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Long-term follow-up of renal function in dogs after treatment for ACTH-dependent hyperadrenocorticism

Pascale Smets UGent, Hervé Lefebvre, BP Meij, Siska Croubels UGent, Evelyne Meyer UGent, Isabel Van de Maele UGent and Sylvie Daminet UGent (2012) JOURNAL OF VETERINARY INTERNAL MEDICINE. 26(3). p.565-574
abstract
Background : Systemic hypertension and proteinuria are frequent complications in dogs with Cushing's syndrome and do not always resolve after treatment of hypercortisolism. Therefore, dogs with Cushing's syndrome may be at risk for renal dysfunction before and after treatment. Hypothesis/Objectives : To assess renal function in dogs with ACTH-dependent hyperadrenocorticism (ADHAC) before and after treatment. Animals : A total of 19 dogs with ADHAC and 12 control dogs. Methods : Renal function was assessed before and at 1, 3, 6, and 12 similar to months after treatment. Twelve dogs were treated with trilostane and 7 dogs by transsphenoidal hypophysectomy. Routine renal markers were measured and urinary albumin (uALB), immunoglobulin G (uIgG), and retinol-binding protein (uRBP) were assessed by ELISA. Urinary N-acetyl-beta-D-glucosaminidase (uNAG) was determined colorimetrically. All urinary markers were indexed to urinary creatinine concentration (c). Plasma clearance of creatinine (Clcreat), exo-iohexol (Clexo), and endo-iohexol (Clendo) was used to measure glomerular filtration rate (GFR). Data were analyzed using a general linear model. Results : Serum creatinine and urea concentrations increased post-treatment, but remained within reference ranges. Plasma Clcreat and Clendo were significantly lower post-treatment, whereas Clexo was not different. Urinary protein-to-creatinine ratio (UPC), uALB/c, uIgG/c, and uRBP/c were decreased post-treatment, but at 12 similar to months 5/13 dogs remained proteinuric. Urinary NAG/c did not change significantly. Conclusions and clinical importance : A decrease in GFR and persistent proteinuria post-treatment may warrant the clinician's attention. Future research including renal histopathology of dogs with persistent proteinuria or low GFR is needed to further assess renal outcome.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
BETA-D-GLUCOSAMINIDASE, Cortisol, CUSHINGS-DISEASE, TRANSSPHENOIDAL HYPOPHYSECTOMY, EXOGENOUS CREATININE, TUBULAR DYSFUNCTION, BLOOD CONTAMINATION, DIABETES-MELLITUS, ARTERIAL-PRESSURE, CANINE URINE, dog, ACTH, renal function, Glomerular filtration rate, Proteinuria, Urinary marker, GLOMERULAR-FILTRATION-RATE
journal title
JOURNAL OF VETERINARY INTERNAL MEDICINE
J. Vet. Intern. Med.
volume
26
issue
3
pages
565 - 574
Web of Science type
Article
Web of Science id
000303496600016
JCR category
VETERINARY SCIENCES
JCR impact factor
2.064 (2012)
JCR rank
13/142 (2012)
JCR quartile
1 (2012)
ISSN
0891-6640
DOI
10.1111/j.1939-1676.2012.00915.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2114231
handle
http://hdl.handle.net/1854/LU-2114231
date created
2012-05-25 14:44:53
date last changed
2012-05-29 09:45:58
@article{2114231,
  abstract     = {Background : Systemic hypertension and proteinuria are frequent complications in dogs with Cushing's syndrome and do not always resolve after treatment of hypercortisolism. Therefore, dogs with Cushing's syndrome may be at risk for renal dysfunction before and after treatment.
Hypothesis/Objectives : To assess renal function in dogs with ACTH-dependent hyperadrenocorticism (ADHAC) before and after treatment.
Animals : A total of 19 dogs with ADHAC and 12 control dogs.
Methods : Renal function was assessed before and at 1, 3, 6, and 12 similar to months after treatment. Twelve dogs were treated with trilostane and 7 dogs by transsphenoidal hypophysectomy. Routine renal markers were measured and urinary albumin (uALB), immunoglobulin G (uIgG), and retinol-binding protein (uRBP) were assessed by ELISA. Urinary N-acetyl-beta-D-glucosaminidase (uNAG) was determined colorimetrically. All urinary markers were indexed to urinary creatinine concentration (c). Plasma clearance of creatinine (Clcreat), exo-iohexol (Clexo), and endo-iohexol (Clendo) was used to measure glomerular filtration rate (GFR). Data were analyzed using a general linear model.
Results : Serum creatinine and urea concentrations increased post-treatment, but remained within reference ranges. Plasma Clcreat and Clendo were significantly lower post-treatment, whereas Clexo was not different. Urinary protein-to-creatinine ratio (UPC), uALB/c, uIgG/c, and uRBP/c were decreased post-treatment, but at 12 similar to months 5/13 dogs remained proteinuric. Urinary NAG/c did not change significantly.
Conclusions and clinical importance : A decrease in GFR and persistent proteinuria post-treatment may warrant the clinician's attention. Future research including renal histopathology of dogs with persistent proteinuria or low GFR is needed to further assess renal outcome.},
  author       = {Smets, Pascale and Lefebvre, Herv{\'e} and Meij, BP and Croubels, Siska and Meyer, Evelyne and Van de Maele, Isabel and Daminet, Sylvie},
  issn         = {0891-6640},
  journal      = {JOURNAL OF VETERINARY INTERNAL MEDICINE},
  keyword      = {BETA-D-GLUCOSAMINIDASE,Cortisol,CUSHINGS-DISEASE,TRANSSPHENOIDAL HYPOPHYSECTOMY,EXOGENOUS CREATININE,TUBULAR DYSFUNCTION,BLOOD CONTAMINATION,DIABETES-MELLITUS,ARTERIAL-PRESSURE,CANINE URINE,dog,ACTH,renal function,Glomerular filtration rate,Proteinuria,Urinary marker,GLOMERULAR-FILTRATION-RATE},
  language     = {eng},
  number       = {3},
  pages        = {565--574},
  title        = {Long-term follow-up of renal function in dogs after treatment for ACTH-dependent hyperadrenocorticism},
  url          = {http://dx.doi.org/10.1111/j.1939-1676.2012.00915.x},
  volume       = {26},
  year         = {2012},
}

Chicago
Smets, Pascale, Hervé Lefebvre, BP Meij, Siska Croubels, Evelyne Meyer, Isabel Van de Maele, and Sylvie Daminet. 2012. “Long-term Follow-up of Renal Function in Dogs After Treatment for ACTH-dependent Hyperadrenocorticism.” Journal of Veterinary Internal Medicine 26 (3): 565–574.
APA
Smets, P., Lefebvre, H., Meij, B., Croubels, S., Meyer, E., Van de Maele, I., & Daminet, S. (2012). Long-term follow-up of renal function in dogs after treatment for ACTH-dependent hyperadrenocorticism. JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(3), 565–574.
Vancouver
1.
Smets P, Lefebvre H, Meij B, Croubels S, Meyer E, Van de Maele I, et al. Long-term follow-up of renal function in dogs after treatment for ACTH-dependent hyperadrenocorticism. JOURNAL OF VETERINARY INTERNAL MEDICINE. 2012;26(3):565–74.
MLA
Smets, Pascale, Hervé Lefebvre, BP Meij, et al. “Long-term Follow-up of Renal Function in Dogs After Treatment for ACTH-dependent Hyperadrenocorticism.” JOURNAL OF VETERINARY INTERNAL MEDICINE 26.3 (2012): 565–574. Print.