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An analysis of timing and frequency of malaria infection during pregnancy in relation to the risk of low birth weight, anaemia and perinatal mortality in Burkina Faso

Innocent Valea, Halidou Tinto, Maxime Drabo, Lieven Huybregts UGent, Hermann Sorgho, Jean-Bosco Ouedraogo, Robert Guiguemde, Jean Pierre Van Geertruyden, Patrick Kolsteren UGent and Umberto D'Allessandro (2012) MALARIA JOURNAL. 11.
abstract
Background: A prospective study aiming at assessing the effect of adding a third dose sulphadoxine-pyrimethamine (SP) to the standard two-dose intermittent preventive treatment for pregnant women was carried out in Hounde, Burkina Faso, between March 2006 and July 2008. Pregnant women were identified as earlier as possible during pregnancy through a network of home visitors, referred to the health facilities for inclusion and followed up until delivery. Methods: Study participants were enrolled at antenatal care (ANC) visits and randomized to receive either two or three doses of SP at the appropriate time. Women were visited daily and a blood slide was collected when there was fever (body temperature > 37.5 degrees C) or history of fever. Women were encouraged to attend ANC and deliver in the health centre, where the new-born was examined and weighed. The timing and frequency of malaria infection was analysed in relation to the risk of low birth weight, maternal anaemia and perinatal mortality. Results: Data on birth weight and haemoglobin were available for 1,034 women. The incidence of malaria infections was significantly lower in women having received three instead of two doses of SP. Occurrence of first malaria infection during the first or second trimester was associated with a higher risk of low birth weight: incidence rate ratios of 3.56 (p < 0.001) and 1.72 (p = 0.034), respectively. After adjusting for possible confounding factors, the risk remained significantly higher for the infection in the first trimester of pregnancy (adjusted incidence rate ratio = 2.07, p = 0.002). The risk of maternal anaemia and perinatal mortality was not associated with the timing of first malaria infection. Conclusion: Malaria infection during first trimester of pregnancy is associated to a higher risk of low birth weight. Women should be encouraged to use long-lasting insecticidal nets before and throughout their pregnancy.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SULFADOXINE-PYRIMETHAMINE, IPT, INTERMITTENT PREVENTIVE TREATMENT, Pregnancy, Malaria infection, Sulphadoxine-pyrimethamine, First trimester, KOUPELA DISTRICT, AFRICA, BURDEN, PATHOGENESIS, IMMUNITY, PROGRAM, IMPACT
journal title
MALARIA JOURNAL
Malar. J.
volume
11
article_number
71
pages
7 pages
Web of Science type
Article
Web of Science id
000303353800001
JCR category
TROPICAL MEDICINE
JCR impact factor
3.4 (2012)
JCR rank
2/21 (2012)
JCR quartile
1 (2012)
ISSN
1475-2875
DOI
10.1186/1475-2875-11-71
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
2130582
handle
http://hdl.handle.net/1854/LU-2130582
date created
2012-06-04 11:32:01
date last changed
2015-06-17 10:04:25
@article{2130582,
  abstract     = {Background: A prospective study aiming at assessing the effect of adding a third dose sulphadoxine-pyrimethamine (SP) to the standard two-dose intermittent preventive treatment for pregnant women was carried out in Hounde, Burkina Faso, between March 2006 and July 2008. Pregnant women were identified as earlier as possible during pregnancy through a network of home visitors, referred to the health facilities for inclusion and followed up until delivery. 
Methods: Study participants were enrolled at antenatal care (ANC) visits and randomized to receive either two or three doses of SP at the appropriate time. Women were visited daily and a blood slide was collected when there was fever (body temperature {\textrangle} 37.5 degrees C) or history of fever. Women were encouraged to attend ANC and deliver in the health centre, where the new-born was examined and weighed. The timing and frequency of malaria infection was analysed in relation to the risk of low birth weight, maternal anaemia and perinatal mortality. 
Results: Data on birth weight and haemoglobin were available for 1,034 women. The incidence of malaria infections was significantly lower in women having received three instead of two doses of SP. Occurrence of first malaria infection during the first or second trimester was associated with a higher risk of low birth weight: incidence rate ratios of 3.56 (p {\textlangle} 0.001) and 1.72 (p = 0.034), respectively. After adjusting for possible confounding factors, the risk remained significantly higher for the infection in the first trimester of pregnancy (adjusted incidence rate ratio = 2.07, p = 0.002). The risk of maternal anaemia and perinatal mortality was not associated with the timing of first malaria infection. 
Conclusion: Malaria infection during first trimester of pregnancy is associated to a higher risk of low birth weight. Women should be encouraged to use long-lasting insecticidal nets before and throughout their pregnancy.},
  articleno    = {71},
  author       = {Valea, Innocent and Tinto, Halidou and Drabo, Maxime and Huybregts, Lieven and Sorgho, Hermann and Ouedraogo, Jean-Bosco and Guiguemde, Robert and Van Geertruyden, Jean Pierre and Kolsteren, Patrick and D'Allessandro, Umberto},
  issn         = {1475-2875},
  journal      = {MALARIA JOURNAL},
  keyword      = {SULFADOXINE-PYRIMETHAMINE,IPT,INTERMITTENT PREVENTIVE TREATMENT,Pregnancy,Malaria infection,Sulphadoxine-pyrimethamine,First trimester,KOUPELA DISTRICT,AFRICA,BURDEN,PATHOGENESIS,IMMUNITY,PROGRAM,IMPACT},
  language     = {eng},
  pages        = {7},
  title        = {An analysis of timing and frequency of malaria infection during pregnancy in relation to the risk of low birth weight, anaemia and perinatal mortality in Burkina Faso},
  url          = {http://dx.doi.org/10.1186/1475-2875-11-71},
  volume       = {11},
  year         = {2012},
}

Chicago
Valea, Innocent, Halidou Tinto, Maxime Drabo, Lieven Huybregts, Hermann Sorgho, Jean-Bosco Ouedraogo, Robert Guiguemde, Jean Pierre Van Geertruyden, Patrick Kolsteren, and Umberto D’Allessandro. 2012. “An Analysis of Timing and Frequency of Malaria Infection During Pregnancy in Relation to the Risk of Low Birth Weight, Anaemia and Perinatal Mortality in Burkina Faso.” Malaria Journal 11.
APA
Valea, I., Tinto, H., Drabo, M., Huybregts, L., Sorgho, H., Ouedraogo, J.-B., Guiguemde, R., et al. (2012). An analysis of timing and frequency of malaria infection during pregnancy in relation to the risk of low birth weight, anaemia and perinatal mortality in Burkina Faso. MALARIA JOURNAL, 11.
Vancouver
1.
Valea I, Tinto H, Drabo M, Huybregts L, Sorgho H, Ouedraogo J-B, et al. An analysis of timing and frequency of malaria infection during pregnancy in relation to the risk of low birth weight, anaemia and perinatal mortality in Burkina Faso. MALARIA JOURNAL. 2012;11.
MLA
Valea, Innocent, Halidou Tinto, Maxime Drabo, et al. “An Analysis of Timing and Frequency of Malaria Infection During Pregnancy in Relation to the Risk of Low Birth Weight, Anaemia and Perinatal Mortality in Burkina Faso.” MALARIA JOURNAL 11 (2012): n. pag. Print.