formulation has no apparent advantage over the more easily administered suspension formulation.},
  author       = {Boussery, Koen and De Smet, Julie and De Cock, Pieter and Vande Velde, Saskia and Mehuys, Els and De Paepe, Peter and Remon, Jean Paul and Van Bocxlaer, Jan and Van Winckel, Myriam},
  issn         = {0306-5251},
  journal      = {BRITISH JOURNAL OF CLINICAL PHARMACOLOGY},
  keyword      = {PROTON PUMP INHIBITORS,CHILDREN,proton pump inhibitor,omeprazole,neurodevelopmental problem,feeding tube,cerebral palsy,bioavailability,SINGLE,LANSOPRAZOLE,THERAPY},
  language     = {eng},
  number       = {6},
  pages        = {990--996},
  title        = {Pharmacokinetics of two formulations of omeprazole administered through a gastrostomy tube in patients with severe neurodevelopmental problems},
  url          = {http://dx.doi.org/10.1111/j.1365-2125.2011.04038.x},
  volume       = {72},
  year         = {2011},
}

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