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Toxicity and mode of action of fungal lectins in pest insects important in agriculture

Mohamad Hamshou UGent (2012)
abstract
The urgent need for more and safer agricultural products, especially food, is rapidly increasing due to an increase of the global human population. Agriculture has suffered from multiple problems, a major threat being insects. These insects have been controlled with different methods mainly by using chemical insecticides. But many problems are associated with the use of these insecticides pushed entomologists to develop alternative methods for these chemical insecticides. Many plant lectins have been reported to possess insecticidal properties but very little is known about the entomotoxic effects of fungal lectins. The main objective of this PhD thesis is to study the insecticidal activity of fungal lectins isolated from two basidiomycetes namely Rhizoctonia solani and Sclerotinia sclerotiorum towards different pest insects and insect cell lines and to investigate the mode of action of these lectins. In vivo assays showed that these lectins have strong insecticidal activity towards pea aphid (Acyrthosiphon pisum) and cotton leafworm (Spodoptera littoralis). While in vitro assays using insect cell lines showed that the activity of these lectins depends on apoptosis induction or inhibition of cell proliferation. These findings suggest that fungal lectins are interesting tool that can be used for bioengineering insect resistance in important agronomical crops.
Please use this url to cite or link to this publication:
author
promoter
UGent and UGent
organization
year
type
dissertation (monograph)
subject
keyword
cytotoxicity, Funagl lectins, insecticide, biocontrol, pea aphid, cotton leafworm, antiproliferative, apoptosis
pages
239 pages
publisher
Ghent University. Faculty of Bioscience Engineering
place of publication
Ghent, Belgium
defense location
Gent : Faculteit Bio-ingenieurswetenschappen (A0.030)
defense date
2012-05-24 14:00
ISBN
9789059895256
language
English
UGent publication?
yes
classification
D1
additional info
dissertation consists of copyrighted material
copyright statement
I have transferred the copyright for this publication to the publisher
id
2110946
handle
http://hdl.handle.net/1854/LU-2110946
date created
2012-05-22 14:19:01
date last changed
2012-05-23 08:53:24
@phdthesis{2110946,
  abstract     = {The urgent need for more and safer agricultural products, especially food, is rapidly increasing due to an increase of the global human population. Agriculture has suffered from multiple problems, a major threat being insects. These insects have been controlled with different methods mainly by using chemical insecticides. But many problems are associated with the use of these insecticides pushed entomologists to develop alternative methods for these chemical insecticides. Many plant lectins have been reported to possess insecticidal properties but very little is known about the entomotoxic effects of fungal lectins.
The main objective of this PhD thesis is to study the insecticidal activity of fungal lectins isolated from two basidiomycetes namely Rhizoctonia solani and Sclerotinia sclerotiorum towards different pest insects and insect cell lines and to investigate the mode of action of these lectins. 
In vivo assays showed that these lectins have strong insecticidal activity towards pea aphid (Acyrthosiphon pisum) and cotton leafworm (Spodoptera littoralis). While in vitro assays using insect cell lines showed that the activity of these lectins depends on apoptosis induction or inhibition of cell proliferation. These  findings  suggest  that  fungal lectins  are  interesting  tool  that  can  be  used  for bioengineering insect resistance in important agronomical crops.},
  author       = {Hamshou, Mohamad},
  isbn         = {9789059895256},
  keyword      = {cytotoxicity,Funagl lectins,insecticide,biocontrol,pea aphid,cotton leafworm,antiproliferative,apoptosis},
  language     = {eng},
  pages        = {239},
  publisher    = {Ghent University. Faculty of Bioscience Engineering},
  school       = {Ghent University},
  title        = {Toxicity and mode of action of fungal lectins in pest insects important in agriculture},
  year         = {2012},
}

Chicago
Hamshou, Mohamad. 2012. “Toxicity and Mode of Action of Fungal Lectins in Pest Insects Important in Agriculture”. Ghent, Belgium: Ghent University. Faculty of Bioscience Engineering.
APA
Hamshou, M. (2012). Toxicity and mode of action of fungal lectins in pest insects important in agriculture. Ghent University. Faculty of Bioscience Engineering, Ghent, Belgium.
Vancouver
1.
Hamshou M. Toxicity and mode of action of fungal lectins in pest insects important in agriculture. [Ghent, Belgium]: Ghent University. Faculty of Bioscience Engineering; 2012.
MLA
Hamshou, Mohamad. “Toxicity and Mode of Action of Fungal Lectins in Pest Insects Important in Agriculture.” 2012 : n. pag. Print.