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Drug resistance mutations in drug-naive HIV type 1 subtype C-infected individuals from rural Malawi

Vijay Bansode, Zuzanna Drebert UGent, Simon AA Travers, Emmanuel Banda, Anna Molesworth, Amelia Crampin, Bagrey Ngwira, Neil French, Judith R Glynn and Grace P McCormack (2011) AIDS RESEARCH AND HUMAN RETROVIRUSES. 27(4). p.439-444
abstract
In this preliminary study we show that in 2008, 3 years after antiretroviral therapy was introduced into the Karonga District, Malawi, a greater than expected number of drug-naive individuals have been infected with HIV-1 subtype C virus harboring major and minor drug resistance mutations (DRMs). From a sample size of 40 reverse transcriptase (RT) consensus sequences from drug-naive individuals we found five showing NRTI and four showing NNRTI mutations with one individual showing both. From 29 protease consensus sequences, again from drug-naive individuals, we found evidence of minor DRMs in three. Additional major and minor DRMs were found in clonal sequences from a number of individuals that were not present in the original consensus sequences. This clearly illustrates the importance of sequencing multiple HIV-1 variants from individuals to fully assess drug resistance.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PROTEASE, REVERSE-TRANSCRIPTASE
journal title
AIDS RESEARCH AND HUMAN RETROVIRUSES
Aids Res. Hum. Retrovir.
volume
27
issue
4
pages
439 - 444
Web of Science type
Article
Web of Science id
000289074400014
JCR category
INFECTIOUS DISEASES
JCR impact factor
2.246 (2011)
JCR rank
42/70 (2011)
JCR quartile
3 (2011)
ISSN
0889-2229
DOI
10.1089/aid.2010.0203
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2121560
handle
http://hdl.handle.net/1854/LU-2121560
date created
2012-05-30 12:15:19
date last changed
2012-06-08 11:00:36
@article{2121560,
  abstract     = {In this preliminary study we show that in 2008, 3 years after antiretroviral therapy was introduced into the Karonga District, Malawi, a greater than expected number of drug-naive individuals have been infected with HIV-1 subtype C virus harboring major and minor drug resistance mutations (DRMs). From a sample size of 40 reverse transcriptase (RT) consensus sequences from drug-naive individuals we found five showing NRTI and four showing NNRTI mutations with one individual showing both. From 29 protease consensus sequences, again from drug-naive individuals, we found evidence of minor DRMs in three. Additional major and minor DRMs were found in clonal sequences from a number of individuals that were not present in the original consensus sequences. This clearly illustrates the importance of sequencing multiple HIV-1 variants from individuals to fully assess drug resistance.},
  author       = {Bansode, Vijay and Drebert, Zuzanna and Travers, Simon AA and Banda, Emmanuel and Molesworth, Anna and Crampin, Amelia and Ngwira, Bagrey and French, Neil and Glynn, Judith R and McCormack, Grace P},
  issn         = {0889-2229},
  journal      = {AIDS RESEARCH AND HUMAN RETROVIRUSES},
  keyword      = {PROTEASE,REVERSE-TRANSCRIPTASE},
  language     = {eng},
  number       = {4},
  pages        = {439--444},
  title        = {Drug resistance mutations in drug-naive HIV type 1 subtype C-infected individuals from rural Malawi},
  url          = {http://dx.doi.org/10.1089/aid.2010.0203},
  volume       = {27},
  year         = {2011},
}

Chicago
Bansode, Vijay, Zuzanna Drebert, Simon AA Travers, Emmanuel Banda, Anna Molesworth, Amelia Crampin, Bagrey Ngwira, Neil French, Judith R Glynn, and Grace P McCormack. 2011. “Drug Resistance Mutations in Drug-naive HIV Type 1 Subtype C-infected Individuals from Rural Malawi.” Aids Research and Human Retroviruses 27 (4): 439–444.
APA
Bansode, V., Drebert, Z., Travers, S. A., Banda, E., Molesworth, A., Crampin, A., Ngwira, B., et al. (2011). Drug resistance mutations in drug-naive HIV type 1 subtype C-infected individuals from rural Malawi. AIDS RESEARCH AND HUMAN RETROVIRUSES, 27(4), 439–444.
Vancouver
1.
Bansode V, Drebert Z, Travers SA, Banda E, Molesworth A, Crampin A, et al. Drug resistance mutations in drug-naive HIV type 1 subtype C-infected individuals from rural Malawi. AIDS RESEARCH AND HUMAN RETROVIRUSES. 2011;27(4):439–44.
MLA
Bansode, Vijay, Zuzanna Drebert, Simon AA Travers, et al. “Drug Resistance Mutations in Drug-naive HIV Type 1 Subtype C-infected Individuals from Rural Malawi.” AIDS RESEARCH AND HUMAN RETROVIRUSES 27.4 (2011): 439–444. Print.