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Transfer of flubendazole and tylosin at cross contamination levels in the feed to egg matrices and distribution between egg yolk and egg white

Valerie Vandenberge, Evelyne Delezie, Philippe Delahaut, Gilles Pierret, Patrick De Backer UGent, Els Daeseleire and Siska Croubels UGent (2012) POULTRY SCIENCE. 91(5). p.1248-1255
abstract
Chemical residues may be present in eggs from laying hens' exposure to drugs or contaminants. These residues may pose risks to human health. In this study, laying hens received experimental feed containing flubendazole or tylosin at cross contamination levels of 2.5, 5, and 10% of the therapeutic dose. Eggs were collected daily and analysis of the whole egg, egg white, and egg yolk was performed using liquid chromatography tandem mass spectrometry. Highest concentrations of the parent molecule flubendazole, as well as the hydrolyzed and the reduced metabolite, were detected in egg yolk. Residue concentrations of the parent molecule were higher compared with those of the metabolites in all egg matrices. No tylosin residue concentrations were detected above the limit of quantification for all concentration groups and in all egg matrices. Neither molecule exceeded the set maximum residue limits.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PHARMACOKINETICS, RESIDUE DEPLETION, tylosin, feed, egg, cross contamination, MEDICINE, LIQUID-CHROMATOGRAPHY, VETERINARY DRUGS, LAYING HENS, flubendazole
journal title
POULTRY SCIENCE
Poult. Sci.
volume
91
issue
5
pages
1248 - 1255
Web of Science type
Article
Web of Science id
000302790500026
JCR category
AGRICULTURE, DAIRY & ANIMAL SCIENCE
JCR impact factor
1.516 (2012)
JCR rank
11/54 (2012)
JCR quartile
1 (2012)
ISSN
0032-5791
DOI
10.3382/ps.2011-02071
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2113287
handle
http://hdl.handle.net/1854/LU-2113287
date created
2012-05-25 14:37:19
date last changed
2016-12-19 15:42:54
@article{2113287,
  abstract     = {Chemical residues may be present in eggs from laying hens' exposure to drugs or contaminants. These residues may pose risks to human health. In this study, laying hens received experimental feed containing flubendazole or tylosin at cross contamination levels of 2.5, 5, and 10\% of the therapeutic dose. Eggs were collected daily and analysis of the whole egg, egg white, and egg yolk was performed using liquid chromatography tandem mass spectrometry. Highest concentrations of the parent molecule flubendazole, as well as the hydrolyzed and the reduced metabolite, were detected in egg yolk. Residue concentrations of the parent molecule were higher compared with those of the metabolites in all egg matrices. No tylosin residue concentrations were detected above the limit of quantification for all concentration groups and in all egg matrices. Neither molecule exceeded the set maximum residue limits.},
  author       = {Vandenberge, Valerie and Delezie, Evelyne and Delahaut, Philippe and Pierret, Gilles and De Backer, Patrick and Daeseleire, Els  and Croubels, Siska},
  issn         = {0032-5791},
  journal      = {POULTRY SCIENCE},
  keyword      = {PHARMACOKINETICS,RESIDUE DEPLETION,tylosin,feed,egg,cross contamination,MEDICINE,LIQUID-CHROMATOGRAPHY,VETERINARY DRUGS,LAYING HENS,flubendazole},
  language     = {eng},
  number       = {5},
  pages        = {1248--1255},
  title        = {Transfer of flubendazole and tylosin at cross contamination levels in the feed to egg matrices and distribution between egg yolk and egg white},
  url          = {http://dx.doi.org/10.3382/ps.2011-02071},
  volume       = {91},
  year         = {2012},
}

Chicago
Vandenberge, Valerie, Evelyne Delezie, Philippe Delahaut, Gilles Pierret, Patrick De Backer, Els Daeseleire, and Siska Croubels. 2012. “Transfer of Flubendazole and Tylosin at Cross Contamination Levels in the Feed to Egg Matrices and Distribution Between Egg Yolk and Egg White.” Poultry Science 91 (5): 1248–1255.
APA
Vandenberge, V., Delezie, E., Delahaut, P., Pierret, G., De Backer, P., Daeseleire, E., & Croubels, S. (2012). Transfer of flubendazole and tylosin at cross contamination levels in the feed to egg matrices and distribution between egg yolk and egg white. POULTRY SCIENCE, 91(5), 1248–1255.
Vancouver
1.
Vandenberge V, Delezie E, Delahaut P, Pierret G, De Backer P, Daeseleire E, et al. Transfer of flubendazole and tylosin at cross contamination levels in the feed to egg matrices and distribution between egg yolk and egg white. POULTRY SCIENCE. 2012;91(5):1248–55.
MLA
Vandenberge, Valerie, Evelyne Delezie, Philippe Delahaut, et al. “Transfer of Flubendazole and Tylosin at Cross Contamination Levels in the Feed to Egg Matrices and Distribution Between Egg Yolk and Egg White.” POULTRY SCIENCE 91.5 (2012): 1248–1255. Print.