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Brainpeps: the blood-brain barrier peptide database

(2012) BRAIN STRUCTURE & FUNCTION. 217(3). p.687-718
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The integrative neuroscience of behavioral control (Neuroscience)
Abstract
Peptides are able to cross the blood-brain barrier (BBB) through various mechanisms, opening new diagnostic and therapeutic avenues. However, their BBB-transport data are scattered in the literature over different disciplines, using different methodologies reporting different influx or efflux aspects. Therefore, a comprehensive BBB peptide database (Brainpeps) was constructed to collect the BBB-data available in the literature. Brainpeps currently contains BBB transport information with positive as well as negative results. The database is a useful tool to prioritise peptide choices for evaluating different BBB-responses or studying quantitative structure - property (BBB behaviour) relationships of peptides. Because a multitude of methods have been used to assess the BBB behaviour of compounds, we classified these methods and their responses. Moreover, the relationships between the different BBB transport methods have been clarified and visualised.
Keywords
CENTRAL-NERVOUS-SYSTEM, IN-VITRO MODELS, blood-brain barrier, database, Peptide, ARTIFICIAL MEMBRANE CHROMATOGRAPHY, INTERNAL REFERENCE TECHNIQUE, CACO-2 CELL-PERMEABILITY, SLEEP-INDUCING PEPTIDE, EFFLUX INDEX METHOD, CNS DRUG-DELIVERY, RAT-BRAIN, ENDOTHELIAL-CELLS

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Citation

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Chicago
Van Dorpe, Sylvia, Antoon Bronselaer, Joachim Nielandt, Sofie Stalmans, Evelien Wynendaele, Kurt Audenaert, Christophe Van De Wiele, et al. 2012. “Brainpeps: The Blood-brain Barrier Peptide Database.” Brain Structure & Function 217 (3): 687–718.
APA
Van Dorpe, S., Bronselaer, A., Nielandt, J., Stalmans, S., Wynendaele, E., Audenaert, K., Van De Wiele, C., et al. (2012). Brainpeps: the blood-brain barrier peptide database. BRAIN STRUCTURE & FUNCTION, 217(3), 687–718.
Vancouver
1.
Van Dorpe S, Bronselaer A, Nielandt J, Stalmans S, Wynendaele E, Audenaert K, et al. Brainpeps: the blood-brain barrier peptide database. BRAIN STRUCTURE & FUNCTION. 2012;217(3):687–718.
MLA
Van Dorpe, Sylvia, Antoon Bronselaer, Joachim Nielandt, et al. “Brainpeps: The Blood-brain Barrier Peptide Database.” BRAIN STRUCTURE & FUNCTION 217.3 (2012): 687–718. Print.
@article{2132013,
  abstract     = {Peptides are able to cross the blood-brain barrier (BBB) through various mechanisms, opening new diagnostic and therapeutic avenues. However, their BBB-transport data are scattered in the literature over different disciplines, using different methodologies reporting different influx or efflux aspects. Therefore, a comprehensive BBB peptide database (Brainpeps) was constructed to collect the BBB-data available in the literature. Brainpeps currently contains BBB transport information with positive as well as negative results. The database is a useful tool to prioritise peptide choices for evaluating different BBB-responses or studying quantitative structure - property (BBB behaviour) relationships of peptides. Because a multitude of methods have been used to assess the BBB behaviour of compounds, we classified these methods and their responses. Moreover, the relationships between the different BBB transport methods have been clarified and visualised.},
  author       = {Van Dorpe, Sylvia and Bronselaer, Antoon and Nielandt, Joachim and Stalmans, Sofie and Wynendaele, Evelien and Audenaert, Kurt and Van De Wiele, Christophe and Burvenich, Christian and Peremans, Kathelijne and Hsuchou, Hung and De Tré, Guy and De Spiegeleer, Bart},
  issn         = {1863-2653},
  journal      = {BRAIN STRUCTURE & FUNCTION},
  keywords     = {CENTRAL-NERVOUS-SYSTEM,IN-VITRO MODELS,blood-brain barrier,database,Peptide,ARTIFICIAL MEMBRANE CHROMATOGRAPHY,INTERNAL REFERENCE TECHNIQUE,CACO-2 CELL-PERMEABILITY,SLEEP-INDUCING PEPTIDE,EFFLUX INDEX METHOD,CNS DRUG-DELIVERY,RAT-BRAIN,ENDOTHELIAL-CELLS},
  language     = {eng},
  number       = {3},
  pages        = {687--718},
  title        = {Brainpeps: the blood-brain barrier peptide database},
  url          = {http://dx.doi.org/10.1007/s00429-011-0375-0},
  volume       = {217},
  year         = {2012},
}

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