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The airway epithelium in asthma

Bart Lambrecht UGent and Hamida Hammad UGent (2012) NATURE MEDICINE. 18(5). p.684-692
abstract
Asthma is a T lymphocyte-controlled disease of the airway wall caused by inflammation, overproduction of mucus and airway wall remodeling leading to bronchial hyperreactivity and airway obstruction. The airway epithelium is considered an essential controller of inflammatory, immune and regenerative responses to allergens, viruses and environmental pollutants that contribute to asthma pathogenesis. Epithelial cells express pattern recognition receptors that detect environmental stimuli and secrete endogenous danger signals, thereby activating dendritic cells and bridging innate and adaptive immunity. Improved understanding of the epithelium's function in maintaining the integrity of the airways and its dysfunction in asthma has provided important mechanistic insight into how asthma is initiated and perpetuated and could provide a framework by which to select new therapeutic strategies that prevent exacerbations and alter the natural course of the disease.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
HOUSE-DUST MITE, RESPIRATORY SYNCYTIAL VIRUS, THYMIC STROMAL LYMPHOPOIETIN, EPIDERMAL-GROWTH-FACTOR, PROTEASE-ACTIVATED RECEPTOR-2, INFLAMMATORY DENDRITIC CELLS, ALLERGIC LUNG INFLAMMATION, INNATE IMMUNE-RESPONSES, FACTOR-KAPPA-B, IN-VIVO
journal title
NATURE MEDICINE
Nat. Med.
volume
18
issue
5
pages
684 - 692
Web of Science type
Review
Web of Science id
000303763500036
JCR category
MEDICINE, RESEARCH & EXPERIMENTAL
JCR impact factor
22.864 (2012)
JCR rank
1/119 (2012)
JCR quartile
1 (2012)
ISSN
1078-8956
DOI
10.1038/nm.2737
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2124328
handle
http://hdl.handle.net/1854/LU-2124328
date created
2012-05-31 10:53:10
date last changed
2014-05-12 11:00:13
@article{2124328,
  abstract     = {Asthma is a T lymphocyte-controlled disease of the airway wall caused by inflammation, overproduction of mucus and airway wall remodeling leading to bronchial hyperreactivity and airway obstruction. The airway epithelium is considered an essential controller of inflammatory, immune and regenerative responses to allergens, viruses and environmental pollutants that contribute to asthma pathogenesis. Epithelial cells express pattern recognition receptors that detect environmental stimuli and secrete endogenous danger signals, thereby activating dendritic cells and bridging innate and adaptive immunity. Improved understanding of the epithelium's function in maintaining the integrity of the airways and its dysfunction in asthma has provided important mechanistic insight into how asthma is initiated and perpetuated and could provide a framework by which to select new therapeutic strategies that prevent exacerbations and alter the natural course of the disease.},
  author       = {Lambrecht, Bart and Hammad, Hamida},
  issn         = {1078-8956},
  journal      = {NATURE MEDICINE},
  keyword      = {HOUSE-DUST MITE,RESPIRATORY SYNCYTIAL VIRUS,THYMIC STROMAL LYMPHOPOIETIN,EPIDERMAL-GROWTH-FACTOR,PROTEASE-ACTIVATED RECEPTOR-2,INFLAMMATORY DENDRITIC CELLS,ALLERGIC LUNG INFLAMMATION,INNATE IMMUNE-RESPONSES,FACTOR-KAPPA-B,IN-VIVO},
  language     = {eng},
  number       = {5},
  pages        = {684--692},
  title        = {The airway epithelium in asthma},
  url          = {http://dx.doi.org/10.1038/nm.2737},
  volume       = {18},
  year         = {2012},
}

Chicago
Lambrecht, Bart, and Hamida Hammad. 2012. “The Airway Epithelium in Asthma.” Nature Medicine 18 (5): 684–692.
APA
Lambrecht, B., & Hammad, H. (2012). The airway epithelium in asthma. NATURE MEDICINE, 18(5), 684–692.
Vancouver
1.
Lambrecht B, Hammad H. The airway epithelium in asthma. NATURE MEDICINE. 2012;18(5):684–92.
MLA
Lambrecht, Bart, and Hamida Hammad. “The Airway Epithelium in Asthma.” NATURE MEDICINE 18.5 (2012): 684–692. Print.