Ghent University Academic Bibliography

Advanced

Particulate vaccines: on the quest for optimal delivery and immune response

Marie-Luce De Temmerman UGent, Joanna Rejman UGent, Jo Demeester UGent, Darrell J Irvine, Bruno Gander and Stefaan De Smedt UGent (2011) DRUG DISCOVERY TODAY. 16(13-14). p.569-582
abstract
Subunit vaccines offer a safer alternative to traditional organism-based vaccines, but their immunogenicity is impaired. This hurdle might be overcome by the use of micro- and nanodelivery systems carrying the antigen(s). This review discusses the rationale for the use of particulate vaccines and provides an overview of antigen-delivery vehicles currently under investigation. It further highlights the cellular uptake, antigen processing and the presentation by antigen-presenting cells because these processes are partially governed by particle characteristics and eventually determine the immunological outcome. Finally, we address the attractive concept of concomitant delivery of antigens and immunopotentiators. The condensed knowledge could be an asset for rationally designing antigen-delivery vehicles to obtain safe and efficacious vaccines.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
MHC CLASS-I, HUMAN DENDRITIC CELLS, ANTIGEN-PRESENTING CELLS, CYTOTOXIC T-LYMPHOCYTES, SURFACE-MODIFIED MICROPARTICLES, EFFICIENT CROSS-PRESENTATION, MONOPHOSPHORYL-LIPID-A, HEPATITIS-B-VACCINE, INFLUENZA VACCINE, POLYELECTROLYTE MICROCAPSULES
journal title
DRUG DISCOVERY TODAY
Drug Discov. Today
volume
16
issue
13-14
pages
569 - 582
Web of Science type
Review
Web of Science id
000292719200005
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
6.828 (2011)
JCR rank
11/259 (2011)
JCR quartile
1 (2011)
ISSN
1359-6446
DOI
10.1016/j.drudis.2011.04.006
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2131373
handle
http://hdl.handle.net/1854/LU-2131373
date created
2012-06-04 15:11:12
date last changed
2012-06-08 14:35:14
@article{2131373,
  abstract     = {Subunit vaccines offer a safer alternative to traditional organism-based vaccines, but their immunogenicity is impaired. This hurdle might be overcome by the use of micro- and nanodelivery systems carrying the antigen(s). This review discusses the rationale for the use of particulate vaccines and provides an overview of antigen-delivery vehicles currently under investigation. It further highlights the cellular uptake, antigen processing and the presentation by antigen-presenting cells because these processes are partially governed by particle characteristics and eventually determine the immunological outcome. Finally, we address the attractive concept of concomitant delivery of antigens and immunopotentiators. The condensed knowledge could be an asset for rationally designing antigen-delivery vehicles to obtain safe and efficacious vaccines.},
  author       = {De Temmerman, Marie-Luce and Rejman, Joanna and Demeester, Jo and Irvine, Darrell J and Gander, Bruno and De Smedt, Stefaan},
  issn         = {1359-6446},
  journal      = {DRUG DISCOVERY TODAY},
  keyword      = {MHC CLASS-I,HUMAN DENDRITIC CELLS,ANTIGEN-PRESENTING CELLS,CYTOTOXIC T-LYMPHOCYTES,SURFACE-MODIFIED MICROPARTICLES,EFFICIENT CROSS-PRESENTATION,MONOPHOSPHORYL-LIPID-A,HEPATITIS-B-VACCINE,INFLUENZA VACCINE,POLYELECTROLYTE MICROCAPSULES},
  language     = {eng},
  number       = {13-14},
  pages        = {569--582},
  title        = {Particulate vaccines: on the quest for optimal delivery and immune response},
  url          = {http://dx.doi.org/10.1016/j.drudis.2011.04.006},
  volume       = {16},
  year         = {2011},
}

Chicago
De Temmerman, Marie-Luce, Joanna Rejman, Jo Demeester, Darrell J Irvine, Bruno Gander, and Stefaan De Smedt. 2011. “Particulate Vaccines: On the Quest for Optimal Delivery and Immune Response.” Drug Discovery Today 16 (13-14): 569–582.
APA
De Temmerman, M.-L., Rejman, J., Demeester, J., Irvine, D. J., Gander, B., & De Smedt, S. (2011). Particulate vaccines: on the quest for optimal delivery and immune response. DRUG DISCOVERY TODAY, 16(13-14), 569–582.
Vancouver
1.
De Temmerman M-L, Rejman J, Demeester J, Irvine DJ, Gander B, De Smedt S. Particulate vaccines: on the quest for optimal delivery and immune response. DRUG DISCOVERY TODAY. 2011;16(13-14):569–82.
MLA
De Temmerman, Marie-Luce, Joanna Rejman, Jo Demeester, et al. “Particulate Vaccines: On the Quest for Optimal Delivery and Immune Response.” DRUG DISCOVERY TODAY 16.13-14 (2011): 569–582. Print.