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Diverse microbial interactions with the basement membrane barrier

Lennert Steukers (UGent) , Sarah Glorieux (UGent) , Annelies Vandekerckhove (UGent) , Herman Favoreel (UGent) and Hans Nauwynck (UGent)
(2012) TRENDS IN MICROBIOLOGY. 20(3). p.147-155
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Abstract
During primary contact with susceptible hosts, microorganisms face an array of barriers that thwart their invasion process. Passage through the basement membrane (BM), a 50-100-nm-thick crucial barrier underlying epithelia and endothelia, is a prerequisite for successful host invasion. Such passage allows pathogens to reach nerve endings or blood vessels in the stroma and to facilitate spread to internal organs. During evolution, several pathogens have developed different mechanisms to cross this dense matrix of sheet-like proteins. To breach the BM, some microorganisms have developed independent mechanisms, others hijack host cells that are able to transverse the BM (e.g. leukocytes and dendritic cells) and oncogenic microorganisms might even trigger metastatic processes in epithelial cells to penetrate the underlying BM.
Keywords
CANDIDA-ALBICANS, PARACOCCIDIOIDES-BRASILIENSIS, EXTRACELLULAR-MATRIX PROTEINS, SURFACE-PROTEINS, DENDRITIC CELLS, BACTERIAL ADHESINS, MONOCYTES-MACROPHAGES, INTRACELLULAR PATHOGENS, HAEMOPHILUS-INFLUENZAE, HELICOBACTER-PYLORI

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Chicago
Steukers, Lennert, Sarah Glorieux, Annelies Vandekerckhove, Herman Favoreel, and Hans Nauwynck. 2012. “Diverse Microbial Interactions with the Basement Membrane Barrier.” Trends in Microbiology 20 (3): 147–155.
APA
Steukers, L., Glorieux, S., Vandekerckhove, A., Favoreel, H., & Nauwynck, H. (2012). Diverse microbial interactions with the basement membrane barrier. TRENDS IN MICROBIOLOGY, 20(3), 147–155.
Vancouver
1.
Steukers L, Glorieux S, Vandekerckhove A, Favoreel H, Nauwynck H. Diverse microbial interactions with the basement membrane barrier. TRENDS IN MICROBIOLOGY. 2012;20(3):147–55.
MLA
Steukers, Lennert, Sarah Glorieux, Annelies Vandekerckhove, et al. “Diverse Microbial Interactions with the Basement Membrane Barrier.” TRENDS IN MICROBIOLOGY 20.3 (2012): 147–155. Print.
@article{2112296,
  abstract     = {During primary contact with susceptible hosts, microorganisms face an array of barriers that thwart their invasion process. Passage through the basement membrane (BM), a 50-100-nm-thick crucial barrier underlying epithelia and endothelia, is a prerequisite for successful host invasion. Such passage allows pathogens to reach nerve endings or blood vessels in the stroma and to facilitate spread to internal organs. During evolution, several pathogens have developed different mechanisms to cross this dense matrix of sheet-like proteins. To breach the BM, some microorganisms have developed independent mechanisms, others hijack host cells that are able to transverse the BM (e.g. leukocytes and dendritic cells) and oncogenic microorganisms might even trigger metastatic processes in epithelial cells to penetrate the underlying BM.},
  author       = {Steukers, Lennert and Glorieux, Sarah and Vandekerckhove, Annelies and Favoreel, Herman and Nauwynck, Hans},
  issn         = {0966-842X},
  journal      = {TRENDS IN MICROBIOLOGY},
  keyword      = {CANDIDA-ALBICANS,PARACOCCIDIOIDES-BRASILIENSIS,EXTRACELLULAR-MATRIX PROTEINS,SURFACE-PROTEINS,DENDRITIC CELLS,BACTERIAL ADHESINS,MONOCYTES-MACROPHAGES,INTRACELLULAR PATHOGENS,HAEMOPHILUS-INFLUENZAE,HELICOBACTER-PYLORI},
  language     = {eng},
  number       = {3},
  pages        = {147--155},
  title        = {Diverse microbial interactions with the basement membrane barrier},
  url          = {http://dx.doi.org/10.1016/j.tim.2012.01.001},
  volume       = {20},
  year         = {2012},
}

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