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ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value

Jo Vandesompele UGent, Anders Edsjö, Katleen De Preter UGent, Håkan Axelson, Franki Speleman UGent and Sven Påhlman (2003) ONCOGENE. 22(3). p.456-460
abstract
The MYCN proto-oncogene is frequently amplified in a subgroup of highly aggressive neuroblastomas. The molecular mechanism(s) by which the overexpressed MYCN contributes to an aggressive tumor cell behavior is not well understood. Recently, it was reported that the ID2 gene is a direct target for the MYCN and MYC transcription factors, and that ID2 expression and MYCN amplification correlate positively in neuroblastoma. In addition, ID2 expression was proposed as a negative prognostic parameter. As these results are of potential clinical importance, but not in agreement with our own initial observations, the putative correlation between ID2 and MYC(N) expression in neuroblastoma cell lines and tumors was reinvestigated. We found no correlation between MYCN and ID2 expression in neuroblastoma cell lines or tumor specimens. However, we did find a significant positive correlation between MYC and ID2 expressions in both MYCN-amplified and single-copy tumor specimens, and in MYCN single-copy cell lines. As previously reported, we also found an inverse correlation between MYC and MYCN expressions. Importantly, we could not confirm the reported prognostic power of ID2-expression in neuroblastoma. These data, obtained in two independent laboratories, challenge the previously proposed ID2-MYCN relation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ID2, MYC, MYCN, neuroblastoma, prognosis, N-MYC, NEURONAL DIFFERENTIATION, GENE-EXPRESSION, CELLS, PROTEINS, PCR
journal title
ONCOGENE
Oncogene
volume
22
issue
3
pages
456 - 460
Web of Science type
Article
Web of Science id
000180379100015
JCR category
ONCOLOGY
JCR impact factor
6.495 (2003)
JCR rank
12/117 (2003)
JCR quartile
1 (2003)
ISSN
0950-9232
DOI
10.1038/sj.onc.1206148
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
210779
handle
http://hdl.handle.net/1854/LU-210779
date created
2004-04-14 23:48:00
date last changed
2016-12-19 15:38:14
@article{210779,
  abstract     = {The MYCN proto-oncogene is frequently amplified in a subgroup of highly aggressive neuroblastomas. The molecular mechanism(s) by which the overexpressed MYCN contributes to an aggressive tumor cell behavior is not well understood. Recently, it was reported that the ID2 gene is a direct target for the MYCN and MYC transcription factors, and that ID2 expression and MYCN amplification correlate positively in neuroblastoma. In addition, ID2 expression was proposed as a negative prognostic parameter. As these results are of potential clinical importance, but not in agreement with our own initial observations, the putative correlation between ID2 and MYC(N) expression in neuroblastoma cell lines and tumors was reinvestigated. We found no correlation between MYCN and ID2 expression in neuroblastoma cell lines or tumor specimens. However, we did find a significant positive correlation between MYC and ID2 expressions in both MYCN-amplified and single-copy tumor specimens, and in MYCN single-copy cell lines. As previously reported, we also found an inverse correlation between MYC and MYCN expressions. Importantly, we could not confirm the reported prognostic power of ID2-expression in neuroblastoma. These data, obtained in two independent laboratories, challenge the previously proposed ID2-MYCN relation.},
  author       = {Vandesompele, Jo and Edsj{\"o}, Anders and De Preter, Katleen and Axelson, H{\aa}kan and Speleman, Franki and P{\aa}hlman, Sven},
  issn         = {0950-9232},
  journal      = {ONCOGENE},
  keyword      = {ID2,MYC,MYCN,neuroblastoma,prognosis,N-MYC,NEURONAL DIFFERENTIATION,GENE-EXPRESSION,CELLS,PROTEINS,PCR},
  language     = {eng},
  number       = {3},
  pages        = {456--460},
  title        = {ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value},
  url          = {http://dx.doi.org/10.1038/sj.onc.1206148},
  volume       = {22},
  year         = {2003},
}

Chicago
Vandesompele, Jo, Anders Edsjö, Katleen De Preter, Håkan Axelson, Franki Speleman, and Sven Påhlman. 2003. “ID2 Expression in Neuroblastoma Does Not Correlate to MYCN Levels and Lacks Prognostic Value.” Oncogene 22 (3): 456–460.
APA
Vandesompele, J., Edsjö, A., De Preter, K., Axelson, H., Speleman, F., & Påhlman, S. (2003). ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value. ONCOGENE, 22(3), 456–460.
Vancouver
1.
Vandesompele J, Edsjö A, De Preter K, Axelson H, Speleman F, Påhlman S. ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value. ONCOGENE. 2003;22(3):456–60.
MLA
Vandesompele, Jo, Anders Edsjö, Katleen De Preter, et al. “ID2 Expression in Neuroblastoma Does Not Correlate to MYCN Levels and Lacks Prognostic Value.” ONCOGENE 22.3 (2003): 456–460. Print.