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Prosthetic valve endocarditis caused by Bordetella holmesii, an Acinetobacter lookalike

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Abstract
We report a case of fulminant endocarditis on a prosthetic homograft aortic valve caused by Bordetella holmesii, which was successfully managed by surgical valve replacement and antibiotic treatment. B. holmesii, a strictly aerobic, small, Gram-negative coccobacillus, has been implicated as an infrequent cause of a pertussis-like syndrome and other respiratory illnesses. However, B. holmesii is also a rare cause of septicaemia and infective endocarditis, mostly in immunocompromised patients. To our knowledge, this is the first report of B. holmesii endocarditis on a prosthetic aortic valve. Routine laboratory testing initially misidentified the strain as Acinetobacter sp. Correct identification was achieved by 16S rRNA gene and outer-membrane protein A (ompA) gene sequencing. Interestingly, matrix-assisted laser desorption/ionization timeof-flight mass spectrometry also produced an accurate species-level identification. Subsequent susceptibility testing and review of the literature revealed ceftazidime, cefepime, carbapenems, aminoglycosides, fluoroquinolones, piperacillin/tazobactam, tigecycline and colistin as possible candidates to treat infections caused by B. holmesii.
Keywords
endocarditis, Bordetella holmesii

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Citation

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Chicago
Jonckheere, Stijn, Thierry De Baere, Pascal Schroeyers, Oriane Soetens, Annelies De Bel, and Ignace Surmont. 2012. “Prosthetic Valve Endocarditis Caused by Bordetella Holmesii, an Acinetobacter Lookalike.” Journal of Medical Microbiology 61 (6): 874–877.
APA
Jonckheere, Stijn, De Baere, T., Schroeyers, P., Soetens, O., De Bel, A., & Surmont, I. (2012). Prosthetic valve endocarditis caused by Bordetella holmesii, an Acinetobacter lookalike. JOURNAL OF MEDICAL MICROBIOLOGY, 61(6), 874–877.
Vancouver
1.
Jonckheere S, De Baere T, Schroeyers P, Soetens O, De Bel A, Surmont I. Prosthetic valve endocarditis caused by Bordetella holmesii, an Acinetobacter lookalike. JOURNAL OF MEDICAL MICROBIOLOGY. 2012;61(6):874–7.
MLA
Jonckheere, Stijn, Thierry De Baere, Pascal Schroeyers, et al. “Prosthetic Valve Endocarditis Caused by Bordetella Holmesii, an Acinetobacter Lookalike.” JOURNAL OF MEDICAL MICROBIOLOGY 61.6 (2012): 874–877. Print.
@article{2123541,
  abstract     = {We report a case of fulminant endocarditis on a prosthetic homograft aortic valve caused by Bordetella holmesii, which was successfully managed by surgical valve replacement and antibiotic treatment. B. holmesii, a strictly aerobic, small, Gram-negative coccobacillus, has been implicated as an infrequent cause of a pertussis-like syndrome and other respiratory illnesses. However, B. holmesii is also a rare cause of septicaemia and infective endocarditis, mostly in immunocompromised patients. To our knowledge, this is the first report of B. holmesii endocarditis on a prosthetic aortic valve. Routine laboratory testing initially misidentified the strain as Acinetobacter sp. Correct identification was achieved by 16S rRNA gene and outer-membrane protein A (ompA) gene sequencing. Interestingly, matrix-assisted laser desorption/ionization timeof-flight mass spectrometry also produced an accurate species-level identification. Subsequent susceptibility testing and review of the literature revealed ceftazidime, cefepime, carbapenems, aminoglycosides, fluoroquinolones, piperacillin/tazobactam, tigecycline and colistin as possible candidates to treat infections caused by B. holmesii.},
  author       = {Jonckheere, Stijn and De Baere, Thierry and Schroeyers, Pascal and Soetens, Oriane and De Bel, Annelies and Surmont, Ignace },
  issn         = {0022-2615},
  journal      = {JOURNAL OF MEDICAL MICROBIOLOGY},
  keyword      = {endocarditis,Bordetella holmesii},
  language     = {eng},
  number       = {6},
  pages        = {874--877},
  title        = {Prosthetic valve endocarditis caused by Bordetella holmesii, an Acinetobacter lookalike},
  url          = {http://dx.doi.org/10.1099/jmm.0.038695-0},
  volume       = {61},
  year         = {2012},
}

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