Ghent University Academic Bibliography

Advanced

Simulated microgravity decreases apoptosis in fetal fibroblasts

Michaël Beck UGent, Kevin Tabury, Marjan Moreels, Paul Jacquet, Patric Van Oostveldt UGent, Winnok De Vos UGent and Sarah Baatout UGent (2012) INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 30(2). p.309-313
abstract
Space travel is a major challenge for human beings. Especially, the mechanisms through which space conditions might alter animal development have been questioned for a long time. The two major physical stress factors that are of relevance in this context are space radiation and weightlessness. While it has been extensively shown that high doses of ionizing radiation induce deleterious effects on embryonic development, so far, little is known about the potential harmful effects of radiation in combination with microgravity on the developing organism. In the present study, we investigated the effects of simulated microgravity on irradiated STO mouse fetal fibroblast cells using a random positioning machine (RPM). Radiation-induced cell cycle changes were not affected when cells were subjected to simulated microgravity for 24 h. Moreover, no morphological differences were observed in irradiated samples exposed to simulated microgravity compared to cells that were exclusively irradiated. However, microgravity simulation significantly decreased the level of apoptosis at all doses as measured by caspase-3 activity and it prevented cells from undergoing radiation-induced size increase up to 1 Gy.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
simulated microgravity, X-rays, fetal mouse fibroblasts, DNA damage, cell cycle arrest, apoptosis, RANDOM-POSITIONING MACHINE, IONIZING-RADIATION, CELLULAR-RESPONSE, X-IRRADIATION, DNA-REPAIR, CELLS, LYMPHOCYTES, SPACE, EXPRESSION
journal title
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Int. J. Mol. Med.
volume
30
issue
2
pages
309 - 313
Web of Science type
Article
Web of Science id
000306155400014
JCR category
MEDICINE, RESEARCH & EXPERIMENTAL
JCR impact factor
1.957 (2012)
JCR rank
73/119 (2012)
JCR quartile
3 (2012)
ISSN
1107-3756
DOI
10.3892/ijmm.2012.1001
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2112408
handle
http://hdl.handle.net/1854/LU-2112408
date created
2012-05-24 15:37:21
date last changed
2012-09-28 16:17:31
@article{2112408,
  abstract     = {Space travel is a major challenge for human beings. Especially, the mechanisms through which space conditions might alter animal development have been questioned for a long time. The two major physical stress factors that are of relevance in this context are space radiation and weightlessness. While it has been extensively shown that high doses of ionizing radiation induce deleterious effects on embryonic development, so far, little is known about the potential harmful effects of radiation in combination with microgravity on the developing organism. In the present study, we investigated the effects of simulated microgravity on irradiated STO mouse fetal fibroblast cells using a random positioning machine (RPM). Radiation-induced cell cycle changes were not affected when cells were subjected to simulated microgravity for 24 h. Moreover, no morphological differences were observed in irradiated samples exposed to simulated microgravity compared to cells that were exclusively irradiated. However, microgravity simulation significantly decreased the level of apoptosis at all doses as measured by caspase-3 activity and it prevented cells from undergoing radiation-induced size increase up to 1 Gy.},
  author       = {Beck, Micha{\"e}l and Tabury, Kevin and Moreels, Marjan and Jacquet, Paul and Van Oostveldt, Patric and De Vos, Winnok and Baatout, Sarah},
  issn         = {1107-3756},
  journal      = {INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE},
  keyword      = {simulated microgravity,X-rays,fetal mouse fibroblasts,DNA damage,cell cycle arrest,apoptosis,RANDOM-POSITIONING MACHINE,IONIZING-RADIATION,CELLULAR-RESPONSE,X-IRRADIATION,DNA-REPAIR,CELLS,LYMPHOCYTES,SPACE,EXPRESSION},
  language     = {eng},
  number       = {2},
  pages        = {309--313},
  title        = {Simulated microgravity decreases apoptosis in fetal fibroblasts},
  url          = {http://dx.doi.org/10.3892/ijmm.2012.1001},
  volume       = {30},
  year         = {2012},
}

Chicago
Beck, Michaël, Kevin Tabury, Marjan Moreels, Paul Jacquet, Patric Van Oostveldt, Winnok De Vos, and Sarah Baatout. 2012. “Simulated Microgravity Decreases Apoptosis in Fetal Fibroblasts.” International Journal of Molecular Medicine 30 (2): 309–313.
APA
Beck, Michaël, Tabury, K., Moreels, M., Jacquet, P., Van Oostveldt, P., De Vos, W., & Baatout, S. (2012). Simulated microgravity decreases apoptosis in fetal fibroblasts. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 30(2), 309–313.
Vancouver
1.
Beck M, Tabury K, Moreels M, Jacquet P, Van Oostveldt P, De Vos W, et al. Simulated microgravity decreases apoptosis in fetal fibroblasts. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2012;30(2):309–13.
MLA
Beck, Michaël, Kevin Tabury, Marjan Moreels, et al. “Simulated Microgravity Decreases Apoptosis in Fetal Fibroblasts.” INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 30.2 (2012): 309–313. Print.