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The transition of acute to chronic bowel inflammation in spondyloarthritis

Liesbet Van Praet UGent, PEGGY JACQUES UGent, Filip Van den Bosch UGent and Dirk Elewaut UGent (2012) NATURE REVIEWS RHEUMATOLOGY. 8(5). p.288-295
abstract
That gut and joint inflammation are linked in spondyloarthritis (SpA) has been recognized for almost three decades. Intriguingly, microscopic gut inflammation, which occurs frequently in patients with SpA, is an important risk factor for clinically overt Crohn's disease and ankylosing spondylitis. This Review describes current insights into the underlying mechanisms that lead to chronic gut inflammation in patients with SpA. We propose that the development of chronic bowel inflammation in these individuals occurs through a transition phase, in which inflammation evolves from an acute into a chronic state. Our transition model implies that different cell types are involved at different stages during disease progression, with stromal cells having an important role in chronicity. In addition, deficient regulatory feedback mechanisms or genetically determined alterations in antigen presentation, endoplasmic reticulum stress, autophagy or cytokine signaling might also favor a transition from self-limiting acute inflammation to chronic inflammation. We anticipate that this transition phase might be an important window for therapeutic intervention.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
SUSCEPTIBILITY LOCI, RHEUMATOID-ARTHRITIS, CROHNS-DISEASE, GUT INFLAMMATION, ANKYLOSING-SPONDYLITIS, PLACEBO-CONTROLLED TRIAL, SUBCLINICAL INTESTINAL INFLAMMATION, GENOME-WIDE ASSOCIATION, INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY, REGULATORY T-CELLS
journal title
NATURE REVIEWS RHEUMATOLOGY
Nat. Rev. Rheumatol.
volume
8
issue
5
pages
288 - 295
Web of Science type
Review
Web of Science id
000303610700007
JCR category
RHEUMATOLOGY
JCR impact factor
9.745 (2012)
JCR rank
1/29 (2012)
JCR quartile
1 (2012)
ISSN
1759-4790
DOI
10.1038/nrrheum.2012.42
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2124492
handle
http://hdl.handle.net/1854/LU-2124492
date created
2012-05-31 11:31:39
date last changed
2013-05-16 13:14:19
@article{2124492,
  abstract     = {That gut and joint inflammation are linked in spondyloarthritis (SpA) has been recognized for almost three decades. Intriguingly, microscopic gut inflammation, which occurs frequently in patients with SpA, is an important risk factor for clinically overt Crohn's disease and ankylosing spondylitis. This Review describes current insights into the underlying mechanisms that lead to chronic gut inflammation in patients with SpA. We propose that the development of chronic bowel inflammation in these individuals occurs through a transition phase, in which inflammation evolves from an acute into a chronic state. Our transition model implies that different cell types are involved at different stages during disease progression, with stromal cells having an important role in chronicity. In addition, deficient regulatory feedback mechanisms or genetically determined alterations in antigen presentation, endoplasmic reticulum stress, autophagy or cytokine signaling might also favor a transition from self-limiting acute inflammation to chronic inflammation. We anticipate that this transition phase might be an important window for therapeutic intervention.},
  author       = {Van Praet, Liesbet and JACQUES, PEGGY and Van den Bosch, Filip and Elewaut, Dirk},
  issn         = {1759-4790},
  journal      = {NATURE REVIEWS RHEUMATOLOGY},
  keyword      = {SUSCEPTIBILITY LOCI,RHEUMATOID-ARTHRITIS,CROHNS-DISEASE,GUT INFLAMMATION,ANKYLOSING-SPONDYLITIS,PLACEBO-CONTROLLED TRIAL,SUBCLINICAL INTESTINAL INFLAMMATION,GENOME-WIDE ASSOCIATION,INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY,REGULATORY T-CELLS},
  language     = {eng},
  number       = {5},
  pages        = {288--295},
  title        = {The transition of acute to chronic bowel inflammation in spondyloarthritis},
  url          = {http://dx.doi.org/10.1038/nrrheum.2012.42},
  volume       = {8},
  year         = {2012},
}

Chicago
Van Praet, Liesbet, Peggy Jacques, Filip Van den Bosch, and Dirk Elewaut. 2012. “The Transition of Acute to Chronic Bowel Inflammation in Spondyloarthritis.” Nature Reviews Rheumatology 8 (5): 288–295.
APA
Van Praet, L., Jacques, P., Van den Bosch, F., & Elewaut, D. (2012). The transition of acute to chronic bowel inflammation in spondyloarthritis. NATURE REVIEWS RHEUMATOLOGY, 8(5), 288–295.
Vancouver
1.
Van Praet L, Jacques P, Van den Bosch F, Elewaut D. The transition of acute to chronic bowel inflammation in spondyloarthritis. NATURE REVIEWS RHEUMATOLOGY. 2012;8(5):288–95.
MLA
Van Praet, Liesbet, Peggy Jacques, Filip Van den Bosch, et al. “The Transition of Acute to Chronic Bowel Inflammation in Spondyloarthritis.” NATURE REVIEWS RHEUMATOLOGY 8.5 (2012): 288–295. Print.