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Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma

Ken Coppieters UGent, A Wiberg, SM Tracy and MG von Herrath (2012) CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 168(1). p.5-11
abstract
Convincing evidence now indicates that viruses are associated with type 1 diabetes (T1D) development and progression. Human enteroviruses (HEV) have emerged as prime suspects, based on detection frequencies around clinical onset in patients and their ability to rapidly hyperglycaemia trigger in the non-obese diabetic (NOD) mouse. Whether or not HEV can truly cause islet autoimmunity or, rather, act by accelerating ongoing insulitis remains a matter of debate. In view of the disease's globally rising incidence it is hypothesized that improved hygiene standards may reduce the immune system's ability to appropriately respond to viral infections. Arguments in favour of and against viral infections as major aetiological factors in T1D will be discussed in conjunction with potential pathological scenarios. More profound insights into the intricate relationship between viruses and their autoimmunity-prone host may lead ultimately to opportunities for early intervention through immune modulation or vaccination.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
beta cells, autoimmunity, hygiene, type 1 diabetes, viruses, 99TH DAHLEM CONFERENCE, BETA-CELLS, GLUTAMATE-DECARBOXYLASE, MOLECULAR MIMICRY, COXSACKIEVIRUS B3, PANCREATIC-ISLETS, HYGIENE HYPOTHESIS, SEQUENCE HOMOLOGY, TRANSGENIC MODEL, IMMUNE-RESPONSE
journal title
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Clin. Exp. Immunol.
volume
168
issue
1
pages
5 - 11
Web of Science type
Review
Web of Science id
000300974800002
JCR category
IMMUNOLOGY
JCR impact factor
3.409 (2012)
JCR rank
52/134 (2012)
JCR quartile
2 (2012)
ISSN
0009-9104
DOI
10.1111/j.1365-2249.2011.04554.x
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2120325
handle
http://hdl.handle.net/1854/LU-2120325
date created
2012-05-30 10:01:14
date last changed
2012-06-07 13:32:52
@article{2120325,
  abstract     = {Convincing evidence now indicates that viruses are associated with type 1 diabetes (T1D) development and progression. Human enteroviruses (HEV) have emerged as prime suspects, based on detection frequencies around clinical onset in patients and their ability to rapidly hyperglycaemia trigger in the non-obese diabetic (NOD) mouse. Whether or not HEV can truly cause islet autoimmunity or, rather, act by accelerating ongoing insulitis remains a matter of debate. In view of the disease's globally rising incidence it is hypothesized that improved hygiene standards may reduce the immune system's ability to appropriately respond to viral infections. Arguments in favour of and against viral infections as major aetiological factors in T1D will be discussed in conjunction with potential pathological scenarios. More profound insights into the intricate relationship between viruses and their autoimmunity-prone host may lead ultimately to opportunities for early intervention through immune modulation or vaccination.},
  author       = {Coppieters, Ken and Wiberg, A and Tracy, SM and von Herrath, MG},
  issn         = {0009-9104},
  journal      = {CLINICAL AND EXPERIMENTAL IMMUNOLOGY},
  keyword      = {beta cells,autoimmunity,hygiene,type 1 diabetes,viruses,99TH DAHLEM CONFERENCE,BETA-CELLS,GLUTAMATE-DECARBOXYLASE,MOLECULAR MIMICRY,COXSACKIEVIRUS B3,PANCREATIC-ISLETS,HYGIENE HYPOTHESIS,SEQUENCE HOMOLOGY,TRANSGENIC MODEL,IMMUNE-RESPONSE},
  language     = {eng},
  number       = {1},
  pages        = {5--11},
  title        = {Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma},
  url          = {http://dx.doi.org/10.1111/j.1365-2249.2011.04554.x},
  volume       = {168},
  year         = {2012},
}

Chicago
Coppieters, Ken, A Wiberg, SM Tracy, and MG von Herrath. 2012. “Immunology in the Clinic Review Series: Focus on Type 1 Diabetes and Viruses: The Role of Viruses in Type 1 Diabetes: a Difficult Dilemma.” Clinical and Experimental Immunology 168 (1): 5–11.
APA
Coppieters, K., Wiberg, A., Tracy, S., & von Herrath, M. (2012). Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 168(1), 5–11.
Vancouver
1.
Coppieters K, Wiberg A, Tracy S, von Herrath M. Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2012;168(1):5–11.
MLA
Coppieters, Ken, A Wiberg, SM Tracy, et al. “Immunology in the Clinic Review Series: Focus on Type 1 Diabetes and Viruses: The Role of Viruses in Type 1 Diabetes: a Difficult Dilemma.” CLINICAL AND EXPERIMENTAL IMMUNOLOGY 168.1 (2012): 5–11. Print.