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Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies

(2011) PLOS ONE. 6(10).
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Abstract
Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus. In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mainly observed in myeloid disorders; and unbalanced non-telomeric rearrangements (N = 39), mainly observed in lymphoid proliferations and frequently associated with a highly complex karyotype. The 1p36 rearrangement was isolated in 12 cases, mainly myeloid disorders. The breakpoints on 1p36 were more widely distributed than previously reported, but with identifiable rare breakpoint cluster regions, such as the TP73 locus. We also found novel partner loci on 1p36 for the known multi-partner genes HMGA2 and RUNX1. We precised the common terminal 1p36 deletion, which has been suggested to have an adverse prognosis, in B-cell lymphomas [follicular lymphomas and diffuse large B-cell lymphomas with t(14;18)(q32;q21) as well as follicular lymphomas without t(14;18)]. Intrachromosomal telomeric repetitive sequences were detected in at least half the cases of telomeric rearrangements. It is unclear how the latter rearrangements occurred and whether they represent oncogenic events or result from chromosomal instability during oncogenesis.
Keywords
TUMOR-SUPPRESSOR GENE, CHRONIC LYMPHOCYTIC-LEUKEMIA, NON-HODGKINS-LYMPHOMAS, IN-SITU HYBRIDIZATION, FOLLICULAR LYMPHOMA, COPY NUMBER, CHROMOSOMAL TRANSLOCATIONS, NEUROBLASTOMA, MYELODYSPLASTIC SYNDROME, CYTOGENETIC ANALYSIS

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MLA
Duhoux, François P et al. “Refinement of 1p36 Alterations Not Involving PRDM16 in Myeloid and Lymphoid Malignancies.” PLOS ONE 6.10 (2011): n. pag. Print.
APA
Duhoux, F. P., Ameye, G., Lambot, V., Herens, C., Lambert, F., Raynaud, S., Wlodarska, I., et al. (2011). Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies. PLOS ONE, 6(10).
Chicago author-date
Duhoux, François P, Geneviève Ameye, Virginie Lambot, Christian Herens, Frédéric Lambert, Sophie Raynaud, Iwona Wlodarska, et al. 2011. “Refinement of 1p36 Alterations Not Involving PRDM16 in Myeloid and Lymphoid Malignancies.” Plos One 6 (10).
Chicago author-date (all authors)
Duhoux, François P, Geneviève Ameye, Virginie Lambot, Christian Herens, Frédéric Lambert, Sophie Raynaud, Iwona Wlodarska, Lucienne Michaux, Catherine Roche-Lestienne, Elise Labis, Sylvie Taviaux, Elise Chapiro, Florence Nguyen-Khac, Stéphanie Struski, Sophie Dobbelstein, Nicole Dastugue, Eric Lippert, Franki Speleman, Nadine Van Roy, An De Weer, Katrina Rack, Pascaline Talmant, Steven Richebourg, Francine Mugneret, Isabelle Tigaud, Marie-Joëlle Mozziconacci, Sophy Laibe, Nathalie Nadal, Christine Terré, Jeanne-Marie Libouton, Anabelle Decottignies, Miikka Vikkula, and Hélène A Poirel. 2011. “Refinement of 1p36 Alterations Not Involving PRDM16 in Myeloid and Lymphoid Malignancies.” Plos One 6 (10).
Vancouver
1.
Duhoux FP, Ameye G, Lambot V, Herens C, Lambert F, Raynaud S, et al. Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies. PLOS ONE. 2011;6(10).
IEEE
[1]
F. P. Duhoux et al., “Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies,” PLOS ONE, vol. 6, no. 10, 2011.
@article{2127431,
  abstract     = {Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus. In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mainly observed in myeloid disorders; and unbalanced non-telomeric rearrangements (N = 39), mainly observed in lymphoid proliferations and frequently associated with a highly complex karyotype. The 1p36 rearrangement was isolated in 12 cases, mainly myeloid disorders. The breakpoints on 1p36 were more widely distributed than previously reported, but with identifiable rare breakpoint cluster regions, such as the TP73 locus. We also found novel partner loci on 1p36 for the known multi-partner genes HMGA2 and RUNX1. We precised the common terminal 1p36 deletion, which has been suggested to have an adverse prognosis, in B-cell lymphomas [follicular lymphomas and diffuse large B-cell lymphomas with t(14;18)(q32;q21) as well as follicular lymphomas without t(14;18)]. Intrachromosomal telomeric repetitive sequences were detected in at least half the cases of telomeric rearrangements. It is unclear how the latter rearrangements occurred and whether they represent oncogenic events or result from chromosomal instability during oncogenesis.},
  articleno    = {e26311},
  author       = {Duhoux, François P and Ameye, Geneviève and Lambot, Virginie and Herens, Christian and Lambert, Frédéric and Raynaud, Sophie and Wlodarska, Iwona and Michaux, Lucienne and Roche-Lestienne, Catherine and Labis, Elise and Taviaux, Sylvie and Chapiro, Elise and Nguyen-Khac, Florence and Struski, Stéphanie and Dobbelstein, Sophie and Dastugue, Nicole and Lippert, Eric and Speleman, Franki and Van Roy, Nadine and De Weer, An and Rack, Katrina and Talmant, Pascaline and Richebourg, Steven and Mugneret, Francine and Tigaud, Isabelle and Mozziconacci, Marie-Joëlle and Laibe, Sophy and Nadal, Nathalie and Terré, Christine and Libouton, Jeanne-Marie and Decottignies, Anabelle and Vikkula, Miikka and Poirel, Hélène A},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keywords     = {TUMOR-SUPPRESSOR GENE,CHRONIC LYMPHOCYTIC-LEUKEMIA,NON-HODGKINS-LYMPHOMAS,IN-SITU HYBRIDIZATION,FOLLICULAR LYMPHOMA,COPY NUMBER,CHROMOSOMAL TRANSLOCATIONS,NEUROBLASTOMA,MYELODYSPLASTIC SYNDROME,CYTOGENETIC ANALYSIS},
  language     = {eng},
  number       = {10},
  pages        = {9},
  title        = {Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies},
  url          = {http://dx.doi.org/10.1371/journal.pone.0026311},
  volume       = {6},
  year         = {2011},
}

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