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Coll2-1, Coll2-1NO2 and myeloperoxidase concentrations in the synovial fluid of equine tarsocrural joints affected with osteochondrosis

Denis R Verwilghen, Ann Martens UGent, Evita Busschers, Thierry Franck, Michelle Deberg, Yves Henrotin, Laurent Vanderheyden and Didier Serteyn (2011) VETERINARY RESEARCH COMMUNICATIONS. 35(7). p.401-408
abstract
The measurement of biomarkers that reflect cartilage breakdown is a powerful tool for investigating joint damage caused by disease or injury. Particularly in cases of osteochondrosis, synovial concentrations of these biomarkers may reveal the presence of osteoarthritic changes. Coll2-1, Coll2-1 NO2 and myeloperoxidase have recently been introduced in equine osteoarticular research but comparison between the concentrations of these markers in OCD affected and healthy joints has not been made. Therefore, this study aimed at reporting the synovial concentrations of these biomarkers in joints affected with osteochondral fragments in the tarsocrural joint compared to unaffected joints. Myeloperoxidase and Coll2-1NO(2) revealed to have similar levels between affected joints and controls. However, in contrast to previous studies using C2C the present study demonstrated that synovial levels of Coll2-1 were significantly elevated in tarsocrural joints affected with osteochondrosis. Thus, Coll2-1 may be an earlier marker of cartilage degeneration than other cartilage degradation markers that have been previously used in equine medicine.
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author
organization
alternative title
Coll2-1, Coll2-1NO(2) and myeloperoxidase concentrations in the synovial fluid of equine tarsocrural joints affected with osteochondrosis
year
type
journalArticle (original)
publication status
published
subject
keyword
Coll2-1, NITRIC-OXIDE, Horse, Biomarkers, Osteochondrosis, II-COLLAGEN, COLLAGEN-DERIVED PEPTIDE, Collagen degradation, MPO, HUMAN CHONDROCYTES, MARKERS, BIOMARKERS, IN-VIVO, OSTEOARTHRITIS, CARTILAGE DEGRADATION, NITRATED FORM
journal title
VETERINARY RESEARCH COMMUNICATIONS
Vet. Res. Commun.
volume
35
issue
7
pages
401 - 408
Web of Science type
Article
Web of Science id
000294497700001
JCR category
VETERINARY SCIENCES
JCR impact factor
0.822 (2011)
JCR rank
70/141 (2011)
JCR quartile
2 (2011)
ISSN
0165-7380
DOI
10.1007/s11259-011-9487-5
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2124823
handle
http://hdl.handle.net/1854/LU-2124823
date created
2012-05-31 12:53:02
date last changed
2012-05-31 15:46:20
@article{2124823,
  abstract     = {The measurement of biomarkers that reflect cartilage breakdown is a powerful tool for investigating joint damage caused by disease or injury. Particularly in cases of osteochondrosis, synovial concentrations of these biomarkers may reveal the presence of osteoarthritic changes. Coll2-1, Coll2-1 NO2 and myeloperoxidase have recently been introduced in equine osteoarticular research but comparison between the concentrations of these markers in OCD affected and healthy joints has not been made. Therefore, this study aimed at reporting the synovial concentrations of these biomarkers in joints affected with osteochondral fragments in the tarsocrural joint compared to unaffected joints. Myeloperoxidase and Coll2-1NO(2) revealed to have similar levels between affected joints and controls. However, in contrast to previous studies using C2C the present study demonstrated that synovial levels of Coll2-1 were significantly elevated in tarsocrural joints affected with osteochondrosis. Thus, Coll2-1 may be an earlier marker of cartilage degeneration than other cartilage degradation markers that have been previously used in equine medicine.},
  author       = {Verwilghen, Denis R and Martens, Ann and Busschers, Evita and Franck, Thierry and Deberg, Michelle and Henrotin, Yves and Vanderheyden, Laurent and Serteyn, Didier},
  issn         = {0165-7380},
  journal      = {VETERINARY RESEARCH COMMUNICATIONS},
  keyword      = {Coll2-1,NITRIC-OXIDE,Horse,Biomarkers,Osteochondrosis,II-COLLAGEN,COLLAGEN-DERIVED PEPTIDE,Collagen degradation,MPO,HUMAN CHONDROCYTES,MARKERS,BIOMARKERS,IN-VIVO,OSTEOARTHRITIS,CARTILAGE DEGRADATION,NITRATED FORM},
  language     = {eng},
  number       = {7},
  pages        = {401--408},
  title        = {Coll2-1, Coll2-1NO2 and myeloperoxidase concentrations in the synovial fluid of equine tarsocrural joints affected with osteochondrosis},
  url          = {http://dx.doi.org/10.1007/s11259-011-9487-5},
  volume       = {35},
  year         = {2011},
}

Chicago
Verwilghen, Denis R, Ann Martens, Evita Busschers, Thierry Franck, Michelle Deberg, Yves Henrotin, Laurent Vanderheyden, and Didier Serteyn. 2011. “Coll2-1, Coll2-1NO2 and Myeloperoxidase Concentrations in the Synovial Fluid of Equine Tarsocrural Joints Affected with Osteochondrosis.” Veterinary Research Communications 35 (7): 401–408.
APA
Verwilghen, D. R., Martens, A., Busschers, E., Franck, T., Deberg, M., Henrotin, Y., Vanderheyden, L., et al. (2011). Coll2-1, Coll2-1NO2 and myeloperoxidase concentrations in the synovial fluid of equine tarsocrural joints affected with osteochondrosis. VETERINARY RESEARCH COMMUNICATIONS, 35(7), 401–408.
Vancouver
1.
Verwilghen DR, Martens A, Busschers E, Franck T, Deberg M, Henrotin Y, et al. Coll2-1, Coll2-1NO2 and myeloperoxidase concentrations in the synovial fluid of equine tarsocrural joints affected with osteochondrosis. VETERINARY RESEARCH COMMUNICATIONS. 2011;35(7):401–8.
MLA
Verwilghen, Denis R, Ann Martens, Evita Busschers, et al. “Coll2-1, Coll2-1NO2 and Myeloperoxidase Concentrations in the Synovial Fluid of Equine Tarsocrural Joints Affected with Osteochondrosis.” VETERINARY RESEARCH COMMUNICATIONS 35.7 (2011): 401–408. Print.