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Brainpeps: the blood-brain barrier peptide database

Sylvia Van Dorpe UGent, Antoon Bronselaer UGent, Joachim Nielandt UGent, Sofie Stalmans UGent, Evelien Wynendaele UGent, Kurt Audenaert UGent, Christophe Van De Wiele UGent, Christian Burvenich UGent, Kathelijne Peremans UGent and Hung Hsuchou, et al. (2012) BRAIN STRUCTURE & FUNCTION. 217(3). p.687-718
abstract
Peptides are able to cross the blood-brain barrier (BBB) through various mechanisms, opening new diagnostic and therapeutic avenues. However, their BBB-transport data are scattered in the literature over different disciplines, using different methodologies reporting different influx or efflux aspects. Therefore, a comprehensive BBB peptide database (Brainpeps) was constructed to collect the BBB-data available in the literature. Brainpeps currently contains BBB transport information with positive as well as negative results. The database is a useful tool to prioritise peptide choices for evaluating different BBB-responses or studying quantitative structure - property (BBB behaviour) relationships of peptides. Because a multitude of methods have been used to assess the BBB behaviour of compounds, we classified these methods and their responses. Moreover, the relationships between the different BBB transport methods have been clarified and visualised.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
CENTRAL-NERVOUS-SYSTEM, IN-VITRO MODELS, blood-brain barrier, database, Peptide, ARTIFICIAL MEMBRANE CHROMATOGRAPHY, INTERNAL REFERENCE TECHNIQUE, CACO-2 CELL-PERMEABILITY, SLEEP-INDUCING PEPTIDE, EFFLUX INDEX METHOD, CNS DRUG-DELIVERY, RAT-BRAIN, ENDOTHELIAL-CELLS
journal title
BRAIN STRUCTURE & FUNCTION
Brain Struct. Funct.
volume
217
issue
3
pages
687 - 718
Web of Science type
Review
Web of Science id
000305681000001
JCR category
ANATOMY & MORPHOLOGY
JCR impact factor
7.837 (2012)
JCR rank
1/20 (2012)
JCR quartile
1 (2012)
ISSN
1863-2653
DOI
10.1007/s00429-011-0375-0
project
The integrative neuroscience of behavioral control (Neuroscience)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2132013
handle
http://hdl.handle.net/1854/LU-2132013
date created
2012-06-04 17:01:35
date last changed
2015-06-17 10:04:29
@article{2132013,
  abstract     = {Peptides are able to cross the blood-brain barrier (BBB) through various mechanisms, opening new diagnostic and therapeutic avenues. However, their BBB-transport data are scattered in the literature over different disciplines, using different methodologies reporting different influx or efflux aspects. Therefore, a comprehensive BBB peptide database (Brainpeps) was constructed to collect the BBB-data available in the literature. Brainpeps currently contains BBB transport information with positive as well as negative results. The database is a useful tool to prioritise peptide choices for evaluating different BBB-responses or studying quantitative structure - property (BBB behaviour) relationships of peptides. Because a multitude of methods have been used to assess the BBB behaviour of compounds, we classified these methods and their responses. Moreover, the relationships between the different BBB transport methods have been clarified and visualised.},
  author       = {Van Dorpe, Sylvia and Bronselaer, Antoon and Nielandt, Joachim and Stalmans, Sofie and Wynendaele, Evelien and Audenaert, Kurt and Van De Wiele, Christophe and Burvenich, Christian and Peremans, Kathelijne and Hsuchou, Hung and De Tr{\'e}, Guy and De Spiegeleer, Bart},
  issn         = {1863-2653},
  journal      = {BRAIN STRUCTURE \& FUNCTION},
  keyword      = {CENTRAL-NERVOUS-SYSTEM,IN-VITRO MODELS,blood-brain barrier,database,Peptide,ARTIFICIAL MEMBRANE CHROMATOGRAPHY,INTERNAL REFERENCE TECHNIQUE,CACO-2 CELL-PERMEABILITY,SLEEP-INDUCING PEPTIDE,EFFLUX INDEX METHOD,CNS DRUG-DELIVERY,RAT-BRAIN,ENDOTHELIAL-CELLS},
  language     = {eng},
  number       = {3},
  pages        = {687--718},
  title        = {Brainpeps: the blood-brain barrier peptide database},
  url          = {http://dx.doi.org/10.1007/s00429-011-0375-0},
  volume       = {217},
  year         = {2012},
}

Chicago
Van Dorpe, Sylvia, Antoon Bronselaer, Joachim Nielandt, Sofie Stalmans, Evelien Wynendaele, Kurt Audenaert, Christophe Van De Wiele, et al. 2012. “Brainpeps: The Blood-brain Barrier Peptide Database.” Brain Structure & Function 217 (3): 687–718.
APA
Van Dorpe, S., Bronselaer, A., Nielandt, J., Stalmans, S., Wynendaele, E., Audenaert, K., Van De Wiele, C., et al. (2012). Brainpeps: the blood-brain barrier peptide database. BRAIN STRUCTURE & FUNCTION, 217(3), 687–718.
Vancouver
1.
Van Dorpe S, Bronselaer A, Nielandt J, Stalmans S, Wynendaele E, Audenaert K, et al. Brainpeps: the blood-brain barrier peptide database. BRAIN STRUCTURE & FUNCTION. 2012;217(3):687–718.
MLA
Van Dorpe, Sylvia, Antoon Bronselaer, Joachim Nielandt, et al. “Brainpeps: The Blood-brain Barrier Peptide Database.” BRAIN STRUCTURE & FUNCTION 217.3 (2012): 687–718. Print.