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Absolute quantification for small-animal PET

Vincent Keereman UGent, Roel Van Holen UGent, Christian Vanhove UGent, Pieter Mollet UGent and Stefaan Vandenberghe UGent (2011) IEEE Nuclear Science Symposium Conference Record. p.3715-3719
abstract
Quantification is important in preclinical PET studies. To achieve absolute quantification, an accurate reconstruction algorithm is necessary. Such an algorithm includes corrections for different effects such as geometric sensitivity of the scanner, detection efficiency, attenuation, scatter and random coincidences. In this work we present a method for performing absolute quantification on the LabPET system. All acquisitions were done on a GE Triumph system. This tri-modality system consists of a micro-PET (LabPET), micro-CT (X-O) and micro-SPECT (X-SPECT) scanner. Three PET scans were done. In the first scan 5 vials with different activity concentrations of F-18-FDG were scanned. The total activity inside the scanner was 80 MBq. The second scan was performed after 4 hours when the total activity in the scanner had decayed to 20 MBq. In the third scan 3 vials and 1 sphere were scanned with a total activity of 20 MBq. Before each PET scan a micro-CT scan was acquired. Point sources with a known activity were placed inside the field of view. The counts obtained in these point sources are used to obtain a correction factor for absolute sensitivity. Reconstruction was done using a 3D ML-EM reconstruction with micro-CT based attenuation correction. VOIs were drawn over the vials and the sphere in the reconstructed images. The total activity in the VOIs was calculated using the correction factor for absolute sensitivity. It was compared to the activity measured in a dose calibrator. The average quantification error was 56 %, 6.4 % and 0.6 % for the first, second and third scan. The high error in the first scan is explained by count rate effects, as 80 MBq can be considered a high activity level for this system. The feasibility of absolute quantification on the LabPET system was demonstrated. When the count rate is below 20 MBq absolute quantification is possible with an average quantification error smaller than 6.4 %.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
POSITRON-EMISSION-TOMOGRAPHY, TUMOR RESPONSE, MICROPET, THERAPY, micro-PET, micro-CT, quantification, attenuation correction
in
IEEE Nuclear Science Symposium Conference Record
issue title
2011 IEEE Nuclear science symposium and medical imaging conference (NSS/MIC)
pages
3715 - 3719
publisher
IEEE
place of publication
Piscataway, NJ, USA
conference name
2011 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC 2011)
conference location
Valencia, Spain
conference start
2011-10-23
conference end
2011-10-29
Web of Science type
Proceedings Paper
Web of Science id
000304755603212
ISSN
1082-3654
ISBN
9781467301183
DOI
10.1109/NSSMIC.2011.6153701
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
P1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2118571
handle
http://hdl.handle.net/1854/LU-2118571
date created
2012-05-30 07:50:47
date last changed
2013-02-27 09:09:13
@inproceedings{2118571,
  abstract     = {Quantification is important in preclinical PET studies. To achieve absolute quantification, an accurate reconstruction algorithm is necessary. Such an algorithm includes corrections for different effects such as geometric sensitivity of the scanner, detection efficiency, attenuation, scatter and random coincidences. In this work we present a method for performing absolute quantification on the LabPET system. All acquisitions were done on a GE Triumph system. This tri-modality system consists of a micro-PET (LabPET), micro-CT (X-O) and micro-SPECT (X-SPECT) scanner. Three PET scans were done. In the first scan 5 vials with different activity concentrations of F-18-FDG were scanned. The total activity inside the scanner was 80 MBq. The second scan was performed after 4 hours when the total activity in the scanner had decayed to 20 MBq. In the third scan 3 vials and 1 sphere were scanned with a total activity of 20 MBq. Before each PET scan a micro-CT scan was acquired. Point sources with a known activity were placed inside the field of view. The counts obtained in these point sources are used to obtain a correction factor for absolute sensitivity. Reconstruction was done using a 3D ML-EM reconstruction with micro-CT based attenuation correction. VOIs were drawn over the vials and the sphere in the reconstructed images. The total activity in the VOIs was calculated using the correction factor for absolute sensitivity. It was compared to the activity measured in a dose calibrator. The average quantification error was 56 \%, 6.4 \% and 0.6 \% for the first, second and third scan. The high error in the first scan is explained by count rate effects, as 80 MBq can be considered a high activity level for this system. The feasibility of absolute quantification on the LabPET system was demonstrated. When the count rate is below 20 MBq absolute quantification is possible with an average quantification error smaller than 6.4 \%.},
  author       = {Keereman, Vincent and Van Holen, Roel and Vanhove, Christian and Mollet, Pieter and Vandenberghe, Stefaan},
  booktitle    = {IEEE Nuclear Science Symposium Conference Record},
  isbn         = {9781467301183},
  issn         = {1082-3654},
  keyword      = {POSITRON-EMISSION-TOMOGRAPHY,TUMOR RESPONSE,MICROPET,THERAPY,micro-PET,micro-CT,quantification,attenuation correction},
  language     = {eng},
  location     = {Valencia, Spain},
  pages        = {3715--3719},
  publisher    = {IEEE},
  title        = {Absolute quantification for small-animal PET},
  url          = {http://dx.doi.org/10.1109/NSSMIC.2011.6153701},
  year         = {2011},
}

Chicago
Keereman, Vincent, Roel Van Holen, Christian Vanhove, Pieter Mollet, and Stefaan Vandenberghe. 2011. “Absolute Quantification for Small-animal PET.” In IEEE Nuclear Science Symposium Conference Record, 3715–3719. Piscataway, NJ, USA: IEEE.
APA
Keereman, V., Van Holen, R., Vanhove, C., Mollet, P., & Vandenberghe, S. (2011). Absolute quantification for small-animal PET. IEEE Nuclear Science Symposium Conference Record (pp. 3715–3719). Presented at the 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC 2011), Piscataway, NJ, USA: IEEE.
Vancouver
1.
Keereman V, Van Holen R, Vanhove C, Mollet P, Vandenberghe S. Absolute quantification for small-animal PET. IEEE Nuclear Science Symposium Conference Record. Piscataway, NJ, USA: IEEE; 2011. p. 3715–9.
MLA
Keereman, Vincent, Roel Van Holen, Christian Vanhove, et al. “Absolute Quantification for Small-animal PET.” IEEE Nuclear Science Symposium Conference Record. Piscataway, NJ, USA: IEEE, 2011. 3715–3719. Print.