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Sex hormone-binding globulin at the crossroad of body composition, somatotropic axis and insulin/glucose homeostasis in young healthy men

Griet Vanbillemont UGent, Bruno Lapauw UGent, Hélène Denaeyer, GREET ROEF, Jean Kaufman UGent and Youri Taes (2012) CLINICAL ENDOCRINOLOGY. 76(1). p.111-118
abstract
OBJECTIVES:Sex hormone-binding globulin (SHBG) modulates the bioavailability of sex steroids at tissue level. Genetic, hormonal and lifestyle-related factors determine the SHBG levels, and low SHBG levels are a known risk factor for the development of the metabolic syndrome, diabetes and cardiovascular diseases. We investigated to what extent different determinants contribute to the variation in SHBG levels in healthy young men. DESIGN AND PATIENTS: Healthy male siblings (n = 677) aged 25-45 year were recruited in a cross-sectional, population-based study. MEASUREMENTS: Lean and fat mass were measured using dual-energy X-ray absorptiometry (DXA), and immunoassays were used to determine the serum hormonal levels. Additional information about smoking and physical activity was obtained using questionnaires. Carriers of two SHBG polymorphisms, the Asp327Asn polymorphism and the (TAAAA)(n) repeat polymorphism, were identified. RESULTS: Weight, BMI, whole body fat mass and truncal fat mass were negatively associated with SHBG levels. Body composition characteristics did not differ between SHBG genotype groups, indicating that body composition controls SHBG levels rather than the other way around. The associations may be mediated by adipokines because leptin and adiponectin were, respectively, inversely and positively associated with SHBG levels. Insulin and glucose were negatively associated with SHBG levels, as well as IGF-1 and IGF-BP3, while no associations were found with free thyroid hormone status. CONCLUSIONS: In conclusion, we found that fat mass, insulin and IGF-1 levels are important negative determinants of SHBG levels in young healthy men. The association with fat mass could be mediated by the effects of adiponectin and/or leptin on SHBG synthesis.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ELDERLY-MEN, METABOLIC SYNDROME, CARDIOVASCULAR RISK, SERUM ADIPONECTIN, FREE TESTOSTERONE, MALE SIBLINGS, CELL LINE, INSULIN, OBESITY, SHBG
journal title
CLINICAL ENDOCRINOLOGY
Clin. Endocrinol.
volume
76
issue
1
pages
111 - 118
Web of Science type
Article
Web of Science id
000297739700017
JCR category
ENDOCRINOLOGY & METABOLISM
JCR impact factor
3.396 (2012)
JCR rank
46/121 (2012)
JCR quartile
2 (2012)
ISSN
0300-0664
DOI
10.1111/j.1365-2265.2011.04155.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2125249
handle
http://hdl.handle.net/1854/LU-2125249
date created
2012-05-31 14:51:35
date last changed
2016-12-19 15:42:55
@article{2125249,
  abstract     = {OBJECTIVES:Sex hormone-binding globulin (SHBG) modulates the bioavailability of sex steroids at tissue level. Genetic, hormonal and lifestyle-related factors determine the SHBG levels, and low SHBG levels are a known risk factor for the development of the metabolic syndrome, diabetes and cardiovascular diseases. We investigated to what extent different determinants contribute to the variation in SHBG levels in healthy young men.
DESIGN AND PATIENTS: Healthy male siblings (n = 677) aged 25-45 year were recruited in a cross-sectional, population-based study.
MEASUREMENTS: Lean and fat mass were measured using dual-energy X-ray absorptiometry (DXA), and immunoassays were used to determine the serum hormonal levels. Additional information about smoking and physical activity was obtained using questionnaires. Carriers of two SHBG polymorphisms, the Asp327Asn polymorphism and the (TAAAA)(n) repeat polymorphism, were identified.
RESULTS: Weight, BMI, whole body fat mass and truncal fat mass were negatively associated with SHBG levels. Body composition characteristics did not differ between SHBG genotype groups, indicating that body composition controls SHBG levels rather than the other way around. The associations may be mediated by adipokines because leptin and adiponectin were, respectively, inversely and positively associated with SHBG levels. Insulin and glucose were negatively associated with SHBG levels, as well as IGF-1 and IGF-BP3, while no associations were found with free thyroid hormone status.
CONCLUSIONS: In conclusion, we found that fat mass, insulin and IGF-1 levels are important negative determinants of SHBG levels in young healthy men. The association with fat mass could be mediated by the effects of adiponectin and/or leptin on SHBG synthesis.},
  author       = {Vanbillemont, Griet and Lapauw, Bruno and Denaeyer, H{\'e}l{\`e}ne and ROEF, GREET and Kaufman, Jean and Taes, Youri},
  issn         = {0300-0664},
  journal      = {CLINICAL ENDOCRINOLOGY},
  keyword      = {ELDERLY-MEN,METABOLIC SYNDROME,CARDIOVASCULAR RISK,SERUM ADIPONECTIN,FREE TESTOSTERONE,MALE SIBLINGS,CELL LINE,INSULIN,OBESITY,SHBG},
  language     = {eng},
  number       = {1},
  pages        = {111--118},
  title        = {Sex hormone-binding globulin at the crossroad of body composition, somatotropic axis and insulin/glucose homeostasis in young healthy men},
  url          = {http://dx.doi.org/10.1111/j.1365-2265.2011.04155.x},
  volume       = {76},
  year         = {2012},
}

Chicago
Vanbillemont, Griet, Bruno Lapauw, Hélène Denaeyer, GREET ROEF, Jean Kaufman, and Youri Taes. 2012. “Sex Hormone-binding Globulin at the Crossroad of Body Composition, Somatotropic Axis and Insulin/glucose Homeostasis in Young Healthy Men.” Clinical Endocrinology 76 (1): 111–118.
APA
Vanbillemont, G., Lapauw, B., Denaeyer, H., ROEF, G., Kaufman, J., & Taes, Y. (2012). Sex hormone-binding globulin at the crossroad of body composition, somatotropic axis and insulin/glucose homeostasis in young healthy men. CLINICAL ENDOCRINOLOGY, 76(1), 111–118.
Vancouver
1.
Vanbillemont G, Lapauw B, Denaeyer H, ROEF G, Kaufman J, Taes Y. Sex hormone-binding globulin at the crossroad of body composition, somatotropic axis and insulin/glucose homeostasis in young healthy men. CLINICAL ENDOCRINOLOGY. 2012;76(1):111–8.
MLA
Vanbillemont, Griet, Bruno Lapauw, Hélène Denaeyer, et al. “Sex Hormone-binding Globulin at the Crossroad of Body Composition, Somatotropic Axis and Insulin/glucose Homeostasis in Young Healthy Men.” CLINICAL ENDOCRINOLOGY 76.1 (2012): 111–118. Print.