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Absolute quantification in multi-pinhole micro-SPECT for different isotopes

Bert Vandeghinste UGent, Christian Vanhove UGent, Jan De Beenhouwer UGent, Roel Van Holen UGent, Stefaan Vandenberghe UGent and Steven Staelens UGent (2011) IEEE Nuclear Science Symposium Conference Record. p.3720-3724
abstract
In preclinical Single Photon Emission Tomography (SPECT), absolute quantification is interesting, expressed in percentage of injected radioactive dose per gram of tissue. This allows for accurate evaluation of disease progression and precise follow-up studies without the need for sacrificing animals. Accurate modeling of image degrading effects is currently under development for isotopes different from 99mTc. The aim of this work is to develop absolute micro-SPECT quantification for three different isotopes: 99mTc, 111In and 125I. This selection of isotopes covers a wide range of energies, is pre-clinically relevant and allows us to optimally validate the algorithms used for image reconstruction. Furthermore, we will mix these isotopes with additional iodine-based CT contrast agent, to mimic contrast-enhanced SPECT/CT protocols. For each isotope, both a calibration phantom and three 1-ml vials were scanned on the CZT-based FLEX Triumph-I scanner (GM-I). The calibration phantom allows the conversion of reconstructed voxel counts to MBq/ml. The 3-vial phantom consists of 3 different concentrations of radioactivity. Two vials contain iodine-based CT contrast agent to significantly increase the attenuation. All datasets were reconstructed using a GPU-based reconstruction algorithm, which includes resolution recovery, pinhole penetration, geometrical sensitivity correction, scatter correction and attenuation correction. We show good quantification for 99mTc and 111In. The absolute quantification of I is suboptimal, due to insufficient scatter correction. No influence can be seen when iodine-based CT contrast agent is used together with 125I.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
SCATTER CORRECTION, OPTIMIZATION, IN-111
in
IEEE Nuclear Science Symposium Conference Record
issue title
2011 IEEE Nuclear science symposium and medical imaging conference (NSS/MIC)
article_number
12574740
pages
3720 - 3724
publisher
IEEE
place of publication
Piscataway, NJ, USA
conference name
2011 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC 2011)
conference location
Valencia, Spain
conference start
2011-10-23
conference end
2011-10-29
Web of Science type
Proceedings Paper
Web of Science id
000304755603213
ISSN
1082-3654
ISBN
9781467301206
DOI
10.1109/NSSMIC.2011.6153702
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
P1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2132875
handle
http://hdl.handle.net/1854/LU-2132875
date created
2012-06-05 14:05:40
date last changed
2013-02-27 09:09:13
@inproceedings{2132875,
  abstract     = {In preclinical Single Photon Emission Tomography (SPECT), absolute quantification is interesting, expressed in percentage of injected radioactive dose per gram of tissue. This allows for accurate evaluation of disease progression and precise follow-up studies without the need for sacrificing animals. Accurate modeling of image degrading effects is currently under development for isotopes different from 99mTc. The aim of this work is to develop absolute micro-SPECT quantification for three different isotopes: 99mTc, 111In and 125I. This selection of isotopes covers a wide range of energies, is pre-clinically relevant and allows us to optimally validate the algorithms used for image reconstruction. Furthermore, we will mix these isotopes with additional iodine-based CT contrast agent, to mimic contrast-enhanced SPECT/CT protocols. For each isotope, both a calibration phantom and three 1-ml vials were scanned on the CZT-based FLEX Triumph-I scanner (GM-I). The calibration phantom allows the conversion of reconstructed voxel counts to MBq/ml. The 3-vial phantom consists of 3 different concentrations of radioactivity. Two vials contain iodine-based CT contrast agent to significantly increase the attenuation. All datasets were reconstructed using a GPU-based reconstruction algorithm, which includes resolution recovery, pinhole penetration, geometrical sensitivity correction, scatter correction and attenuation correction. We show good quantification for 99mTc and 111In. The absolute quantification of I is suboptimal, due to insufficient scatter correction. No influence can be seen when iodine-based CT contrast agent is used together with 125I.},
  articleno    = {12574740},
  author       = {Vandeghinste, Bert and Vanhove, Christian and De Beenhouwer, Jan and Van Holen, Roel and Vandenberghe, Stefaan and Staelens, Steven},
  booktitle    = {IEEE Nuclear Science Symposium Conference Record},
  isbn         = {9781467301206},
  issn         = {1082-3654},
  keyword      = {SCATTER CORRECTION,OPTIMIZATION,IN-111},
  language     = {eng},
  location     = {Valencia, Spain},
  pages        = {12574740:3720--12574740:3724},
  publisher    = {IEEE},
  title        = {Absolute quantification in multi-pinhole micro-SPECT for different isotopes},
  url          = {http://dx.doi.org/10.1109/NSSMIC.2011.6153702},
  year         = {2011},
}

Chicago
Vandeghinste, Bert, Christian Vanhove, Jan De Beenhouwer, Roel Van Holen, Stefaan Vandenberghe, and Steven Staelens. 2011. “Absolute Quantification in Multi-pinhole micro-SPECT for Different Isotopes.” In IEEE Nuclear Science Symposium Conference Record, 3720–3724. Piscataway, NJ, USA: IEEE.
APA
Vandeghinste, B., Vanhove, C., De Beenhouwer, J., Van Holen, R., Vandenberghe, S., & Staelens, S. (2011). Absolute quantification in multi-pinhole micro-SPECT for different isotopes. IEEE Nuclear Science Symposium Conference Record (pp. 3720–3724). Presented at the 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC 2011), Piscataway, NJ, USA: IEEE.
Vancouver
1.
Vandeghinste B, Vanhove C, De Beenhouwer J, Van Holen R, Vandenberghe S, Staelens S. Absolute quantification in multi-pinhole micro-SPECT for different isotopes. IEEE Nuclear Science Symposium Conference Record. Piscataway, NJ, USA: IEEE; 2011. p. 3720–4.
MLA
Vandeghinste, Bert, Christian Vanhove, Jan De Beenhouwer, et al. “Absolute Quantification in Multi-pinhole micro-SPECT for Different Isotopes.” IEEE Nuclear Science Symposium Conference Record. Piscataway, NJ, USA: IEEE, 2011. 3720–3724. Print.