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The haptoglobin phenotype influences the risk of cutaneous squamous cell carcinoma in kidney transplant patients

Reinhart Speeckaert UGent, Lieve Brochez UGent, Jo Lambert UGent, Nanja van Geel UGent, Marijn Speeckaert UGent, LAURENS CLAEYS UGent, Michel Langlois UGent, C Van Laer, PATRICK PEETERS UGent and Joris Delanghe UGent (2012) JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 26(5). p.566-571
abstract
Background : Cutaneous squamous cell carcinoma (SCC) is the most frequent skin cancer after organ transplantation. Currently, the pre-identification of transplant patients at increased risk for non-melanoma skin cancer remains difficult. Objective : To investigate the Hp polymorphism as a marker for the identification of a subset of patients with an increased susceptibility to develop SCC/Bowen's disease. Methods : Haptoglobin phenotyping was performed with haemoglobin-supplemented starch gel electrophoresis in 300 kidney transplant patients. High-performance gel permeation chromatography was used in case of low serum haptoglobin concentration. Results : Cox regression analysis (adjusted for age, gender and Mediterranean origin) showed a significant association of the Hp 1-1 phenotype with a higher risk of SCC/Bowen's disease (P = 0.035) and multiple primary SCCs (P = 0.002). No significant difference between the Hp phenotypes was found for the development of Bowen's disease and SCCs in the first 10 years following renal transplantation. However, after a follow-up of >10 years, a significant association between the Hp 1-1 phenotype and the occurrence of Bowen's disease and SCC was reported (P = 0.002 and P = 0.001 respectively). Conclusions : This study shows an increased risk for the development of (multiple) SCCs in kidney transplant patients with the Hp 1-1 phenotype. This finding points to the role of Hp 1-1 phenotype as an important predictor in identifying a subset of patients with an increased need for preventive measures and is in agreement with the decreased anti-inflammatory capacity of this phenotype.
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author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
RECIPIENTS, INDIVIDUALS, FREE HEMOGLOBIN, CERVICAL-CANCER, HUMAN-PAPILLOMAVIRUS INFECTION, EPIDERMODYSPLASIA-VERRUCIFORMIS, PREMALIGNANT SKIN-LESIONS, POLYMORPHISM, ASSOCIATION, MULTICENTER
journal title
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
J. Eur. Acad. Dermatol. Venereol.
volume
26
issue
5
pages
566 - 571
Web of Science type
Article
Web of Science id
000303051300005
JCR category
DERMATOLOGY
JCR impact factor
2.694 (2012)
JCR rank
13/58 (2012)
JCR quartile
1 (2012)
ISSN
0926-9959
DOI
10.1111/j.1468-3083.2011.04112.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2117237
handle
http://hdl.handle.net/1854/LU-2117237
date created
2012-05-29 15:33:08
date last changed
2014-05-08 11:07:42
@article{2117237,
  abstract     = {Background : Cutaneous squamous cell carcinoma (SCC) is the most frequent skin cancer after organ transplantation. Currently, the pre-identification of transplant patients at increased risk for non-melanoma skin cancer remains difficult.
Objective : To investigate the Hp polymorphism as a marker for the identification of a subset of patients with an increased susceptibility to develop SCC/Bowen's disease.
Methods : Haptoglobin phenotyping was performed with haemoglobin-supplemented starch gel electrophoresis in 300 kidney transplant patients. High-performance gel permeation chromatography was used in case of low serum haptoglobin concentration.
Results : Cox regression analysis (adjusted for age, gender and Mediterranean origin) showed a significant association of the Hp 1-1 phenotype with a higher risk of SCC/Bowen's disease (P = 0.035) and multiple primary SCCs (P = 0.002). No significant difference between the Hp phenotypes was found for the development of Bowen's disease and SCCs in the first 10 years following renal transplantation. However, after a follow-up of {\textrangle}10 years, a significant association between the Hp 1-1 phenotype and the occurrence of Bowen's disease and SCC was reported (P = 0.002 and P = 0.001 respectively).
Conclusions : This study shows an increased risk for the development of (multiple) SCCs in kidney transplant patients with the Hp 1-1 phenotype. This finding points to the role of Hp 1-1 phenotype as an important predictor in identifying a subset of patients with an increased need for preventive measures and is in agreement with the decreased anti-inflammatory capacity of this phenotype.},
  author       = {Speeckaert, Reinhart and Brochez, Lieve and Lambert, Jo and van Geel, Nanja and Speeckaert, Marijn and CLAEYS, LAURENS and Langlois, Michel and Van Laer, C and PEETERS, PATRICK and Delanghe, Joris},
  issn         = {0926-9959},
  journal      = {JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY},
  keyword      = {RECIPIENTS,INDIVIDUALS,FREE HEMOGLOBIN,CERVICAL-CANCER,HUMAN-PAPILLOMAVIRUS INFECTION,EPIDERMODYSPLASIA-VERRUCIFORMIS,PREMALIGNANT SKIN-LESIONS,POLYMORPHISM,ASSOCIATION,MULTICENTER},
  language     = {eng},
  number       = {5},
  pages        = {566--571},
  title        = {The haptoglobin phenotype influences the risk of cutaneous squamous cell carcinoma in kidney transplant patients},
  url          = {http://dx.doi.org/10.1111/j.1468-3083.2011.04112.x},
  volume       = {26},
  year         = {2012},
}

Chicago
Speeckaert, Reinhart, Lieve Brochez, Jo Lambert, Nanja van Geel, Marijn Speeckaert, LAURENS CLAEYS, Michel Langlois, C Van Laer, PATRICK PEETERS, and Joris Delanghe. 2012. “The Haptoglobin Phenotype Influences the Risk of Cutaneous Squamous Cell Carcinoma in Kidney Transplant Patients.” Journal of the European Academy of Dermatology and Venereology 26 (5): 566–571.
APA
Speeckaert, R., Brochez, L., Lambert, J., van Geel, N., Speeckaert, M., CLAEYS, L., Langlois, M., et al. (2012). The haptoglobin phenotype influences the risk of cutaneous squamous cell carcinoma in kidney transplant patients. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 26(5), 566–571.
Vancouver
1.
Speeckaert R, Brochez L, Lambert J, van Geel N, Speeckaert M, CLAEYS L, et al. The haptoglobin phenotype influences the risk of cutaneous squamous cell carcinoma in kidney transplant patients. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 2012;26(5):566–71.
MLA
Speeckaert, Reinhart, Lieve Brochez, Jo Lambert, et al. “The Haptoglobin Phenotype Influences the Risk of Cutaneous Squamous Cell Carcinoma in Kidney Transplant Patients.” JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 26.5 (2012): 566–571. Print.