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Halo naevi with associated vitiligo-like depigmentations: pathogenetic hypothesis

Nanja van Geel UGent, Reinhart Speeckaert UGent, Jo Lambert UGent, ILSE MOLLET UGent, STEFANIE DE KEYSER UGent, Sofie De Schepper UGent and Lieve Brochez UGent (2011) JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 26(6). p.755-761
abstract
Background : In analogy with melanoma-associated leucoderma, halo naevi may trigger in some patients the development of additional depigmentations which are in distribution, extent and prognosis not in accordance with classic vitiligo. Objective : The aim of this study was to support the hypothesis that in a subset of halo naevi patients vitiligo-like lesions develop directly linked to the halo phenomenon. Methods : Forty-one patients with halo naevi were examined for the development of depigmentations not corresponding to typical vitiligo lesions. Results : We identified a subset of five halo naevi patients with additional subtle depigmentations. After the occurrence of multiple halo naevi, they developed leucoderma that showed a different disease pattern than vitiligo (variable asymmetric distribution, limited extent and lack of progression). Moreover, the characteristics of these halo naevi patients with associated leucoderma were different from classic vitiligo patients (high number of halo naevi, absence of family history for vitiligo and absence of autoimmune diseases) and the timing of occurrence of the leucoderma suggested a direct relation with the halo phenomenon. Conclusions : In this article, we describe in a limited subset of patients with multiple halo naevi discrete depigmentations at distance from halo naevi which may result from a temporary autoimmune process directly linked to the halo phenomenon. This finding illustrates the collateral damage resulting from skin immunosurveillance and may have clinical consequences as the evolution pattern in this subset of patients is less progressive compared with vitiligo. We present clinical data that support this hypothesis and suggest to call it halo naevi-associated leucoderma.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SEGMENTAL VITILIGO, METASTATIC MELANOMA, IMMUNOTHERAPY, LEUKODERMA
journal title
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
J. Eur. Acad. Dermatol. Venereol.
volume
26
issue
6
pages
755 - 761
Web of Science type
Article
Web of Science id
000304397900015
JCR category
DERMATOLOGY
JCR impact factor
2.98 (2011)
JCR rank
11/58 (2011)
JCR quartile
1 (2011)
ISSN
0926-9959
DOI
10.1111/j.1468-3083.2011.04160.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2117229
handle
http://hdl.handle.net/1854/LU-2117229
date created
2012-05-29 15:33:08
date last changed
2012-07-12 09:33:26
@article{2117229,
  abstract     = {Background : In analogy with melanoma-associated leucoderma, halo naevi may trigger in some patients the development of additional depigmentations which are in distribution, extent and prognosis not in accordance with classic vitiligo.
Objective : The aim of this study was to support the hypothesis that in a subset of halo naevi patients vitiligo-like lesions develop directly linked to the halo phenomenon.
Methods : Forty-one patients with halo naevi were examined for the development of depigmentations not corresponding to typical vitiligo lesions.
Results : We identified a subset of five halo naevi patients with additional subtle depigmentations. After the occurrence of multiple halo naevi, they developed leucoderma that showed a different disease pattern than vitiligo (variable asymmetric distribution, limited extent and lack of progression). Moreover, the characteristics of these halo naevi patients with associated leucoderma were different from classic vitiligo patients (high number of halo naevi, absence of family history for vitiligo and absence of autoimmune diseases) and the timing of occurrence of the leucoderma suggested a direct relation with the halo phenomenon.
Conclusions : In this article, we describe in a limited subset of patients with multiple halo naevi discrete depigmentations at distance from halo naevi which may result from a temporary autoimmune process directly linked to the halo phenomenon. This finding illustrates the collateral damage resulting from skin immunosurveillance and may have clinical consequences as the evolution pattern in this subset of patients is less progressive compared with vitiligo. We present clinical data that support this hypothesis and suggest to call it halo naevi-associated leucoderma.},
  author       = {van Geel, Nanja and Speeckaert, Reinhart and Lambert, Jo and MOLLET, ILSE and DE KEYSER, STEFANIE and De Schepper, Sofie and Brochez, Lieve},
  issn         = {0926-9959},
  journal      = {JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY},
  keyword      = {SEGMENTAL VITILIGO,METASTATIC MELANOMA,IMMUNOTHERAPY,LEUKODERMA},
  language     = {eng},
  number       = {6},
  pages        = {755--761},
  title        = {Halo naevi with associated vitiligo-like depigmentations: pathogenetic hypothesis},
  url          = {http://dx.doi.org/10.1111/j.1468-3083.2011.04160.x},
  volume       = {26},
  year         = {2011},
}

Chicago
van Geel, Nanja, Reinhart Speeckaert, Jo Lambert, ILSE MOLLET, STEFANIE DE KEYSER, Sofie De Schepper, and Lieve Brochez. 2011. “Halo Naevi with Associated Vitiligo-like Depigmentations: Pathogenetic Hypothesis.” Journal of the European Academy of Dermatology and Venereology 26 (6): 755–761.
APA
van Geel, N., Speeckaert, R., Lambert, J., MOLLET, I., DE KEYSER, S., De Schepper, S., & Brochez, L. (2011). Halo naevi with associated vitiligo-like depigmentations: pathogenetic hypothesis. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 26(6), 755–761.
Vancouver
1.
van Geel N, Speeckaert R, Lambert J, MOLLET I, DE KEYSER S, De Schepper S, et al. Halo naevi with associated vitiligo-like depigmentations: pathogenetic hypothesis. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 2011;26(6):755–61.
MLA
van Geel, Nanja, Reinhart Speeckaert, Jo Lambert, et al. “Halo Naevi with Associated Vitiligo-like Depigmentations: Pathogenetic Hypothesis.” JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 26.6 (2011): 755–761. Print.