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New insights in segmental vitiligo: case report and review of theories

Nanja van Geel UGent, ILSE MOLLET UGent, Lieve Brochez UGent, MARIEKE DUTRE UGent, Sofie De Schepper UGent, EVELIEN VERHAEGHE UGent, Jo Lambert UGent and Reinhart Speeckaert UGent (2012) BRITISH JOURNAL OF DERMATOLOGY. 166(2). p.240-246
abstract
Segmental vitiligo and generalized vitiligo are in general considered to be separate entities. The aetiopathogenesis of segmental vitiligo remains unclear, although several hypotheses have been put forward including mainly neuronal mechanisms. The typical association with other autoimmune diseases, as seen in generalized vitiligo, seems to be significantly less in segmental vitiligo, although recent insights point towards a possible immune-mediated overlap between the two subtypes. In this article, we describe a case with simultaneous presence of segmental vitiligo, alopecia areata, psoriasis and a halo naevus. To our knowledge, this is the first case with this exceptional combination. This concomitant presence could support the involvement of a shared autoimmune-mediated process, and may provide new insights into the pathogenesis of segmental vitiligo and direct future research. In the light of this remarkable case, different possible aetiopathogenetic mechanisms leading to the clinical presentation of segmental vitiligo are discussed and a new three-step theory is proposed.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
MOSAICISM, Vitiligo, PSORIASIS, MELANOCYTES, DESTRUCTION, LESIONS, NEUROPEPTIDES, SKIN, T-CELLS, HALO NEVI, etiology, immunology, ALOPECIA-AREATA
journal title
BRITISH JOURNAL OF DERMATOLOGY
Br. J. Dermatol.
volume
166
issue
2
pages
240 - 246
Web of Science type
Review
Web of Science id
000300699200004
JCR category
DERMATOLOGY
JCR impact factor
3.759 (2012)
JCR rank
5/58 (2012)
JCR quartile
1 (2012)
ISSN
0007-0963
DOI
10.1111/j.1365-2133.2011.10650.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2117216
handle
http://hdl.handle.net/1854/LU-2117216
date created
2012-05-29 15:33:08
date last changed
2012-07-12 09:43:49
@article{2117216,
  abstract     = {Segmental vitiligo and generalized vitiligo are in general considered to be separate entities. The aetiopathogenesis of segmental vitiligo remains unclear, although several hypotheses have been put forward including mainly neuronal mechanisms. The typical association with other autoimmune diseases, as seen in generalized vitiligo, seems to be significantly less in segmental vitiligo, although recent insights point towards a possible immune-mediated overlap between the two subtypes. In this article, we describe a case with simultaneous presence of segmental vitiligo, alopecia areata, psoriasis and a halo naevus. To our knowledge, this is the first case with this exceptional combination. This concomitant presence could support the involvement of a shared autoimmune-mediated process, and may provide new insights into the pathogenesis of segmental vitiligo and direct future research. In the light of this remarkable case, different possible aetiopathogenetic mechanisms leading to the clinical presentation of segmental vitiligo are discussed and a new three-step theory is proposed.},
  author       = {van Geel, Nanja and MOLLET, ILSE and Brochez, Lieve and DUTRE, MARIEKE and De Schepper, Sofie and VERHAEGHE, EVELIEN and Lambert, Jo and Speeckaert, Reinhart},
  issn         = {0007-0963},
  journal      = {BRITISH JOURNAL OF DERMATOLOGY},
  keyword      = {MOSAICISM,Vitiligo,PSORIASIS,MELANOCYTES,DESTRUCTION,LESIONS,NEUROPEPTIDES,SKIN,T-CELLS,HALO NEVI,etiology,immunology,ALOPECIA-AREATA},
  language     = {eng},
  number       = {2},
  pages        = {240--246},
  title        = {New insights in segmental vitiligo: case report and review of theories},
  url          = {http://dx.doi.org/10.1111/j.1365-2133.2011.10650.x},
  volume       = {166},
  year         = {2012},
}

Chicago
van Geel, Nanja, ILSE MOLLET, Lieve Brochez, MARIEKE DUTRE, Sofie De Schepper, Evelien Verhaeghe, Jo Lambert, and Reinhart Speeckaert. 2012. “New Insights in Segmental Vitiligo: Case Report and Review of Theories.” British Journal of Dermatology 166 (2): 240–246.
APA
van Geel, N., MOLLET, I., Brochez, L., DUTRE, M., De Schepper, S., Verhaeghe, E., Lambert, J., et al. (2012). New insights in segmental vitiligo: case report and review of theories. BRITISH JOURNAL OF DERMATOLOGY, 166(2), 240–246.
Vancouver
1.
van Geel N, MOLLET I, Brochez L, DUTRE M, De Schepper S, Verhaeghe E, et al. New insights in segmental vitiligo: case report and review of theories. BRITISH JOURNAL OF DERMATOLOGY. 2012;166(2):240–6.
MLA
van Geel, Nanja, ILSE MOLLET, Lieve Brochez, et al. “New Insights in Segmental Vitiligo: Case Report and Review of Theories.” BRITISH JOURNAL OF DERMATOLOGY 166.2 (2012): 240–246. Print.