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Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma

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Abstract
Convincing evidence now indicates that viruses are associated with type 1 diabetes (T1D) development and progression. Human enteroviruses (HEV) have emerged as prime suspects, based on detection frequencies around clinical onset in patients and their ability to rapidly hyperglycaemia trigger in the non-obese diabetic (NOD) mouse. Whether or not HEV can truly cause islet autoimmunity or, rather, act by accelerating ongoing insulitis remains a matter of debate. In view of the disease's globally rising incidence it is hypothesized that improved hygiene standards may reduce the immune system's ability to appropriately respond to viral infections. Arguments in favour of and against viral infections as major aetiological factors in T1D will be discussed in conjunction with potential pathological scenarios. More profound insights into the intricate relationship between viruses and their autoimmunity-prone host may lead ultimately to opportunities for early intervention through immune modulation or vaccination.
Keywords
beta cells, autoimmunity, hygiene, type 1 diabetes, viruses, 99TH DAHLEM CONFERENCE, BETA-CELLS, GLUTAMATE-DECARBOXYLASE, MOLECULAR MIMICRY, COXSACKIEVIRUS B3, PANCREATIC-ISLETS, HYGIENE HYPOTHESIS, SEQUENCE HOMOLOGY, TRANSGENIC MODEL, IMMUNE-RESPONSE

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Citation

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Chicago
Coppieters, Ken, A Wiberg, SM Tracy, and MG von Herrath. 2012. “Immunology in the Clinic Review Series: Focus on Type 1 Diabetes and Viruses: The Role of Viruses in Type 1 Diabetes: a Difficult Dilemma.” Clinical and Experimental Immunology 168 (1): 5–11.
APA
Coppieters, K., Wiberg, A., Tracy, S., & von Herrath, M. (2012). Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 168(1), 5–11.
Vancouver
1.
Coppieters K, Wiberg A, Tracy S, von Herrath M. Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2012;168(1):5–11.
MLA
Coppieters, Ken, A Wiberg, SM Tracy, et al. “Immunology in the Clinic Review Series: Focus on Type 1 Diabetes and Viruses: The Role of Viruses in Type 1 Diabetes: a Difficult Dilemma.” CLINICAL AND EXPERIMENTAL IMMUNOLOGY 168.1 (2012): 5–11. Print.
@article{2120325,
  abstract     = {Convincing evidence now indicates that viruses are associated with type 1 diabetes (T1D) development and progression. Human enteroviruses (HEV) have emerged as prime suspects, based on detection frequencies around clinical onset in patients and their ability to rapidly hyperglycaemia trigger in the non-obese diabetic (NOD) mouse. Whether or not HEV can truly cause islet autoimmunity or, rather, act by accelerating ongoing insulitis remains a matter of debate. In view of the disease's globally rising incidence it is hypothesized that improved hygiene standards may reduce the immune system's ability to appropriately respond to viral infections. Arguments in favour of and against viral infections as major aetiological factors in T1D will be discussed in conjunction with potential pathological scenarios. More profound insights into the intricate relationship between viruses and their autoimmunity-prone host may lead ultimately to opportunities for early intervention through immune modulation or vaccination.},
  author       = {Coppieters, Ken and Wiberg, A and Tracy, SM and von Herrath, MG},
  issn         = {0009-9104},
  journal      = {CLINICAL AND EXPERIMENTAL IMMUNOLOGY},
  keyword      = {beta cells,autoimmunity,hygiene,type 1 diabetes,viruses,99TH DAHLEM CONFERENCE,BETA-CELLS,GLUTAMATE-DECARBOXYLASE,MOLECULAR MIMICRY,COXSACKIEVIRUS B3,PANCREATIC-ISLETS,HYGIENE HYPOTHESIS,SEQUENCE HOMOLOGY,TRANSGENIC MODEL,IMMUNE-RESPONSE},
  language     = {eng},
  number       = {1},
  pages        = {5--11},
  title        = {Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma},
  url          = {http://dx.doi.org/10.1111/j.1365-2249.2011.04554.x},
  volume       = {168},
  year         = {2012},
}

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