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Validated measurements of the uranium isotopic signature in human urine samples using magnetic sector-field inductively coupled plasma mass spectrometry

Ivan Trešl, Günther De Wannemacker, Christophe R Quétel, Ivan Petrov, Frank Vanhaecke UGent, Luc Moens UGent and Philip DP Taylor (2004) ENVIRONMENTAL SCIENCE & TECHNOLOGY. 38(2). p.581-586
abstract
Increased interest in measuring uranium isotope ratios in environmental samples (biological materials, soils, dust particles, water) has come from the necessity to assess the health impact of the use of depleted uranium (DU) based ammunitions during recent military conflicts (e.g., Gulf war, Kosovo) and from the need to identify nondeclared nuclear activities (nuclear safeguards). In this context, very important decisions can arise which have to be based on measurement data of nondisputable uncertainty. The present study describes the certification to 2.5% (k = 2) relative combined uncertainty of n((235)U)/n((238)U) at ultralow uranium levels (similar to5-20 pg g(-1)) in human urine samples. After sample decomposition and matrix separation, the isotope ratios were measured by means of a single-detector magnetic sector-field inductively coupled plasma mass spectrometry instrument fitted with an ultrasonic nebulizer. Correction for mass discrimination effects was obtained by means of the certified isotopic reference material IRMM-184. The analytical procedure developed was validated in three complementary ways. First, all major sources of uncertainty were identified and propagated together following the ISO/GUM guidelines. Second, this quality was controlled with a matrix matching NUSIMEP-3 sample (similar to0.06-0.7% difference from certified). Third, the instrumental part of the procedure was proven to be reproducible from the confirmation of the results obtained for three samples remeasured 7 months later (similar to1.5% difference). The results obtained for 33 individuals indicated that none seemed to have been exposed to contamination by DU.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ICP-MS, DETERMINING PICOGRAM QUANTITIES, DEPLETED URANIUM, ALPHA-SPECTROMETRY, RATIOS
journal title
ENVIRONMENTAL SCIENCE & TECHNOLOGY
Environ. Sci. Technol.
volume
38
issue
2
pages
581 - 586
Web of Science type
Article
Web of Science id
000188124800036
JCR category
ENVIRONMENTAL SCIENCES
JCR impact factor
3.557 (2004)
JCR rank
4/133 (2004)
JCR quartile
1 (2004)
ISSN
0013-936X
DOI
10.1021/es0346025
language
English
UGent publication?
yes
classification
A1
id
211616
handle
http://hdl.handle.net/1854/LU-211616
date created
2004-04-19 15:12:00
date last changed
2012-11-12 15:37:44
@article{211616,
  abstract     = {Increased interest in measuring uranium isotope ratios in environmental samples (biological materials, soils, dust particles, water) has come from the necessity to assess the health impact of the use of depleted uranium (DU) based ammunitions during recent military conflicts (e.g., Gulf war, Kosovo) and from the need to identify nondeclared nuclear activities (nuclear safeguards). In this context, very important decisions can arise which have to be based on measurement data of nondisputable uncertainty. The present study describes the certification to 2.5\% (k = 2) relative combined uncertainty of n((235)U)/n((238)U) at ultralow uranium levels (similar to5-20 pg g(-1)) in human urine samples. After sample decomposition and matrix separation, the isotope ratios were measured by means of a single-detector magnetic sector-field inductively coupled plasma mass spectrometry instrument fitted with an ultrasonic nebulizer. Correction for mass discrimination effects was obtained by means of the certified isotopic reference material IRMM-184. The analytical procedure developed was validated in three complementary ways. First, all major sources of uncertainty were identified and propagated together following the ISO/GUM guidelines. Second, this quality was controlled with a matrix matching NUSIMEP-3 sample (similar to0.06-0.7\% difference from certified). Third, the instrumental part of the procedure was proven to be reproducible from the confirmation of the results obtained for three samples remeasured 7 months later (similar to1.5\% difference). The results obtained for 33 individuals indicated that none seemed to have been exposed to contamination by DU.},
  author       = {Tre\v{s}l, Ivan and De Wannemacker, G{\"u}nther and Qu{\'e}tel, Christophe R and Petrov, Ivan and Vanhaecke, Frank and Moens, Luc and Taylor, Philip DP},
  issn         = {0013-936X},
  journal      = {ENVIRONMENTAL SCIENCE \& TECHNOLOGY},
  keyword      = {ICP-MS,DETERMINING PICOGRAM QUANTITIES,DEPLETED URANIUM,ALPHA-SPECTROMETRY,RATIOS},
  language     = {eng},
  number       = {2},
  pages        = {581--586},
  title        = {Validated measurements of the uranium isotopic signature in human urine samples using magnetic sector-field inductively coupled plasma mass spectrometry},
  url          = {http://dx.doi.org/10.1021/es0346025},
  volume       = {38},
  year         = {2004},
}

Chicago
Trešl, Ivan, Günther De Wannemacker, Christophe R Quétel, Ivan Petrov, Frank Vanhaecke, Luc Moens, and Philip DP Taylor. 2004. “Validated Measurements of the Uranium Isotopic Signature in Human Urine Samples Using Magnetic Sector-field Inductively Coupled Plasma Mass Spectrometry.” Environmental Science & Technology 38 (2): 581–586.
APA
Trešl, I., De Wannemacker, G., Quétel, C. R., Petrov, I., Vanhaecke, F., Moens, L., & Taylor, P. D. (2004). Validated measurements of the uranium isotopic signature in human urine samples using magnetic sector-field inductively coupled plasma mass spectrometry. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 38(2), 581–586.
Vancouver
1.
Trešl I, De Wannemacker G, Quétel CR, Petrov I, Vanhaecke F, Moens L, et al. Validated measurements of the uranium isotopic signature in human urine samples using magnetic sector-field inductively coupled plasma mass spectrometry. ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2004;38(2):581–6.
MLA
Trešl, Ivan, Günther De Wannemacker, Christophe R Quétel, et al. “Validated Measurements of the Uranium Isotopic Signature in Human Urine Samples Using Magnetic Sector-field Inductively Coupled Plasma Mass Spectrometry.” ENVIRONMENTAL SCIENCE & TECHNOLOGY 38.2 (2004): 581–586. Print.