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New insights in segmental vitiligo: case report and review of theories

Nanja van Geel (UGent) , ILSE MOLLET (UGent) , Lieve Brochez (UGent) , MARIEKE DUTRE, Sofie De Schepper (UGent) , Evelien Verhaeghe (UGent) , Jo Lambert (UGent) and Reinhart Speeckaert (UGent)
(2012) BRITISH JOURNAL OF DERMATOLOGY. 166(2). p.240-246
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Abstract
Segmental vitiligo and generalized vitiligo are in general considered to be separate entities. The aetiopathogenesis of segmental vitiligo remains unclear, although several hypotheses have been put forward including mainly neuronal mechanisms. The typical association with other autoimmune diseases, as seen in generalized vitiligo, seems to be significantly less in segmental vitiligo, although recent insights point towards a possible immune-mediated overlap between the two subtypes. In this article, we describe a case with simultaneous presence of segmental vitiligo, alopecia areata, psoriasis and a halo naevus. To our knowledge, this is the first case with this exceptional combination. This concomitant presence could support the involvement of a shared autoimmune-mediated process, and may provide new insights into the pathogenesis of segmental vitiligo and direct future research. In the light of this remarkable case, different possible aetiopathogenetic mechanisms leading to the clinical presentation of segmental vitiligo are discussed and a new three-step theory is proposed.
Keywords
MOSAICISM, Vitiligo, PSORIASIS, MELANOCYTES, DESTRUCTION, LESIONS, NEUROPEPTIDES, SKIN, T-CELLS, HALO NEVI, etiology, immunology, ALOPECIA-AREATA

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Chicago
van Geel, Nanja, ILSE MOLLET, Lieve Brochez, MARIEKE DUTRE, Sofie De Schepper, Evelien Verhaeghe, Jo Lambert, and Reinhart Speeckaert. 2012. “New Insights in Segmental Vitiligo: Case Report and Review of Theories.” British Journal of Dermatology 166 (2): 240–246.
APA
van Geel, N., MOLLET, I., Brochez, L., DUTRE, M., De Schepper, S., Verhaeghe, E., Lambert, J., et al. (2012). New insights in segmental vitiligo: case report and review of theories. BRITISH JOURNAL OF DERMATOLOGY, 166(2), 240–246.
Vancouver
1.
van Geel N, MOLLET I, Brochez L, DUTRE M, De Schepper S, Verhaeghe E, et al. New insights in segmental vitiligo: case report and review of theories. BRITISH JOURNAL OF DERMATOLOGY. 2012;166(2):240–6.
MLA
van Geel, Nanja, ILSE MOLLET, Lieve Brochez, et al. “New Insights in Segmental Vitiligo: Case Report and Review of Theories.” BRITISH JOURNAL OF DERMATOLOGY 166.2 (2012): 240–246. Print.
@article{2117216,
  abstract     = {Segmental vitiligo and generalized vitiligo are in general considered to be separate entities. The aetiopathogenesis of segmental vitiligo remains unclear, although several hypotheses have been put forward including mainly neuronal mechanisms. The typical association with other autoimmune diseases, as seen in generalized vitiligo, seems to be significantly less in segmental vitiligo, although recent insights point towards a possible immune-mediated overlap between the two subtypes. In this article, we describe a case with simultaneous presence of segmental vitiligo, alopecia areata, psoriasis and a halo naevus. To our knowledge, this is the first case with this exceptional combination. This concomitant presence could support the involvement of a shared autoimmune-mediated process, and may provide new insights into the pathogenesis of segmental vitiligo and direct future research. In the light of this remarkable case, different possible aetiopathogenetic mechanisms leading to the clinical presentation of segmental vitiligo are discussed and a new three-step theory is proposed.},
  author       = {van Geel, Nanja and MOLLET, ILSE and Brochez, Lieve and DUTRE, MARIEKE and De Schepper, Sofie and Verhaeghe, Evelien and Lambert, Jo and Speeckaert, Reinhart},
  issn         = {0007-0963},
  journal      = {BRITISH JOURNAL OF DERMATOLOGY},
  keyword      = {MOSAICISM,Vitiligo,PSORIASIS,MELANOCYTES,DESTRUCTION,LESIONS,NEUROPEPTIDES,SKIN,T-CELLS,HALO NEVI,etiology,immunology,ALOPECIA-AREATA},
  language     = {eng},
  number       = {2},
  pages        = {240--246},
  title        = {New insights in segmental vitiligo: case report and review of theories},
  url          = {http://dx.doi.org/10.1111/j.1365-2133.2011.10650.x},
  volume       = {166},
  year         = {2012},
}

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