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Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo

(2012) NATURE GENETICS. 44(6). p.676-680
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Abstract
We previously reported a genome-wide association study (GWAS) identifying 14 susceptibility loci for generalized vitiligo. We report here a second GWAS (450 individuals with vitiligo (cases) and 3,182 controls), an independent replication study (1,440 cases and 1,316 controls) and a meta-analysis (3,187 cases and 6,723 controls) identifying 13 additional vitiligo-associated loci. These include OCA2-HERC2 (combined P = 3.80 x 10(-8)), MC1R (P = 1.82 x 10(-13)), a region near TYR (P = 1.57 x 10(-13)), IFIH1 (P = 4.91 x 10(-15)), CD80 (P = 3.78 x 10(-10)), CLNK (P = 1.56 x 10(-8)), BACH2 (P = 2.53 x 10(-8)), SLA (P = 1.58 x 10(-8)), CASP7 (P = 3.56 x 10(-8)), CD44 (P = 1.78 x 10(-9)), IKZF4 (P = 2.75 x 10(-14)), SH2B3 (P = 3.54 x 10(-18)) and TOB2 (P = 6.81 x 10(-10)). Most vitiligo susceptibility loci encode immunoregulatory proteins or melanocyte components that likely mediate immune targeting and the relationships among vitiligo, melanoma, and eye, skin and hair coloration.
Keywords
COMMON VARIANTS, MULTIPLE-SCLEROSIS, RHEUMATOID-ARTHRITIS, CELIAC-DISEASE, EYED-DILUTION LOCUS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, IRIS COLOR, RISK LOCI, GENE, IMMUNE

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Chicago
Jin, Ying, Stanca A Birlea, Pamela R Fain, Tracey M Ferrara, Songtao Ben, Sheri L Riccardi, Joanne B Cole, et al. 2012. “Genome-wide Association Analyses Identify 13 New Susceptibility Loci for Generalized Vitiligo.” Nature Genetics 44 (6): 676–680.
APA
Jin, Ying, Birlea, S. A., Fain, P. R., Ferrara, T. M., Ben, S., Riccardi, S. L., Cole, J. B., et al. (2012). Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. NATURE GENETICS, 44(6), 676–680.
Vancouver
1.
Jin Y, Birlea SA, Fain PR, Ferrara TM, Ben S, Riccardi SL, et al. Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. NATURE GENETICS. 2012;44(6):676–80.
MLA
Jin, Ying, Stanca A Birlea, Pamela R Fain, et al. “Genome-wide Association Analyses Identify 13 New Susceptibility Loci for Generalized Vitiligo.” NATURE GENETICS 44.6 (2012): 676–680. Print.
@article{2117123,
  abstract     = {We previously reported a genome-wide association study (GWAS) identifying 14 susceptibility loci for generalized vitiligo. We report here a second GWAS (450 individuals with vitiligo (cases) and 3,182 controls), an independent replication study (1,440 cases and 1,316 controls) and a meta-analysis (3,187 cases and 6,723 controls) identifying 13 additional vitiligo-associated loci. These include OCA2-HERC2 (combined P = 3.80 x 10(-8)), MC1R (P = 1.82 x 10(-13)), a region near TYR (P = 1.57 x 10(-13)), IFIH1 (P = 4.91 x 10(-15)), CD80 (P = 3.78 x 10(-10)), CLNK (P = 1.56 x 10(-8)), BACH2 (P = 2.53 x 10(-8)), SLA (P = 1.58 x 10(-8)), CASP7 (P = 3.56 x 10(-8)), CD44 (P = 1.78 x 10(-9)), IKZF4 (P = 2.75 x 10(-14)), SH2B3 (P = 3.54 x 10(-18)) and TOB2 (P = 6.81 x 10(-10)). Most vitiligo susceptibility loci encode immunoregulatory proteins or melanocyte components that likely mediate immune targeting and the relationships among vitiligo, melanoma, and eye, skin and hair coloration.},
  author       = {Jin, Ying and Birlea, Stanca A and Fain, Pamela R and Ferrara, Tracey M and Ben, Songtao and Riccardi, Sheri L and Cole, Joanne B and Gowan, Katherine and Holland, Paulene J and Bennett, Dorothy C and Luiten, Rosalie M and Wolkerstorfer, Albert and van der Veen, JP Wietze and Hartmann, Anke and Eichner, Saskia and Schuler, Gerold and van Geel, Nanja and Lambert, Jo and Kemp, E Helen and Gawkrodger, David J and Weetman, Anthony P and Ta{\"i}eb, Alain and Jouary, Thomas and Ezzedine, Khaled and Wallace, Margaret R and McCormack, Wayne T and Picardo, Mauro and Leone, Giovanni and Overbeck, Andreas and Silverberg, Nanette B and Spritz, Richard A},
  issn         = {1061-4036},
  journal      = {NATURE GENETICS},
  keyword      = {COMMON VARIANTS,MULTIPLE-SCLEROSIS,RHEUMATOID-ARTHRITIS,CELIAC-DISEASE,EYED-DILUTION LOCUS,SYSTEMIC-LUPUS-ERYTHEMATOSUS,IRIS COLOR,RISK LOCI,GENE,IMMUNE},
  language     = {eng},
  number       = {6},
  pages        = {676--680},
  title        = {Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo},
  url          = {http://dx.doi.org/10.1038/ng.2272},
  volume       = {44},
  year         = {2012},
}

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