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Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin

(2012) EMBO REPORTS. 13(4). p.355-362
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Abstract
The transcription factor Eomesodermin (Eomes) is involved in early embryonic patterning, but the range of cell fates that it controls as well as its mechanisms of action remain unclear. Here we show that transient expression of Eomes promotes cardiovascular fate during embryonic stem cell differentiation. Eomes also rapidly induces the expression of Mesp1, a key regulator of cardiovascular differentiation, and directly binds to regulatory sequences of Mesp1. Eomes effects are strikingly modulated by Activin signalling: high levels of Activin inhibit the promotion of cardiac mesoderm by Eomes, while they enhance Eomes-dependent endodermal specification. These results place Eomes upstream of the Mesp1-dependent programme of cardiogenesis, and at the intersection of mesodermal and endodermal specification, depending on the levels of Activin/Nodal signalling.
Keywords
Mesp1, Eomesodermin, Nodal/Activin, cardiac fate, embryonic stem cell, CARDIOVASCULAR PROGENITOR SPECIFICATION, EARLY MOUSE EMBRYO, DEFINITIVE ENDODERM, SMOOTH-MUSCLE, MESODERM FORMATION, PRIMITIVE STREAK, INDUCTION, GASTRULATION, COMMITMENT, ACTIVATION

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Citation

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MLA
van den Ameele, Jelle, Luca Tiberi, Antoine Bondue, et al. “Eomesodermin Induces Mesp1 Expression and Cardiac Differentiation from Embryonic Stem Cells in the Absence of Activin.” EMBO REPORTS 13.4 (2012): 355–362. Print.
APA
van den Ameele, J., Tiberi, L., Bondue, A., Paulissen, C., Herpoel, A., Iacovino, M., Kyba, M., et al. (2012). Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin. EMBO REPORTS, 13(4), 355–362.
Chicago author-date
van den Ameele, Jelle, Luca Tiberi, Antoine Bondue, Catherine Paulissen, Adèle Herpoel, Michelina Iacovino, Michael Kyba, Cédric Blanpain, and Pierre Vanderhaeghen. 2012. “Eomesodermin Induces Mesp1 Expression and Cardiac Differentiation from Embryonic Stem Cells in the Absence of Activin.” Embo Reports 13 (4): 355–362.
Chicago author-date (all authors)
van den Ameele, Jelle, Luca Tiberi, Antoine Bondue, Catherine Paulissen, Adèle Herpoel, Michelina Iacovino, Michael Kyba, Cédric Blanpain, and Pierre Vanderhaeghen. 2012. “Eomesodermin Induces Mesp1 Expression and Cardiac Differentiation from Embryonic Stem Cells in the Absence of Activin.” Embo Reports 13 (4): 355–362.
Vancouver
1.
van den Ameele J, Tiberi L, Bondue A, Paulissen C, Herpoel A, Iacovino M, et al. Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin. EMBO REPORTS. 2012;13(4):355–62.
IEEE
[1]
J. van den Ameele et al., “Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin,” EMBO REPORTS, vol. 13, no. 4, pp. 355–362, 2012.
@article{2125974,
  abstract     = {The transcription factor Eomesodermin (Eomes) is involved in early embryonic patterning, but the range of cell fates that it controls as well as its mechanisms of action remain unclear. Here we show that transient expression of Eomes promotes cardiovascular fate during embryonic stem cell differentiation. Eomes also rapidly induces the expression of Mesp1, a key regulator of cardiovascular differentiation, and directly binds to regulatory sequences of Mesp1. Eomes effects are strikingly modulated by Activin signalling: high levels of Activin inhibit the promotion of cardiac mesoderm by Eomes, while they enhance Eomes-dependent endodermal specification. These results place Eomes upstream of the Mesp1-dependent programme of cardiogenesis, and at the intersection of mesodermal and endodermal specification, depending on the levels of Activin/Nodal signalling.},
  author       = {van den Ameele, Jelle and Tiberi, Luca and Bondue, Antoine and Paulissen, Catherine and Herpoel, Adèle and Iacovino, Michelina and Kyba, Michael and Blanpain, Cédric and Vanderhaeghen, Pierre},
  issn         = {1469-221X},
  journal      = {EMBO REPORTS},
  keywords     = {Mesp1,Eomesodermin,Nodal/Activin,cardiac fate,embryonic stem cell,CARDIOVASCULAR PROGENITOR SPECIFICATION,EARLY MOUSE EMBRYO,DEFINITIVE ENDODERM,SMOOTH-MUSCLE,MESODERM FORMATION,PRIMITIVE STREAK,INDUCTION,GASTRULATION,COMMITMENT,ACTIVATION},
  language     = {eng},
  number       = {4},
  pages        = {355--362},
  title        = {Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin},
  url          = {http://dx.doi.org/10.1038/embor.2012.23},
  volume       = {13},
  year         = {2012},
}

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