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Progressive multifocal leukoencephalopathy in liver transplant recipients : a case report and review of the literature

(2011) TRANSPLANT INTERNATIONAL. 24(4). p.e30-e34
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Abstract
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the reactivation of the JC polyomavirus in immunocompromised patients. We report a case of PML in a liver transplant recipient and review the other published cases. The clinical course of PML is characterised by a rapid progressive neurological decline coinciding with the presence of white matter lesions on magnetic resonance images. There is no direct antiviral therapy available against the JC polyomavirus. Restoration of the immune response achieved by tapering or terminating the immunosuppressive regimen is the mainstay of treatment at present in transplanted patients. The prognosis remains, however, extremely poor regardless of treatment.
Keywords
liver transplantation, immunosuppression, progressive multifocal leukoencephalopathy, JC VIRUS, BRAIN, DNA, COMPLICATIONS, CHILDREN, INFECTION

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Citation

Please use this url to cite or link to this publication:

Chicago
Verhelst, Xavier, Geert Vanhooren, Ludo Vanopdenbosch, Jan Casselman, Wim Laleman, Jacques Pirenne, Frederik Nevens, and Hans Orlent. 2011. “Progressive Multifocal Leukoencephalopathy in Liver Transplant Recipients : a Case Report and Review of the Literature.” Transplant International 24 (4): e30–e34.
APA
Verhelst, X., Vanhooren, G., Vanopdenbosch, L., Casselman, J., Laleman, W., Pirenne, J., Nevens, F., et al. (2011). Progressive multifocal leukoencephalopathy in liver transplant recipients : a case report and review of the literature. TRANSPLANT INTERNATIONAL, 24(4), e30–e34.
Vancouver
1.
Verhelst X, Vanhooren G, Vanopdenbosch L, Casselman J, Laleman W, Pirenne J, et al. Progressive multifocal leukoencephalopathy in liver transplant recipients : a case report and review of the literature. TRANSPLANT INTERNATIONAL. 2011;24(4):e30–e34.
MLA
Verhelst, Xavier, Geert Vanhooren, Ludo Vanopdenbosch, et al. “Progressive Multifocal Leukoencephalopathy in Liver Transplant Recipients : a Case Report and Review of the Literature.” TRANSPLANT INTERNATIONAL 24.4 (2011): e30–e34. Print.
@article{2106814,
  abstract     = {Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the reactivation of the JC polyomavirus in immunocompromised patients. We report a case of PML in a liver transplant recipient and review the other published cases. The clinical course of PML is characterised by a rapid progressive neurological decline coinciding with the presence of white matter lesions on magnetic resonance images. There is no direct antiviral therapy available against the JC polyomavirus. Restoration of the immune response achieved by tapering or terminating the immunosuppressive regimen is the mainstay of treatment at present in transplanted patients. The prognosis remains, however, extremely poor regardless of treatment.},
  author       = {Verhelst, Xavier and Vanhooren, Geert and Vanopdenbosch, Ludo and Casselman, Jan and Laleman, Wim and Pirenne, Jacques and Nevens, Frederik and Orlent, Hans},
  issn         = {0934-0874},
  journal      = {TRANSPLANT INTERNATIONAL},
  keyword      = {liver transplantation,immunosuppression,progressive multifocal leukoencephalopathy,JC VIRUS,BRAIN,DNA,COMPLICATIONS,CHILDREN,INFECTION},
  language     = {eng},
  number       = {4},
  pages        = {e30--e34},
  title        = {Progressive multifocal leukoencephalopathy in liver transplant recipients : a case report and review of the literature},
  url          = {http://dx.doi.org/10.1111/j.1432-2277.2010.01190.x},
  volume       = {24},
  year         = {2011},
}

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