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Halo naevi with associated vitiligo-like depigmentations: pathogenetic hypothesis

Nanja van Geel (UGent) , Reinhart Speeckaert (UGent) , Jo Lambert (UGent) , ILSE MOLLET (UGent) , Stefanie De Keyser (UGent) , Sofie De Schepper (UGent) and Lieve Brochez (UGent)
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Abstract
Background : In analogy with melanoma-associated leucoderma, halo naevi may trigger in some patients the development of additional depigmentations which are in distribution, extent and prognosis not in accordance with classic vitiligo. Objective : The aim of this study was to support the hypothesis that in a subset of halo naevi patients vitiligo-like lesions develop directly linked to the halo phenomenon. Methods : Forty-one patients with halo naevi were examined for the development of depigmentations not corresponding to typical vitiligo lesions. Results : We identified a subset of five halo naevi patients with additional subtle depigmentations. After the occurrence of multiple halo naevi, they developed leucoderma that showed a different disease pattern than vitiligo (variable asymmetric distribution, limited extent and lack of progression). Moreover, the characteristics of these halo naevi patients with associated leucoderma were different from classic vitiligo patients (high number of halo naevi, absence of family history for vitiligo and absence of autoimmune diseases) and the timing of occurrence of the leucoderma suggested a direct relation with the halo phenomenon. Conclusions : In this article, we describe in a limited subset of patients with multiple halo naevi discrete depigmentations at distance from halo naevi which may result from a temporary autoimmune process directly linked to the halo phenomenon. This finding illustrates the collateral damage resulting from skin immunosurveillance and may have clinical consequences as the evolution pattern in this subset of patients is less progressive compared with vitiligo. We present clinical data that support this hypothesis and suggest to call it halo naevi-associated leucoderma.
Keywords
SEGMENTAL VITILIGO, METASTATIC MELANOMA, IMMUNOTHERAPY, LEUKODERMA

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Chicago
van Geel, Nanja, Reinhart Speeckaert, Jo Lambert, ILSE MOLLET, Stefanie De Keyser, Sofie De Schepper, and Lieve Brochez. 2011. “Halo Naevi with Associated Vitiligo-like Depigmentations: Pathogenetic Hypothesis.” Journal of the European Academy of Dermatology and Venereology 26 (6): 755–761.
APA
van Geel, N., Speeckaert, R., Lambert, J., MOLLET, I., De Keyser, S., De Schepper, S., & Brochez, L. (2011). Halo naevi with associated vitiligo-like depigmentations: pathogenetic hypothesis. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 26(6), 755–761.
Vancouver
1.
van Geel N, Speeckaert R, Lambert J, MOLLET I, De Keyser S, De Schepper S, et al. Halo naevi with associated vitiligo-like depigmentations: pathogenetic hypothesis. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 2011;26(6):755–61.
MLA
van Geel, Nanja, Reinhart Speeckaert, Jo Lambert, et al. “Halo Naevi with Associated Vitiligo-like Depigmentations: Pathogenetic Hypothesis.” JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 26.6 (2011): 755–761. Print.
@article{2117229,
  abstract     = {Background : In analogy with melanoma-associated leucoderma, halo naevi may trigger in some patients the development of additional depigmentations which are in distribution, extent and prognosis not in accordance with classic vitiligo.
Objective : The aim of this study was to support the hypothesis that in a subset of halo naevi patients vitiligo-like lesions develop directly linked to the halo phenomenon.
Methods : Forty-one patients with halo naevi were examined for the development of depigmentations not corresponding to typical vitiligo lesions.
Results : We identified a subset of five halo naevi patients with additional subtle depigmentations. After the occurrence of multiple halo naevi, they developed leucoderma that showed a different disease pattern than vitiligo (variable asymmetric distribution, limited extent and lack of progression). Moreover, the characteristics of these halo naevi patients with associated leucoderma were different from classic vitiligo patients (high number of halo naevi, absence of family history for vitiligo and absence of autoimmune diseases) and the timing of occurrence of the leucoderma suggested a direct relation with the halo phenomenon.
Conclusions : In this article, we describe in a limited subset of patients with multiple halo naevi discrete depigmentations at distance from halo naevi which may result from a temporary autoimmune process directly linked to the halo phenomenon. This finding illustrates the collateral damage resulting from skin immunosurveillance and may have clinical consequences as the evolution pattern in this subset of patients is less progressive compared with vitiligo. We present clinical data that support this hypothesis and suggest to call it halo naevi-associated leucoderma.},
  author       = {van Geel, Nanja and Speeckaert, Reinhart and Lambert, Jo and MOLLET, ILSE and De Keyser, Stefanie and De Schepper, Sofie and Brochez, Lieve},
  issn         = {0926-9959},
  journal      = {JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY},
  language     = {eng},
  number       = {6},
  pages        = {755--761},
  title        = {Halo naevi with associated vitiligo-like depigmentations: pathogenetic hypothesis},
  url          = {http://dx.doi.org/10.1111/j.1468-3083.2011.04160.x},
  volume       = {26},
  year         = {2011},
}

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