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Pseudorabies virus (PRV)-specific antibodies suppress intracellular viral protein levels in PRV-infected monocytes

(2003) JOURNAL OF GENERAL VIROLOGY. 84(11). p.2969-2973
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Abstract
Blood monocytes infected with pseudorabies virus (PRV), a swine alphaherpesvirus, are not eliminated efficiently by anti body-dependent immunity and may occasionally transport PRV to the pregnant uterus of vaccinated animals. This study examines in vitro the long-term fate of PRV-infected monocytes cultivated in the presence of porcine PRV-specific antibodies. All monocytes were infected and expressed viral late proteins, and 30 % of PRV-infected monocytes cultivated with PRV-specific antibodies survived up to 194 h post-infection (p.i.), the end of the experiment (compared to 0 % for cells cultivated with PRV-negative antibodies). Of these surviving cells, +/- 75 % no longer expressed microscopically detectable viral late proteins from 144 h p.i. onwards. Remarkably, monocytes infected with a PRV gB-null virus did not survive in the presence of PRV-specific; antibodies. These data suggest that PRV-specific antibodies suppress viral protein levels in infected monocytes, perhaps helping the virus to persist and reach internal organs in vaccinated animals.
Keywords
TO-CELL SPREAD, AUJESZKYS-DISEASE VIRUS, INDUCED INTERNALIZATION, ALPHAVIRUS INFECTION, CYTOPLASMIC TAIL, VACCINATED SOWS, SINDBIS VIRUS, GLYCOPROTEINS, NEURONS, PIGS

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Citation

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MLA
Favoreel, Herman, Gerlinde Van de Walle, Hans Nauwynck, et al. “Pseudorabies Virus (PRV)-specific Antibodies Suppress Intracellular Viral Protein Levels in PRV-infected Monocytes.” JOURNAL OF GENERAL VIROLOGY 84.11 (2003): 2969–2973. Print.
APA
Favoreel, H., Van de Walle, G., Nauwynck, H., Mettenleiter, T. C., & Pensaert, M. (2003). Pseudorabies virus (PRV)-specific antibodies suppress intracellular viral protein levels in PRV-infected monocytes. JOURNAL OF GENERAL VIROLOGY, 84(11), 2969–2973.
Chicago author-date
Favoreel, Herman, Gerlinde Van de Walle, Hans Nauwynck, Thomas C Mettenleiter, and Maurice Pensaert. 2003. “Pseudorabies Virus (PRV)-specific Antibodies Suppress Intracellular Viral Protein Levels in PRV-infected Monocytes.” Journal of General Virology 84 (11): 2969–2973.
Chicago author-date (all authors)
Favoreel, Herman, Gerlinde Van de Walle, Hans Nauwynck, Thomas C Mettenleiter, and Maurice Pensaert. 2003. “Pseudorabies Virus (PRV)-specific Antibodies Suppress Intracellular Viral Protein Levels in PRV-infected Monocytes.” Journal of General Virology 84 (11): 2969–2973.
Vancouver
1.
Favoreel H, Van de Walle G, Nauwynck H, Mettenleiter TC, Pensaert M. Pseudorabies virus (PRV)-specific antibodies suppress intracellular viral protein levels in PRV-infected monocytes. JOURNAL OF GENERAL VIROLOGY. 2003;84(11):2969–73.
IEEE
[1]
H. Favoreel, G. Van de Walle, H. Nauwynck, T. C. Mettenleiter, and M. Pensaert, “Pseudorabies virus (PRV)-specific antibodies suppress intracellular viral protein levels in PRV-infected monocytes,” JOURNAL OF GENERAL VIROLOGY, vol. 84, no. 11, pp. 2969–2973, 2003.
@article{211728,
  abstract     = {Blood monocytes infected with pseudorabies virus (PRV), a swine alphaherpesvirus, are not eliminated efficiently by anti body-dependent immunity and may occasionally transport PRV to the pregnant uterus of vaccinated animals. This study examines in vitro the long-term fate of PRV-infected monocytes cultivated in the presence of porcine PRV-specific antibodies. All monocytes were infected and expressed viral late proteins, and 30 % of PRV-infected monocytes cultivated with PRV-specific antibodies survived up to 194 h post-infection (p.i.), the end of the experiment (compared to 0 % for cells cultivated with PRV-negative antibodies). Of these surviving cells, +/- 75 % no longer expressed microscopically detectable viral late proteins from 144 h p.i. onwards. Remarkably, monocytes infected with a PRV gB-null virus did not survive in the presence of PRV-specific; antibodies. These data suggest that PRV-specific antibodies suppress viral protein levels in infected monocytes, perhaps helping the virus to persist and reach internal organs in vaccinated animals.},
  author       = {Favoreel, Herman and Van de Walle, Gerlinde and Nauwynck, Hans and Mettenleiter, Thomas C and Pensaert, Maurice},
  issn         = {0022-1317},
  journal      = {JOURNAL OF GENERAL VIROLOGY},
  keywords     = {TO-CELL SPREAD,AUJESZKYS-DISEASE VIRUS,INDUCED INTERNALIZATION,ALPHAVIRUS INFECTION,CYTOPLASMIC TAIL,VACCINATED SOWS,SINDBIS VIRUS,GLYCOPROTEINS,NEURONS,PIGS},
  language     = {eng},
  number       = {11},
  pages        = {2969--2973},
  title        = {Pseudorabies virus (PRV)-specific antibodies suppress intracellular viral protein levels in PRV-infected monocytes},
  url          = {http://dx.doi.org/10.1099/vir.0.19281-0},
  volume       = {84},
  year         = {2003},
}

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