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Diverse microbial interactions with the basement membrane barrier

Lennert Steukers UGent, SARAH GLORIEUX UGent, Annelies Vandekerckhove UGent, Herman Favoreel UGent and Hans Nauwynck UGent (2012) TRENDS IN MICROBIOLOGY. 20(3). p.147-155
abstract
During primary contact with susceptible hosts, microorganisms face an array of barriers that thwart their invasion process. Passage through the basement membrane (BM), a 50-100-nm-thick crucial barrier underlying epithelia and endothelia, is a prerequisite for successful host invasion. Such passage allows pathogens to reach nerve endings or blood vessels in the stroma and to facilitate spread to internal organs. During evolution, several pathogens have developed different mechanisms to cross this dense matrix of sheet-like proteins. To breach the BM, some microorganisms have developed independent mechanisms, others hijack host cells that are able to transverse the BM (e.g. leukocytes and dendritic cells) and oncogenic microorganisms might even trigger metastatic processes in epithelial cells to penetrate the underlying BM.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
CANDIDA-ALBICANS, PARACOCCIDIOIDES-BRASILIENSIS, EXTRACELLULAR-MATRIX PROTEINS, SURFACE-PROTEINS, DENDRITIC CELLS, BACTERIAL ADHESINS, MONOCYTES-MACROPHAGES, INTRACELLULAR PATHOGENS, HAEMOPHILUS-INFLUENZAE, HELICOBACTER-PYLORI
journal title
TRENDS IN MICROBIOLOGY
Trends Microbiol.
volume
20
issue
3
pages
147 - 155
Web of Science type
Review
Web of Science id
000302455600007
JCR category
MICROBIOLOGY
JCR impact factor
8.434 (2012)
JCR rank
9/116 (2012)
JCR quartile
1 (2012)
ISSN
0966-842X
DOI
10.1016/j.tim.2012.01.001
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2112296
handle
http://hdl.handle.net/1854/LU-2112296
date created
2012-05-24 14:10:37
date last changed
2012-05-25 10:59:32
@article{2112296,
  abstract     = {During primary contact with susceptible hosts, microorganisms face an array of barriers that thwart their invasion process. Passage through the basement membrane (BM), a 50-100-nm-thick crucial barrier underlying epithelia and endothelia, is a prerequisite for successful host invasion. Such passage allows pathogens to reach nerve endings or blood vessels in the stroma and to facilitate spread to internal organs. During evolution, several pathogens have developed different mechanisms to cross this dense matrix of sheet-like proteins. To breach the BM, some microorganisms have developed independent mechanisms, others hijack host cells that are able to transverse the BM (e.g. leukocytes and dendritic cells) and oncogenic microorganisms might even trigger metastatic processes in epithelial cells to penetrate the underlying BM.},
  author       = {Steukers, Lennert and GLORIEUX, SARAH and Vandekerckhove, Annelies and Favoreel, Herman and Nauwynck, Hans},
  issn         = {0966-842X},
  journal      = {TRENDS IN MICROBIOLOGY},
  keyword      = {CANDIDA-ALBICANS,PARACOCCIDIOIDES-BRASILIENSIS,EXTRACELLULAR-MATRIX PROTEINS,SURFACE-PROTEINS,DENDRITIC CELLS,BACTERIAL ADHESINS,MONOCYTES-MACROPHAGES,INTRACELLULAR PATHOGENS,HAEMOPHILUS-INFLUENZAE,HELICOBACTER-PYLORI},
  language     = {eng},
  number       = {3},
  pages        = {147--155},
  title        = {Diverse microbial interactions with the basement membrane barrier},
  url          = {http://dx.doi.org/10.1016/j.tim.2012.01.001},
  volume       = {20},
  year         = {2012},
}

Chicago
Steukers, Lennert, Sarah Glorieux, Annelies Vandekerckhove, Herman Favoreel, and Hans Nauwynck. 2012. “Diverse Microbial Interactions with the Basement Membrane Barrier.” Trends in Microbiology 20 (3): 147–155.
APA
Steukers, L., Glorieux, S., Vandekerckhove, A., Favoreel, H., & Nauwynck, H. (2012). Diverse microbial interactions with the basement membrane barrier. TRENDS IN MICROBIOLOGY, 20(3), 147–155.
Vancouver
1.
Steukers L, Glorieux S, Vandekerckhove A, Favoreel H, Nauwynck H. Diverse microbial interactions with the basement membrane barrier. TRENDS IN MICROBIOLOGY. 2012;20(3):147–55.
MLA
Steukers, Lennert, Sarah Glorieux, Annelies Vandekerckhove, et al. “Diverse Microbial Interactions with the Basement Membrane Barrier.” TRENDS IN MICROBIOLOGY 20.3 (2012): 147–155. Print.