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Progressive multifocal leukoencephalopathy in liver transplant recipients: a case report and review of the literature

Xavier Verhelst UGent, Geert Vanhooren, Ludo Vanopdenbosch, Jan Casselman UGent, Wim Laleman, Jacques Pirenne, Frederik Nevens and Hans Orlent (2011) TRANSPLANT INTERNATIONAL. 24(4). p.e30-e34
abstract
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the reactivation of the JC polyomavirus in immunocompromised patients. We report a case of PML in a liver transplant recipient and review the other published cases. The clinical course of PML is characterised by a rapid progressive neurological decline coinciding with the presence of white matter lesions on magnetic resonance images. There is no direct antiviral therapy available against the JC polyomavirus. Restoration of the immune response achieved by tapering or terminating the immunosuppressive regimen is the mainstay of treatment at present in transplanted patients. The prognosis remains, however, extremely poor regardless of treatment.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
liver transplantation, immunosuppression, progressive multifocal leukoencephalopathy, JC VIRUS, BRAIN, DNA, COMPLICATIONS, CHILDREN, INFECTION
journal title
TRANSPLANT INTERNATIONAL
Transpl. Int.
volume
24
issue
4
issue title
Special focus: Global strategies to meet the organ need
pages
e30 - e34
Web of Science type
Article
Web of Science id
000288210800001
JCR category
SURGERY
JCR impact factor
2.921 (2011)
JCR rank
26/198 (2011)
JCR quartile
1 (2011)
ISSN
0934-0874
DOI
10.1111/j.1432-2277.2010.01190.x
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2106814
handle
http://hdl.handle.net/1854/LU-2106814
date created
2012-05-15 11:13:59
date last changed
2012-06-08 13:51:57
@article{2106814,
  abstract     = {Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the reactivation of the JC polyomavirus in immunocompromised patients. We report a case of PML in a liver transplant recipient and review the other published cases. The clinical course of PML is characterised by a rapid progressive neurological decline coinciding with the presence of white matter lesions on magnetic resonance images. There is no direct antiviral therapy available against the JC polyomavirus. Restoration of the immune response achieved by tapering or terminating the immunosuppressive regimen is the mainstay of treatment at present in transplanted patients. The prognosis remains, however, extremely poor regardless of treatment.},
  author       = {Verhelst, Xavier and Vanhooren, Geert and Vanopdenbosch, Ludo and Casselman, Jan and Laleman, Wim and Pirenne, Jacques and Nevens, Frederik and Orlent, Hans},
  issn         = {0934-0874},
  journal      = {TRANSPLANT INTERNATIONAL},
  keyword      = {liver transplantation,immunosuppression,progressive multifocal leukoencephalopathy,JC VIRUS,BRAIN,DNA,COMPLICATIONS,CHILDREN,INFECTION},
  language     = {eng},
  number       = {4},
  pages        = {e30--e34},
  title        = {Progressive multifocal leukoencephalopathy in liver transplant recipients: a case report and review of the literature},
  url          = {http://dx.doi.org/10.1111/j.1432-2277.2010.01190.x},
  volume       = {24},
  year         = {2011},
}

Chicago
Verhelst, Xavier, Geert Vanhooren, Ludo Vanopdenbosch, Jan Casselman, Wim Laleman, Jacques Pirenne, Frederik Nevens, and Hans Orlent. 2011. “Progressive Multifocal Leukoencephalopathy in Liver Transplant Recipients: a Case Report and Review of the Literature.” Transplant International 24 (4): e30–e34.
APA
Verhelst, X., Vanhooren, G., Vanopdenbosch, L., Casselman, J., Laleman, W., Pirenne, J., Nevens, F., et al. (2011). Progressive multifocal leukoencephalopathy in liver transplant recipients: a case report and review of the literature. TRANSPLANT INTERNATIONAL, 24(4), e30–e34.
Vancouver
1.
Verhelst X, Vanhooren G, Vanopdenbosch L, Casselman J, Laleman W, Pirenne J, et al. Progressive multifocal leukoencephalopathy in liver transplant recipients: a case report and review of the literature. TRANSPLANT INTERNATIONAL. 2011;24(4):e30–e34.
MLA
Verhelst, Xavier, Geert Vanhooren, Ludo Vanopdenbosch, et al. “Progressive Multifocal Leukoencephalopathy in Liver Transplant Recipients: a Case Report and Review of the Literature.” TRANSPLANT INTERNATIONAL 24.4 (2011): e30–e34. Print.