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Particulate vaccines: on the quest for optimal delivery and immune response

(2011) DRUG DISCOVERY TODAY. 16(13-14). p.569-582
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Abstract
Subunit vaccines offer a safer alternative to traditional organism-based vaccines, but their immunogenicity is impaired. This hurdle might be overcome by the use of micro- and nanodelivery systems carrying the antigen(s). This review discusses the rationale for the use of particulate vaccines and provides an overview of antigen-delivery vehicles currently under investigation. It further highlights the cellular uptake, antigen processing and the presentation by antigen-presenting cells because these processes are partially governed by particle characteristics and eventually determine the immunological outcome. Finally, we address the attractive concept of concomitant delivery of antigens and immunopotentiators. The condensed knowledge could be an asset for rationally designing antigen-delivery vehicles to obtain safe and efficacious vaccines.
Keywords
MHC CLASS-I, HUMAN DENDRITIC CELLS, ANTIGEN-PRESENTING CELLS, CYTOTOXIC T-LYMPHOCYTES, SURFACE-MODIFIED MICROPARTICLES, EFFICIENT CROSS-PRESENTATION, MONOPHOSPHORYL-LIPID-A, HEPATITIS-B-VACCINE, INFLUENZA VACCINE, POLYELECTROLYTE MICROCAPSULES

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Citation

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Chicago
De Temmerman, Marie-Luce, Joanna Rejman, Jo Demeester, Darrell J Irvine, Bruno Gander, and Stefaan De Smedt. 2011. “Particulate Vaccines: On the Quest for Optimal Delivery and Immune Response.” Drug Discovery Today 16 (13-14): 569–582.
APA
De Temmerman, M.-L., Rejman, J., Demeester, J., Irvine, D. J., Gander, B., & De Smedt, S. (2011). Particulate vaccines: on the quest for optimal delivery and immune response. DRUG DISCOVERY TODAY, 16(13-14), 569–582.
Vancouver
1.
De Temmerman M-L, Rejman J, Demeester J, Irvine DJ, Gander B, De Smedt S. Particulate vaccines: on the quest for optimal delivery and immune response. DRUG DISCOVERY TODAY. 2011;16(13-14):569–82.
MLA
De Temmerman, Marie-Luce, Joanna Rejman, Jo Demeester, et al. “Particulate Vaccines: On the Quest for Optimal Delivery and Immune Response.” DRUG DISCOVERY TODAY 16.13-14 (2011): 569–582. Print.
@article{2131373,
  abstract     = {Subunit vaccines offer a safer alternative to traditional organism-based vaccines, but their immunogenicity is impaired. This hurdle might be overcome by the use of micro- and nanodelivery systems carrying the antigen(s). This review discusses the rationale for the use of particulate vaccines and provides an overview of antigen-delivery vehicles currently under investigation. It further highlights the cellular uptake, antigen processing and the presentation by antigen-presenting cells because these processes are partially governed by particle characteristics and eventually determine the immunological outcome. Finally, we address the attractive concept of concomitant delivery of antigens and immunopotentiators. The condensed knowledge could be an asset for rationally designing antigen-delivery vehicles to obtain safe and efficacious vaccines.},
  author       = {De Temmerman, Marie-Luce and Rejman, Joanna and Demeester, Jo and Irvine, Darrell J and Gander, Bruno and De Smedt, Stefaan},
  issn         = {1359-6446},
  journal      = {DRUG DISCOVERY TODAY},
  keyword      = {MHC CLASS-I,HUMAN DENDRITIC CELLS,ANTIGEN-PRESENTING CELLS,CYTOTOXIC T-LYMPHOCYTES,SURFACE-MODIFIED MICROPARTICLES,EFFICIENT CROSS-PRESENTATION,MONOPHOSPHORYL-LIPID-A,HEPATITIS-B-VACCINE,INFLUENZA VACCINE,POLYELECTROLYTE MICROCAPSULES},
  language     = {eng},
  number       = {13-14},
  pages        = {569--582},
  title        = {Particulate vaccines: on the quest for optimal delivery and immune response},
  url          = {http://dx.doi.org/10.1016/j.drudis.2011.04.006},
  volume       = {16},
  year         = {2011},
}

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