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Overcoming spectral overlap in isotopic analysis via single- and multi-collector ICP-mass spectrometry

Frank Vanhaecke UGent and Luc Moens UGent (2004) ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 378(2). p.232-240
abstract
For isotope ratio applications where an internal isotope ratio precision >0.05-0.1% relative standard deviation suffices, single-collector inductively coupled plasma mass spectrometry (ICPMS) is fit-for-purpose, but for detecting more subtle variations in the natural isotopic composition of a target element, only multi-collector ICPMS (MC-ICPMS) can compete with thermal ionization mass spectrometry (TIMS). While as a result of the extensive sample preparation (analyte isolation) preceding TIMS and the 'softer' ionization in vacuum, spectral interferences only seldom occur with this technique, their occurrence is recognized to be the most important drawback of ICPMS. This paper discusses high mass resolution and chemical resolution in a collision or dynamic reaction cell as powerful and versatile means to overcome spectral overlap and illustrates how their introduction has led to a substantial extension of the application range of ICPMS for isotope ratio applications. High mass resolution is the most elegant and straightforward way to overcome the problem of spectral overlap. Offering the possibility to operate the mass analyzer at a higher mass resolution, while at the same time preserving the flat-topped or trapezoidal peak shape required for highly precise isotope ratio measurements, was a challenge for the manufacturers of MC-ICPMS instrumentation. It will be discussed how these apparently contradicting requirements could be fulfilled simultaneously and an overview of the current situation will be given. Chemical resolution in a collision or dynamic reaction cell is an alternative to high mass resolution for overcoming spectral overlap. Real-life examples will be given to illustrate how also this approach can be used to advantage in isotope ratio work. Despite the greater flexibility and straightforwardness of high mass resolution, some situations will be discussed where chemical resolution is to be preferred. Finally, some desires as to future instrumentation are formulated.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
DYNAMIC REACTION CELL, INDUCTIVELY-COUPLED PLASMA, HEXAPOLE COLLISION CELL, DETECTOR DEAD-TIME, RATIO MEASUREMENTS, ACCURATE DETERMINATION, ISOBARIC INTERFERENCES, TOTAL ZINC, MS, RESOLUTION
journal title
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Anal. Bioanal. Chem.
volume
378
issue
2
pages
232 - 240
Web of Science type
Review
Web of Science id
000188112700003
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
2.098 (2004)
JCR rank
20/70 (2004)
JCR quartile
2 (2004)
ISSN
1618-2642
DOI
10.1007/s00216-003-2175-8
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
211615
handle
http://hdl.handle.net/1854/LU-211615
date created
2004-04-19 15:11:00
date last changed
2012-11-12 15:28:42
@article{211615,
  abstract     = {For isotope ratio applications where an internal isotope ratio precision {\textrangle}0.05-0.1\% relative standard deviation suffices, single-collector inductively coupled plasma mass spectrometry (ICPMS) is fit-for-purpose, but for detecting more subtle variations in the natural isotopic composition of a target element, only multi-collector ICPMS (MC-ICPMS) can compete with thermal ionization mass spectrometry (TIMS). While as a result of the extensive sample preparation (analyte isolation) preceding TIMS and the 'softer' ionization in vacuum, spectral interferences only seldom occur with this technique, their occurrence is recognized to be the most important drawback of ICPMS. This paper discusses high mass resolution and chemical resolution in a collision or dynamic reaction cell as powerful and versatile means to overcome spectral overlap and illustrates how their introduction has led to a substantial extension of the application range of ICPMS for isotope ratio applications. High mass resolution is the most elegant and straightforward way to overcome the problem of spectral overlap. Offering the possibility to operate the mass analyzer at a higher mass resolution, while at the same time preserving the flat-topped or trapezoidal peak shape required for highly precise isotope ratio measurements, was a challenge for the manufacturers of MC-ICPMS instrumentation. It will be discussed how these apparently contradicting requirements could be fulfilled simultaneously and an overview of the current situation will be given. Chemical resolution in a collision or dynamic reaction cell is an alternative to high mass resolution for overcoming spectral overlap. Real-life examples will be given to illustrate how also this approach can be used to advantage in isotope ratio work. Despite the greater flexibility and straightforwardness of high mass resolution, some situations will be discussed where chemical resolution is to be preferred. Finally, some desires as to future instrumentation are formulated.},
  author       = {Vanhaecke, Frank and Moens, Luc},
  issn         = {1618-2642},
  journal      = {ANALYTICAL AND BIOANALYTICAL CHEMISTRY},
  keyword      = {DYNAMIC REACTION CELL,INDUCTIVELY-COUPLED PLASMA,HEXAPOLE COLLISION CELL,DETECTOR DEAD-TIME,RATIO MEASUREMENTS,ACCURATE DETERMINATION,ISOBARIC INTERFERENCES,TOTAL ZINC,MS,RESOLUTION},
  language     = {eng},
  number       = {2},
  pages        = {232--240},
  title        = {Overcoming spectral overlap in isotopic analysis via single- and multi-collector ICP-mass spectrometry},
  url          = {http://dx.doi.org/10.1007/s00216-003-2175-8},
  volume       = {378},
  year         = {2004},
}

Chicago
Vanhaecke, Frank, and Luc Moens. 2004. “Overcoming Spectral Overlap in Isotopic Analysis via Single- and Multi-collector ICP-mass Spectrometry.” Analytical and Bioanalytical Chemistry 378 (2): 232–240.
APA
Vanhaecke, Frank, & Moens, L. (2004). Overcoming spectral overlap in isotopic analysis via single- and multi-collector ICP-mass spectrometry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 378(2), 232–240.
Vancouver
1.
Vanhaecke F, Moens L. Overcoming spectral overlap in isotopic analysis via single- and multi-collector ICP-mass spectrometry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2004;378(2):232–40.
MLA
Vanhaecke, Frank, and Luc Moens. “Overcoming Spectral Overlap in Isotopic Analysis via Single- and Multi-collector ICP-mass Spectrometry.” ANALYTICAL AND BIOANALYTICAL CHEMISTRY 378.2 (2004): 232–240. Print.