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Maternal matrix metalloproteinase (MMP)-3 and 9 levels in preterm birth

Inge Tency UGent, Hans Verstraelen UGent, IVO KROES, Gabriële Holtappels UGent, Mario Vaneechoutte UGent, Rita Verhelst and Marleen Temmerman UGent (2010) European Society for Infectious Diseases in Obstetrics and Gynaecology, 7th European conference, Abstracts.
abstract
OBJECTIVE: MMPs may play a role in initiating labour and rupture of membranes. Therefore, we measured serum concentrations of MMP-3 and MMP-9 in women in preterm labour (group 1) as compared to women in term labour (group 2) and gestational age matched controls between 24-33 weeks not in labour (group 3). METHODS: Case-control study in singleton pregnancies. MMP-9 levels were measured in 27 women in group 1 and 3, and 26 women in group 2. MMP-3 levels were determined in 15 women in each group. Maternal serum MMP-3 and MMP-9 were measured by Luminex multianalyte profiling technology. A spike and recovery experiment was performed to validate the immunoassay for serum. RESULTS: Mean MMP-9 serum levels were significantly higher in preterm labour compared to term labour (3588.9 pg/ml vs. 1791.6 pg/ml; P < 0.001). MMP-9 levels were also higher in the preterm labour group as compared to gestational age matched controls (3588.9 pg/ml vs. 1628.4 pg/ml; P < 0.001). MMP-3 levels were not increased during preterm birth. The detection rate of MMP-3 in serum was lower than for MMP-9 (73.3% vs. 95%). CONCLUSION: MMP-9 was increased in patients with preterm labour, suggesting a role for MMP-9 in the process of preterm birth.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
unpublished
subject
in
European Society for Infectious Diseases in Obstetrics and Gynaecology, 7th European conference, Abstracts
conference name
7th European conference of European Society for Infectious Diseases in Obstetrics and Gynaecology
conference location
Trieste, Italy
conference start
2010-10-02
conference end
2010-10-05
language
English
UGent publication?
yes
classification
C3
id
2130058
handle
http://hdl.handle.net/1854/LU-2130058
date created
2012-06-03 22:35:33
date last changed
2016-12-19 15:36:40
@inproceedings{2130058,
  abstract     = {OBJECTIVE: MMPs may play a role in initiating labour and rupture of membranes. Therefore, we measured serum concentrations of MMP-3 and MMP-9 in women in preterm labour (group 1) as compared to women in term labour (group 2) and gestational age matched controls between 24-33 weeks not in labour (group 3).
METHODS: Case-control study in singleton pregnancies. MMP-9 levels were measured in 27 women in group 1 and 3, and 26 women in group 2. MMP-3 levels were determined in 15 women in each group. Maternal serum MMP-3 and MMP-9 were measured by Luminex multianalyte profiling technology. A spike and recovery experiment was performed to validate the immunoassay for serum.
RESULTS: Mean MMP-9 serum levels were significantly higher in preterm labour compared to term labour (3588.9 pg/ml vs. 1791.6 pg/ml; P {\textlangle} 0.001). MMP-9 levels were also higher in the preterm labour group as compared to gestational age matched controls (3588.9 pg/ml vs. 1628.4 pg/ml; P {\textlangle} 0.001). MMP-3 levels were not increased during preterm birth. The detection rate of MMP-3 in serum was lower than for MMP-9 (73.3\% vs. 95\%).
CONCLUSION: MMP-9 was increased in patients with preterm labour, suggesting a role for MMP-9 in the process of preterm birth.},
  author       = {Tency, Inge and Verstraelen, Hans and KROES, IVO and Holtappels, Gabri{\"e}le and Vaneechoutte, Mario and Verhelst, Rita and Temmerman, Marleen},
  booktitle    = {European Society for Infectious Diseases in Obstetrics and Gynaecology, 7th European conference, Abstracts},
  language     = {eng},
  location     = {Trieste, Italy},
  title        = {Maternal matrix metalloproteinase (MMP)-3 and 9 levels in preterm birth},
  year         = {2010},
}

Chicago
Tency, Inge, Hans Verstraelen, IVO KROES, Gabriële Holtappels, Mario Vaneechoutte, Rita Verhelst, and Marleen Temmerman. 2010. “Maternal Matrix Metalloproteinase (MMP)-3 and 9 Levels in Preterm Birth.” In European Society for Infectious Diseases in Obstetrics and Gynaecology, 7th European Conference, Abstracts.
APA
Tency, I., Verstraelen, H., KROES, I., Holtappels, G., Vaneechoutte, M., Verhelst, R., & Temmerman, M. (2010). Maternal matrix metalloproteinase (MMP)-3 and 9 levels in preterm birth. European Society for Infectious Diseases in Obstetrics and Gynaecology, 7th European conference, Abstracts. Presented at the 7th European conference of European Society for Infectious Diseases in Obstetrics and Gynaecology.
Vancouver
1.
Tency I, Verstraelen H, KROES I, Holtappels G, Vaneechoutte M, Verhelst R, et al. Maternal matrix metalloproteinase (MMP)-3 and 9 levels in preterm birth. European Society for Infectious Diseases in Obstetrics and Gynaecology, 7th European conference, Abstracts. 2010.
MLA
Tency, Inge, Hans Verstraelen, IVO KROES, et al. “Maternal Matrix Metalloproteinase (MMP)-3 and 9 Levels in Preterm Birth.” European Society for Infectious Diseases in Obstetrics and Gynaecology, 7th European Conference, Abstracts. 2010. Print.