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The airway epithelium in asthma

Bart Lambrecht (UGent) and Hamida Hammad (UGent)
(2012) NATURE MEDICINE. 18(5). p.684-692
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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
Asthma is a T lymphocyte-controlled disease of the airway wall caused by inflammation, overproduction of mucus and airway wall remodeling leading to bronchial hyperreactivity and airway obstruction. The airway epithelium is considered an essential controller of inflammatory, immune and regenerative responses to allergens, viruses and environmental pollutants that contribute to asthma pathogenesis. Epithelial cells express pattern recognition receptors that detect environmental stimuli and secrete endogenous danger signals, thereby activating dendritic cells and bridging innate and adaptive immunity. Improved understanding of the epithelium's function in maintaining the integrity of the airways and its dysfunction in asthma has provided important mechanistic insight into how asthma is initiated and perpetuated and could provide a framework by which to select new therapeutic strategies that prevent exacerbations and alter the natural course of the disease.
Keywords
HOUSE-DUST MITE, RESPIRATORY SYNCYTIAL VIRUS, THYMIC STROMAL LYMPHOPOIETIN, EPIDERMAL-GROWTH-FACTOR, PROTEASE-ACTIVATED RECEPTOR-2, INFLAMMATORY DENDRITIC CELLS, ALLERGIC LUNG INFLAMMATION, INNATE IMMUNE-RESPONSES, FACTOR-KAPPA-B, IN-VIVO

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Citation

Please use this url to cite or link to this publication:

Chicago
Lambrecht, Bart, and Hamida Hammad. 2012. “The Airway Epithelium in Asthma.” Nature Medicine 18 (5): 684–692.
APA
Lambrecht, Bart, & Hammad, H. (2012). The airway epithelium in asthma. NATURE MEDICINE, 18(5), 684–692.
Vancouver
1.
Lambrecht B, Hammad H. The airway epithelium in asthma. NATURE MEDICINE. 2012;18(5):684–92.
MLA
Lambrecht, Bart, and Hamida Hammad. “The Airway Epithelium in Asthma.” NATURE MEDICINE 18.5 (2012): 684–692. Print.
@article{2124328,
  abstract     = {Asthma is a T lymphocyte-controlled disease of the airway wall caused by inflammation, overproduction of mucus and airway wall remodeling leading to bronchial hyperreactivity and airway obstruction. The airway epithelium is considered an essential controller of inflammatory, immune and regenerative responses to allergens, viruses and environmental pollutants that contribute to asthma pathogenesis. Epithelial cells express pattern recognition receptors that detect environmental stimuli and secrete endogenous danger signals, thereby activating dendritic cells and bridging innate and adaptive immunity. Improved understanding of the epithelium's function in maintaining the integrity of the airways and its dysfunction in asthma has provided important mechanistic insight into how asthma is initiated and perpetuated and could provide a framework by which to select new therapeutic strategies that prevent exacerbations and alter the natural course of the disease.},
  author       = {Lambrecht, Bart and Hammad, Hamida},
  issn         = {1078-8956},
  journal      = {NATURE MEDICINE},
  keyword      = {HOUSE-DUST MITE,RESPIRATORY SYNCYTIAL VIRUS,THYMIC STROMAL LYMPHOPOIETIN,EPIDERMAL-GROWTH-FACTOR,PROTEASE-ACTIVATED RECEPTOR-2,INFLAMMATORY DENDRITIC CELLS,ALLERGIC LUNG INFLAMMATION,INNATE IMMUNE-RESPONSES,FACTOR-KAPPA-B,IN-VIVO},
  language     = {eng},
  number       = {5},
  pages        = {684--692},
  title        = {The airway epithelium in asthma},
  url          = {http://dx.doi.org/10.1038/nm.2737},
  volume       = {18},
  year         = {2012},
}

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