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Fetal microchimeric cells in the blood of women with an autoimmune thyroid disease

Trees Lepez UGent, Mado Vandewoestyne UGent, Filip Van Nieuwerburgh UGent, Kris Poppe, Brigit Velkeniers and Dieter Deforce UGent (2012) Autoimmunity, 8th International congress, Abstracts.
abstract
Context: Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), two autoimmune thyroid diseases (AITD), occur more frequently in women than in men and show an increased incidence in the years following parturition. Persisting fetal cells could play a role in the development of these diseases. Objective: Aim of this study was to detect and characterize fetal cells in blood of postpartum women with and without an AITD. Participants: Eleven patients with an AITD and ten healthy volunteers, all given birth to a son maximum 5 years before analysis, and three women who never had been pregnant, were included. None of them had any other disease of the thyroid which could interfere with the results obtained. Methods: FISH and repeated FISH were used to count the number of male fetal cells. Furthermore, the fetal cells were further characterized. Results: In patients with HT, 7 to 11 fetal cells per 1.000.000 maternal cells were detected, compared to 14 to 29 fetal cells in patients with GD (p= 0,0061). In patients with HT, mainly fetal CD8+ T cells were found, while in patients with GD, fetal B and CD4+ T cells were detected. In healthy volunteers with son, 0 to 5 fetal cells were observed, which was significantly less than the number observed in patients (p= 0,0002). In women who never had been pregnant, no male cells were detected. Conclusion: Our study shows a clear association between fetal microchimeric cells and autoimmune thyroid diseases.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
in
Autoimmunity, 8th International congress, Abstracts
conference name
8th International congress on Autoimmunity
conference location
Granada, Spain
conference start
2012-05-09
conference end
2012-05-13
language
English
UGent publication?
yes
classification
C3
id
2118820
handle
http://hdl.handle.net/1854/LU-2118820
date created
2012-05-30 08:43:16
date last changed
2012-06-28 12:00:17
@inproceedings{2118820,
  abstract     = {Context: Hashimoto{\textquoteright}s thyroiditis (HT) and Graves{\textquoteright} disease (GD), two autoimmune thyroid diseases (AITD), occur more frequently in women than in men and show an increased incidence in the years following parturition. Persisting fetal cells could play a role in the development of these diseases. 
Objective: Aim of this study was to detect and characterize fetal cells in blood of postpartum women with and without an AITD. 
Participants: Eleven patients with an AITD and ten healthy volunteers, all given birth to a son maximum 5 years before analysis, and three women who never had been pregnant, were included. None of them had any other disease of the thyroid which could interfere with the results obtained. 
Methods: FISH and repeated FISH were used to count the number of male fetal cells. Furthermore, the fetal cells were further characterized. 
Results: In patients with HT, 7 to 11 fetal cells per 1.000.000 maternal cells were detected, compared to 14 to 29 fetal cells in patients with GD (p= 0,0061). In patients with HT, mainly fetal CD8+ T cells were found, while in patients with GD, fetal B and CD4+ T cells were detected. In healthy volunteers with son, 0 to 5 fetal cells were observed, which was significantly less than the number observed in patients (p= 0,0002). In women who never had been pregnant, no male cells were detected.
Conclusion: Our study shows a clear association between fetal microchimeric cells and autoimmune thyroid diseases.},
  author       = {Lepez, Trees and Vandewoestyne, Mado and Van Nieuwerburgh, Filip and Poppe, Kris  and Velkeniers, Brigit  and Deforce, Dieter},
  booktitle    = {Autoimmunity, 8th International congress, Abstracts},
  language     = {eng},
  location     = {Granada, Spain},
  title        = {Fetal microchimeric cells in the blood of women with an autoimmune thyroid disease},
  year         = {2012},
}

Chicago
Lepez, Trees, Mado Vandewoestyne, Filip Van Nieuwerburgh, Kris Poppe, Brigit Velkeniers, and Dieter Deforce. 2012. “Fetal Microchimeric Cells in the Blood of Women with an Autoimmune Thyroid Disease.” In Autoimmunity, 8th International Congress, Abstracts.
APA
Lepez, T., Vandewoestyne, M., Van Nieuwerburgh, F., Poppe, K., Velkeniers, B., & Deforce, D. (2012). Fetal microchimeric cells in the blood of women with an autoimmune thyroid disease. Autoimmunity, 8th International congress, Abstracts. Presented at the 8th International congress on Autoimmunity.
Vancouver
1.
Lepez T, Vandewoestyne M, Van Nieuwerburgh F, Poppe K, Velkeniers B, Deforce D. Fetal microchimeric cells in the blood of women with an autoimmune thyroid disease. Autoimmunity, 8th International congress, Abstracts. 2012.
MLA
Lepez, Trees, Mado Vandewoestyne, Filip Van Nieuwerburgh, et al. “Fetal Microchimeric Cells in the Blood of Women with an Autoimmune Thyroid Disease.” Autoimmunity, 8th International Congress, Abstracts. 2012. Print.