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Anthelmintic tolerance in free-living and facultative parasitic isolates of Halicephalobus (Panagrolaimidae)

Pamela Fonderie, Wim Bert UGent, Frederik Hendrickx UGent, Wouter Houthoofd UGent and Tom Moens UGent (2012) PARASITOLOGY. 139(10). p.1301-1308
abstract
Studies on anthelmintic resistance in equine parasites do not include facultative parasites. Halicephalobus gingivalis is a free-living bacteriovorous nematode and a known facultative parasite of horses with a strong indication of some form of tolerance to common anthelmintic drugs. This research presents the results of an in vitro study on the anthelmintic tolerance of several isolates of Halicephalobus to thiabendazole and ivermectin using an adaptation of the Micro-Agar Larval Development Test hereby focusing on egg hatching and larval development. Panagrellus redivivus and Panagrolaimus superbus were included as a positive control. The results generally show that the anthelmintic tolerance of Halicephalobus to both thiabendazole and ivermectin was considerably higher than that of the closely related Panagrolaimidae and, comparing to other studies, than that of obligatory equine parasites. Our results further reveal a remarkable trend of increasing tolerance from fully free-living isolates towards horse-associated isolates. In vitro anthelmintic testing with free-living and facultative parasitic nematodes offers the advantage of observing drug effect on the complete lifecycle as opposed to obligatory parasites which can only be followed until the third larval stage. We therefore propose Halicephalobus gingivalis as an experimental tool to deepen our understanding of the biology of anthelmintic tolerance.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
facultative parasitism, ivermectin, MALDT method, model organism, thiabendazole
journal title
PARASITOLOGY
Parasitology
volume
139
issue
10
pages
1301 - 1308
Web of Science type
Article
Web of Science id
000308657800007
JCR category
PARASITOLOGY
JCR impact factor
2.355 (2012)
JCR rank
14/34 (2012)
JCR quartile
2 (2012)
ISSN
0031-1820
DOI
10.1017/S0031182012000558
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2120915
handle
http://hdl.handle.net/1854/LU-2120915
date created
2012-05-30 10:44:46
date last changed
2016-12-19 15:42:03
@article{2120915,
  abstract     = {Studies on anthelmintic resistance in equine parasites do not include facultative parasites. Halicephalobus gingivalis is a free-living bacteriovorous nematode and a known facultative parasite of horses with a strong indication of some form of tolerance to common anthelmintic drugs. This research presents the results of an in vitro study on the anthelmintic tolerance of several isolates of Halicephalobus to thiabendazole and ivermectin using an adaptation of the Micro-Agar Larval Development Test hereby focusing on egg hatching and larval development. Panagrellus redivivus and Panagrolaimus superbus were included as a positive control. The results generally show that the anthelmintic tolerance of Halicephalobus to both thiabendazole and ivermectin was considerably higher than that of the closely related Panagrolaimidae and, comparing to other studies, than that of obligatory equine parasites. Our results further reveal a remarkable trend of increasing tolerance from fully free-living isolates towards horse-associated isolates. In vitro anthelmintic testing with free-living and facultative parasitic nematodes offers the advantage of observing drug effect on the complete lifecycle as opposed to obligatory parasites which can only be followed until the third larval stage. We therefore propose Halicephalobus gingivalis as an experimental tool to deepen our understanding of the biology of anthelmintic tolerance.},
  author       = {Fonderie, Pamela and Bert, Wim and Hendrickx, Frederik and Houthoofd, Wouter and Moens, Tom},
  issn         = {0031-1820},
  journal      = {PARASITOLOGY},
  keyword      = {facultative parasitism,ivermectin,MALDT method,model organism,thiabendazole},
  language     = {eng},
  number       = {10},
  pages        = {1301--1308},
  title        = {Anthelmintic tolerance in free-living and facultative parasitic isolates of Halicephalobus (Panagrolaimidae)},
  url          = {http://dx.doi.org/10.1017/S0031182012000558},
  volume       = {139},
  year         = {2012},
}

Chicago
Fonderie, Pamela, Wim Bert, Frederik Hendrickx, Wouter Houthoofd, and Tom Moens. 2012. “Anthelmintic Tolerance in Free-living and Facultative Parasitic Isolates of Halicephalobus (Panagrolaimidae).” Parasitology 139 (10): 1301–1308.
APA
Fonderie, P., Bert, W., Hendrickx, F., Houthoofd, W., & Moens, T. (2012). Anthelmintic tolerance in free-living and facultative parasitic isolates of Halicephalobus (Panagrolaimidae). PARASITOLOGY, 139(10), 1301–1308.
Vancouver
1.
Fonderie P, Bert W, Hendrickx F, Houthoofd W, Moens T. Anthelmintic tolerance in free-living and facultative parasitic isolates of Halicephalobus (Panagrolaimidae). PARASITOLOGY. 2012;139(10):1301–8.
MLA
Fonderie, Pamela, Wim Bert, Frederik Hendrickx, et al. “Anthelmintic Tolerance in Free-living and Facultative Parasitic Isolates of Halicephalobus (Panagrolaimidae).” PARASITOLOGY 139.10 (2012): 1301–1308. Print.