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The transition of acute to chronic bowel inflammation in spondyloarthritis

(2012) NATURE REVIEWS RHEUMATOLOGY. 8(5). p.288-295
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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
That gut and joint inflammation are linked in spondyloarthritis (SpA) has been recognized for almost three decades. Intriguingly, microscopic gut inflammation, which occurs frequently in patients with SpA, is an important risk factor for clinically overt Crohn's disease and ankylosing spondylitis. This Review describes current insights into the underlying mechanisms that lead to chronic gut inflammation in patients with SpA. We propose that the development of chronic bowel inflammation in these individuals occurs through a transition phase, in which inflammation evolves from an acute into a chronic state. Our transition model implies that different cell types are involved at different stages during disease progression, with stromal cells having an important role in chronicity. In addition, deficient regulatory feedback mechanisms or genetically determined alterations in antigen presentation, endoplasmic reticulum stress, autophagy or cytokine signaling might also favor a transition from self-limiting acute inflammation to chronic inflammation. We anticipate that this transition phase might be an important window for therapeutic intervention.
Keywords
SUSCEPTIBILITY LOCI, RHEUMATOID-ARTHRITIS, CROHNS-DISEASE, GUT INFLAMMATION, ANKYLOSING-SPONDYLITIS, PLACEBO-CONTROLLED TRIAL, SUBCLINICAL INTESTINAL INFLAMMATION, GENOME-WIDE ASSOCIATION, INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY, REGULATORY T-CELLS

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Chicago
Van Praet, Liesbet, Peggy Jacques, Filip Van den Bosch, and Dirk Elewaut. 2012. “The Transition of Acute to Chronic Bowel Inflammation in Spondyloarthritis.” Nature Reviews Rheumatology 8 (5): 288–295.
APA
Van Praet, L., Jacques, P., Van den Bosch, F., & Elewaut, D. (2012). The transition of acute to chronic bowel inflammation in spondyloarthritis. NATURE REVIEWS RHEUMATOLOGY, 8(5), 288–295.
Vancouver
1.
Van Praet L, Jacques P, Van den Bosch F, Elewaut D. The transition of acute to chronic bowel inflammation in spondyloarthritis. NATURE REVIEWS RHEUMATOLOGY. 2012;8(5):288–95.
MLA
Van Praet, Liesbet, Peggy Jacques, Filip Van den Bosch, et al. “The Transition of Acute to Chronic Bowel Inflammation in Spondyloarthritis.” NATURE REVIEWS RHEUMATOLOGY 8.5 (2012): 288–295. Print.
@article{2124492,
  abstract     = {That gut and joint inflammation are linked in spondyloarthritis (SpA) has been recognized for almost three decades. Intriguingly, microscopic gut inflammation, which occurs frequently in patients with SpA, is an important risk factor for clinically overt Crohn's disease and ankylosing spondylitis. This Review describes current insights into the underlying mechanisms that lead to chronic gut inflammation in patients with SpA. We propose that the development of chronic bowel inflammation in these individuals occurs through a transition phase, in which inflammation evolves from an acute into a chronic state. Our transition model implies that different cell types are involved at different stages during disease progression, with stromal cells having an important role in chronicity. In addition, deficient regulatory feedback mechanisms or genetically determined alterations in antigen presentation, endoplasmic reticulum stress, autophagy or cytokine signaling might also favor a transition from self-limiting acute inflammation to chronic inflammation. We anticipate that this transition phase might be an important window for therapeutic intervention.},
  author       = {Van Praet, Liesbet and Jacques, Peggy and Van den Bosch, Filip and Elewaut, Dirk},
  issn         = {1759-4790},
  journal      = {NATURE REVIEWS RHEUMATOLOGY},
  keyword      = {SUSCEPTIBILITY LOCI,RHEUMATOID-ARTHRITIS,CROHNS-DISEASE,GUT INFLAMMATION,ANKYLOSING-SPONDYLITIS,PLACEBO-CONTROLLED TRIAL,SUBCLINICAL INTESTINAL INFLAMMATION,GENOME-WIDE ASSOCIATION,INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY,REGULATORY T-CELLS},
  language     = {eng},
  number       = {5},
  pages        = {288--295},
  title        = {The transition of acute to chronic bowel inflammation in spondyloarthritis},
  url          = {http://dx.doi.org/10.1038/nrrheum.2012.42},
  volume       = {8},
  year         = {2012},
}

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