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Optimisation of ICP-dynamic reaction cell-MS as specific detector for the speciation analysis of vanadium at therapeutic levels in serum

Cyrille C Chéry, Koen De Cremer, Rita Cornelis UGent, Frank Vanhaecke UGent and Luc Moens UGent (2003) JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY. 18(9). p.1113-1118
abstract
Dynamic reaction cell (DRC) technology was applied in the context of the speciation analysis of vanadium at therapeutic levels in serum. This technology was necessary in order to detect vanadium on-line after size-exclusion chromatography with a buffer at physiological salinity (0.15 M NaCl). This salinity was compulsory to assure the stability of the vanadium compounds during chromatography, in other words to prevent interspecies conversion. In fact, the DRC allowed the detection of vanadium without adapting the conditions of the chromatographic separation to ICP-MS. First, the merits of various reaction gases were compared: methane, carbon monoxide, ammonia, oxygen and the combination of argon ( collision gas) and hydrogen ( reaction gas). In each instance, the reaction cell parameters were optimised in order to obtain the lowest detection limit for V-51 (as V-51(+) or as (VO+)-V-51-O-16 with O-2 as the reaction gas) in chlorine-rich solution, Cl being the parent element of the (ClO+)-Cl-35-O-16 interference. Ammonia was found to offer the best detection limit (3s criterion, 10 ng L-1 with pneumatic nebulisation as the sample introduction system). The detection limit with size-exclusion chromatography-ICP-DRC-MS for vanadate, expected to be the worst among all vanadium chemical species, was found to be 40 ng L-1 serum (or 4 pg V, 100 muL serum injected) and the repeatability 7%. This on-line separation method was used in order to speciate vanadium in serum after incubation with vanadate, at a concentration level that is representative of the pharmacological concentration range of vanadium when used as an insulin-like agent.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (proceedingsPaper)
publication status
published
subject
keyword
TRACE-ELEMENTS, IONIZATION-ENERGY, IN-VIVO, RECOMMENDATIONS, SPECTRUM, PATTERNS, CLO, RAT
journal title
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
J. Anal. At. Spectrom.
volume
18
issue
9
pages
1113 - 1118
conference name
European winter conference on Plasma Spectrochemistry
conference location
Garmisch-Partenkirchen, Germany
conference start
2003-01-12
conference end
2003-01-17
Web of Science type
Article
Web of Science id
000185089600020
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
3.2 (2003)
JCR rank
6/67 (2003)
JCR quartile
1 (2003)
ISSN
0267-9477
DOI
10.1039/b301682j
language
English
UGent publication?
yes
classification
A1
id
211477
handle
http://hdl.handle.net/1854/LU-211477
date created
2004-04-19 10:38:00
date last changed
2012-11-12 16:40:30
@article{211477,
  abstract     = {Dynamic reaction cell (DRC) technology was applied in the context of the speciation analysis of vanadium at therapeutic levels in serum. This technology was necessary in order to detect vanadium on-line after size-exclusion chromatography with a buffer at physiological salinity (0.15 M NaCl). This salinity was compulsory to assure the stability of the vanadium compounds during chromatography, in other words to prevent interspecies conversion. In fact, the DRC allowed the detection of vanadium without adapting the conditions of the chromatographic separation to ICP-MS. First, the merits of various reaction gases were compared: methane, carbon monoxide, ammonia, oxygen and the combination of argon ( collision gas) and hydrogen ( reaction gas). In each instance, the reaction cell parameters were optimised in order to obtain the lowest detection limit for V-51 (as V-51(+) or as (VO+)-V-51-O-16 with O-2 as the reaction gas) in chlorine-rich solution, Cl being the parent element of the (ClO+)-Cl-35-O-16 interference. Ammonia was found to offer the best detection limit (3s criterion, 10 ng L-1 with pneumatic nebulisation as the sample introduction system). The detection limit with size-exclusion chromatography-ICP-DRC-MS for vanadate, expected to be the worst among all vanadium chemical species, was found to be 40 ng L-1 serum (or 4 pg V, 100 muL serum injected) and the repeatability 7\%. This on-line separation method was used in order to speciate vanadium in serum after incubation with vanadate, at a concentration level that is representative of the pharmacological concentration range of vanadium when used as an insulin-like agent.},
  author       = {Ch{\'e}ry, Cyrille C and De Cremer, Koen and Cornelis, Rita and Vanhaecke, Frank and Moens, Luc},
  issn         = {0267-9477},
  journal      = {JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY},
  keyword      = {TRACE-ELEMENTS,IONIZATION-ENERGY,IN-VIVO,RECOMMENDATIONS,SPECTRUM,PATTERNS,CLO,RAT},
  language     = {eng},
  location     = {Garmisch-Partenkirchen, Germany},
  number       = {9},
  pages        = {1113--1118},
  title        = {Optimisation of ICP-dynamic reaction cell-MS as specific detector for the speciation analysis of vanadium at therapeutic levels in serum},
  url          = {http://dx.doi.org/10.1039/b301682j},
  volume       = {18},
  year         = {2003},
}

Chicago
Chéry, Cyrille C, Koen De Cremer, Rita Cornelis, Frank Vanhaecke, and Luc Moens. 2003. “Optimisation of ICP-dynamic Reaction cell-MS as Specific Detector for the Speciation Analysis of Vanadium at Therapeutic Levels in Serum.” Journal of Analytical Atomic Spectrometry 18 (9): 1113–1118.
APA
Chéry, C. C., De Cremer, K., Cornelis, R., Vanhaecke, F., & Moens, L. (2003). Optimisation of ICP-dynamic reaction cell-MS as specific detector for the speciation analysis of vanadium at therapeutic levels in serum. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, 18(9), 1113–1118. Presented at the European winter conference on Plasma Spectrochemistry.
Vancouver
1.
Chéry CC, De Cremer K, Cornelis R, Vanhaecke F, Moens L. Optimisation of ICP-dynamic reaction cell-MS as specific detector for the speciation analysis of vanadium at therapeutic levels in serum. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY. 2003;18(9):1113–8.
MLA
Chéry, Cyrille C, Koen De Cremer, Rita Cornelis, et al. “Optimisation of ICP-dynamic Reaction cell-MS as Specific Detector for the Speciation Analysis of Vanadium at Therapeutic Levels in Serum.” JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY 18.9 (2003): 1113–1118. Print.