Advanced search
1 file | 122.77 KB

The haptoglobin phenotype influences the risk of cutaneous squamous cell carcinoma in kidney transplant patients

Reinhart Speeckaert (UGent) , Lieve Brochez (UGent) , Jo Lambert (UGent) , Nanja van Geel (UGent) , Marijn Speeckaert (UGent) , LAURENS CLAEYS (UGent) , Michel Langlois (UGent) , C Van Laer, Patrick Peeters (UGent) and Joris Delanghe (UGent)
Author
Organization
Abstract
Background : Cutaneous squamous cell carcinoma (SCC) is the most frequent skin cancer after organ transplantation. Currently, the pre-identification of transplant patients at increased risk for non-melanoma skin cancer remains difficult. Objective : To investigate the Hp polymorphism as a marker for the identification of a subset of patients with an increased susceptibility to develop SCC/Bowen's disease. Methods : Haptoglobin phenotyping was performed with haemoglobin-supplemented starch gel electrophoresis in 300 kidney transplant patients. High-performance gel permeation chromatography was used in case of low serum haptoglobin concentration. Results : Cox regression analysis (adjusted for age, gender and Mediterranean origin) showed a significant association of the Hp 1-1 phenotype with a higher risk of SCC/Bowen's disease (P = 0.035) and multiple primary SCCs (P = 0.002). No significant difference between the Hp phenotypes was found for the development of Bowen's disease and SCCs in the first 10 years following renal transplantation. However, after a follow-up of >10 years, a significant association between the Hp 1-1 phenotype and the occurrence of Bowen's disease and SCC was reported (P = 0.002 and P = 0.001 respectively). Conclusions : This study shows an increased risk for the development of (multiple) SCCs in kidney transplant patients with the Hp 1-1 phenotype. This finding points to the role of Hp 1-1 phenotype as an important predictor in identifying a subset of patients with an increased need for preventive measures and is in agreement with the decreased anti-inflammatory capacity of this phenotype.
Keywords
RECIPIENTS, INDIVIDUALS, FREE HEMOGLOBIN, CERVICAL-CANCER, HUMAN-PAPILLOMAVIRUS INFECTION, EPIDERMODYSPLASIA-VERRUCIFORMIS, PREMALIGNANT SKIN-LESIONS, POLYMORPHISM, ASSOCIATION, MULTICENTER

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 122.77 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Speeckaert, Reinhart, Lieve Brochez, Jo Lambert, Nanja van Geel, Marijn Speeckaert, LAURENS CLAEYS, Michel Langlois, C Van Laer, PATRICK PEETERS, and Joris Delanghe. 2012. “The Haptoglobin Phenotype Influences the Risk of Cutaneous Squamous Cell Carcinoma in Kidney Transplant Patients.” Journal of the European Academy of Dermatology and Venereology 26 (5): 566–571.
APA
Speeckaert, R., Brochez, L., Lambert, J., van Geel, N., Speeckaert, M., CLAEYS, L., Langlois, M., et al. (2012). The haptoglobin phenotype influences the risk of cutaneous squamous cell carcinoma in kidney transplant patients. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 26(5), 566–571.
Vancouver
1.
Speeckaert R, Brochez L, Lambert J, van Geel N, Speeckaert M, CLAEYS L, et al. The haptoglobin phenotype influences the risk of cutaneous squamous cell carcinoma in kidney transplant patients. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 2012;26(5):566–71.
MLA
Speeckaert, Reinhart, Lieve Brochez, Jo Lambert, et al. “The Haptoglobin Phenotype Influences the Risk of Cutaneous Squamous Cell Carcinoma in Kidney Transplant Patients.” JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 26.5 (2012): 566–571. Print.
@article{2117237,
  abstract     = {Background : Cutaneous squamous cell carcinoma (SCC) is the most frequent skin cancer after organ transplantation. Currently, the pre-identification of transplant patients at increased risk for non-melanoma skin cancer remains difficult.
Objective : To investigate the Hp polymorphism as a marker for the identification of a subset of patients with an increased susceptibility to develop SCC/Bowen's disease.
Methods : Haptoglobin phenotyping was performed with haemoglobin-supplemented starch gel electrophoresis in 300 kidney transplant patients. High-performance gel permeation chromatography was used in case of low serum haptoglobin concentration.
Results : Cox regression analysis (adjusted for age, gender and Mediterranean origin) showed a significant association of the Hp 1-1 phenotype with a higher risk of SCC/Bowen's disease (P = 0.035) and multiple primary SCCs (P = 0.002). No significant difference between the Hp phenotypes was found for the development of Bowen's disease and SCCs in the first 10 years following renal transplantation. However, after a follow-up of {\textrangle}10 years, a significant association between the Hp 1-1 phenotype and the occurrence of Bowen's disease and SCC was reported (P = 0.002 and P = 0.001 respectively).
Conclusions : This study shows an increased risk for the development of (multiple) SCCs in kidney transplant patients with the Hp 1-1 phenotype. This finding points to the role of Hp 1-1 phenotype as an important predictor in identifying a subset of patients with an increased need for preventive measures and is in agreement with the decreased anti-inflammatory capacity of this phenotype.},
  author       = {Speeckaert, Reinhart and Brochez, Lieve and Lambert, Jo and van Geel, Nanja and Speeckaert, Marijn and CLAEYS, LAURENS and Langlois, Michel and Van Laer, C and Peeters, Patrick and Delanghe, Joris},
  issn         = {0926-9959},
  journal      = {JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY},
  language     = {eng},
  number       = {5},
  pages        = {566--571},
  title        = {The haptoglobin phenotype influences the risk of cutaneous squamous cell carcinoma in kidney transplant patients},
  url          = {http://dx.doi.org/10.1111/j.1468-3083.2011.04112.x},
  volume       = {26},
  year         = {2012},
}

Altmetric
View in Altmetric
Web of Science
Times cited: