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Arabidopsis phosphatidylglycerophosphate synthase 1 is essential for chloroplast differentiation, but is dispensable for mitochondrial function

Elena Babiychuk UGent, Frank Müller, Holger Eubel, Hans-Peter Braun, Margrit Frentzen and Sergei Kushnir UGent (2003) PLANT JOURNAL. 33(5). p.899-909
abstract
Genetic dissection of the lipid bilayer composition provides essential in vivo evidence for the role of individual lipid species in membrane function. To understand the in vivo role of the anionic phospholipid, phosphatidylglycerol, the loss-of-function mutation was identified and characterized in the Arabidopsis thaliana gene coding for phosphatidylglycerophosphate synthase 1, PGP1. This mutation resulted in pigment-deficient plants of the xantha type in which the biogenesis of thylakoid membranes was severely compromised. The PGP1 gene coded for a precursor polypeptide that was targeted in vivo to both plastids and mitochondria. The activity of the plastidial PGP1 isoform was essential for the biosynthesis of phosphatidylglycerol in chloroplasts, whereas the mitochondrial PGP1 isoform was redundant for the accumulation of phosphatidylglycerol and its derivative cardiolipin in plant mitochondrial membranes. Together with findings in cyanobacteria, these data demonstrated that anionic phospholipids play an important, evolutionarily conserved role in the biogenesis and function of the photosynthetic machinery. In addition, mutant analysis suggested that in higher plants, mitochondria, unlike plastids, could import phosphatidylglycerol from the endoplasmic reticulum.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
cardiolipin, anionic phospholipids, membrane biogenesis, mitochondria, photosynthesis, plastids, LIGHT-HARVESTING COMPLEX, PHOTOSYSTEM-II, PLANT-MITOCHONDRIA, ANIONIC PHOSPHOLIPIDS, SPINACH-CHLOROPLASTS, SUSPENSION-CULTURES, ESCHERICHIA-COLI, NULL MUTANT, CARDIOLIPIN, THALIANA
journal title
PLANT JOURNAL
Plant J.
volume
33
issue
5
pages
899 - 909
Web of Science type
Article
Web of Science id
000181285900008
JCR category
PLANT SCIENCES
JCR impact factor
5.914 (2003)
JCR rank
6/136 (2003)
JCR quartile
1 (2003)
ISSN
0960-7412
DOI
10.1046/j.1365-313X.2003.01680.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
211336
handle
http://hdl.handle.net/1854/LU-211336
date created
2004-04-16 14:38:00
date last changed
2013-09-26 10:58:58
@article{211336,
  abstract     = {Genetic dissection of the lipid bilayer composition provides essential in vivo evidence for the role of individual lipid species in membrane function. To understand the in vivo role of the anionic phospholipid, phosphatidylglycerol, the loss-of-function mutation was identified and characterized in the Arabidopsis thaliana gene coding for phosphatidylglycerophosphate synthase 1, PGP1. This mutation resulted in pigment-deficient plants of the xantha type in which the biogenesis of thylakoid membranes was severely compromised. The PGP1 gene coded for a precursor polypeptide that was targeted in vivo to both plastids and mitochondria. The activity of the plastidial PGP1 isoform was essential for the biosynthesis of phosphatidylglycerol in chloroplasts, whereas the mitochondrial PGP1 isoform was redundant for the accumulation of phosphatidylglycerol and its derivative cardiolipin in plant mitochondrial membranes. Together with findings in cyanobacteria, these data demonstrated that anionic phospholipids play an important, evolutionarily conserved role in the biogenesis and function of the photosynthetic machinery. In addition, mutant analysis suggested that in higher plants, mitochondria, unlike plastids, could import phosphatidylglycerol from the endoplasmic reticulum.},
  author       = {Babiychuk, Elena and M{\"u}ller, Frank and Eubel, Holger and Braun, Hans-Peter and Frentzen, Margrit and Kushnir, Sergei},
  issn         = {0960-7412},
  journal      = {PLANT JOURNAL},
  keyword      = {cardiolipin,anionic phospholipids,membrane biogenesis,mitochondria,photosynthesis,plastids,LIGHT-HARVESTING COMPLEX,PHOTOSYSTEM-II,PLANT-MITOCHONDRIA,ANIONIC PHOSPHOLIPIDS,SPINACH-CHLOROPLASTS,SUSPENSION-CULTURES,ESCHERICHIA-COLI,NULL MUTANT,CARDIOLIPIN,THALIANA},
  language     = {eng},
  number       = {5},
  pages        = {899--909},
  title        = {Arabidopsis phosphatidylglycerophosphate synthase 1 is essential for chloroplast differentiation, but is dispensable for mitochondrial function},
  url          = {http://dx.doi.org/10.1046/j.1365-313X.2003.01680.x},
  volume       = {33},
  year         = {2003},
}

Chicago
Babiychuk, Elena, Frank Müller, Holger Eubel, Hans-Peter Braun, Margrit Frentzen, and Sergei Kushnir. 2003. “Arabidopsis Phosphatidylglycerophosphate Synthase 1 Is Essential for Chloroplast Differentiation, but Is Dispensable for Mitochondrial Function.” Plant Journal 33 (5): 899–909.
APA
Babiychuk, E., Müller, F., Eubel, H., Braun, H.-P., Frentzen, M., & Kushnir, S. (2003). Arabidopsis phosphatidylglycerophosphate synthase 1 is essential for chloroplast differentiation, but is dispensable for mitochondrial function. PLANT JOURNAL, 33(5), 899–909.
Vancouver
1.
Babiychuk E, Müller F, Eubel H, Braun H-P, Frentzen M, Kushnir S. Arabidopsis phosphatidylglycerophosphate synthase 1 is essential for chloroplast differentiation, but is dispensable for mitochondrial function. PLANT JOURNAL. 2003;33(5):899–909.
MLA
Babiychuk, Elena, Frank Müller, Holger Eubel, et al. “Arabidopsis Phosphatidylglycerophosphate Synthase 1 Is Essential for Chloroplast Differentiation, but Is Dispensable for Mitochondrial Function.” PLANT JOURNAL 33.5 (2003): 899–909. Print.