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Fetal microchimeric cells in the blood of women with an autoimmune thyroid disease

Author
Organization
Abstract
Context: Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), two autoimmune thyroid diseases (AITD), occur more frequently in women than in men and show an increased incidence in the years following parturition. Persisting fetal cells could play a role in the development of these diseases. Objective: Aim of this study was to detect and characterize fetal cells in blood of postpartum women with and without an AITD. Participants: Eleven patients with an AITD and ten healthy volunteers, all given birth to a son maximum 5 years before analysis, and three women who never had been pregnant, were included. None of them had any other disease of the thyroid which could interfere with the results obtained. Methods: FISH and repeated FISH were used to count the number of male fetal cells. Furthermore, the fetal cells were further characterized. Results: In patients with HT, 7 to 11 fetal cells per 1.000.000 maternal cells were detected, compared to 14 to 29 fetal cells in patients with GD (p= 0,0061). In patients with HT, mainly fetal CD8+ T cells were found, while in patients with GD, fetal B and CD4+ T cells were detected. In healthy volunteers with son, 0 to 5 fetal cells were observed, which was significantly less than the number observed in patients (p= 0,0002). In women who never had been pregnant, no male cells were detected. Conclusion: Our study shows a clear association between fetal microchimeric cells and autoimmune thyroid diseases.

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Chicago
Lepez, Trees, Mado Vandewoestyne, Filip Van Nieuwerburgh, Kris Poppe, Brigit Velkeniers, and Dieter Deforce. 2012. “Fetal Microchimeric Cells in the Blood of Women with an Autoimmune Thyroid Disease.” In Autoimmunity, 8th International Congress, Abstracts.
APA
Lepez, T., Vandewoestyne, M., Van Nieuwerburgh, F., Poppe, K., Velkeniers, B., & Deforce, D. (2012). Fetal microchimeric cells in the blood of women with an autoimmune thyroid disease. Autoimmunity, 8th International congress, Abstracts. Presented at the 8th International congress on Autoimmunity.
Vancouver
1.
Lepez T, Vandewoestyne M, Van Nieuwerburgh F, Poppe K, Velkeniers B, Deforce D. Fetal microchimeric cells in the blood of women with an autoimmune thyroid disease. Autoimmunity, 8th International congress, Abstracts. 2012.
MLA
Lepez, Trees, Mado Vandewoestyne, Filip Van Nieuwerburgh, et al. “Fetal Microchimeric Cells in the Blood of Women with an Autoimmune Thyroid Disease.” Autoimmunity, 8th International Congress, Abstracts. 2012. Print.
@inproceedings{2118820,
  abstract     = {Context: Hashimoto{\textquoteright}s thyroiditis (HT) and Graves{\textquoteright} disease (GD), two autoimmune thyroid diseases (AITD), occur more frequently in women than in men and show an increased incidence in the years following parturition. Persisting fetal cells could play a role in the development of these diseases. 
Objective: Aim of this study was to detect and characterize fetal cells in blood of postpartum women with and without an AITD. 
Participants: Eleven patients with an AITD and ten healthy volunteers, all given birth to a son maximum 5 years before analysis, and three women who never had been pregnant, were included. None of them had any other disease of the thyroid which could interfere with the results obtained. 
Methods: FISH and repeated FISH were used to count the number of male fetal cells. Furthermore, the fetal cells were further characterized. 
Results: In patients with HT, 7 to 11 fetal cells per 1.000.000 maternal cells were detected, compared to 14 to 29 fetal cells in patients with GD (p= 0,0061). In patients with HT, mainly fetal CD8+ T cells were found, while in patients with GD, fetal B and CD4+ T cells were detected. In healthy volunteers with son, 0 to 5 fetal cells were observed, which was significantly less than the number observed in patients (p= 0,0002). In women who never had been pregnant, no male cells were detected.
Conclusion: Our study shows a clear association between fetal microchimeric cells and autoimmune thyroid diseases.},
  author       = {Lepez, Trees and Vandewoestyne, Mado and Van Nieuwerburgh, Filip and Poppe, Kris  and Velkeniers, Brigit  and Deforce, Dieter},
  booktitle    = {Autoimmunity, 8th International congress, Abstracts},
  language     = {eng},
  location     = {Granada, Spain},
  title        = {Fetal microchimeric cells in the blood of women with an autoimmune thyroid disease},
  year         = {2012},
}