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Modeling the impact of partial hepatectomy on the hepatic hemodynamics using a rat model

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Abstract
Due to the growing shortage of donor livers, more patients are waiting for transplantation. Living donor liver transplantation may help expanding the donor pool, but is often confronted with the small-for-size syndrome. Since the hemodynamic effects of partial hepatectomy are not fully understood, we developed an electrical rat liver model to compare normal with resected liver hemodynamics. Detailed geometrical data and 3D reconstructions of the liver vasculature of two rats were gathered by combining vascular corrosion casting, micro-CT scanning and image processing. Data extrapolations allowed obtaining a total liver pressure- and flow-driven electrical analogue. Subsequently, virtual resections led to 70%, 80% or 90% partial hepatectomy models. Results demonstrated hyperperfusion effects such as portal hypertension and elevated lobe-specific portal venous flows (11 mmHg, 12 mmHg, 24 mmHg and 1.0-3.0 ml/min, 1.8-3.5 ml/min, 7.4 ml/min for 70%, 80%, 90% hepatectomy, respectively). Comparison of two 90% resection techniques demonstrated different total arterial flows (0.28 ml/min versus 0.61 ml/min), portal (24 mmHg versus 21 mmHg) and sinusoidal pressures (14 mmHg versus 9.5- 12 mmHg), probably leading to better survival for lower portal and sinusoidal pressures. Towards the future, the models may be extrapolated to human livers and help to optimize hepatectomy planning.
Keywords
REGENERATION, VASCULATURE, SHEAR-STRESS, FOR-SIZE GRAFTS, DONOR LIVER-TRANSPLANTATION, liver, fluid dynamics, biological system modeling, Biomedical engineering, biomedical image processing, PERFUSION, RESECTION, RESISTANCE, PRESSURE, SURVIVAL

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Chicago
Debbaut, Charlotte, David De Wilde, Christophe Casteleyn, Pieter Cornillie, Denis Van Loo, Luc Van Hoorebeke, Diethard Monbaliu, Ye-Dong Fan, and Patrick Segers. 2012. “Modeling the Impact of Partial Hepatectomy on the Hepatic Hemodynamics Using a Rat Model.” Ieee Transactions on Biomedical Engineering 59 (12): 3293–3303.
APA
Debbaut, C., De Wilde, D., Casteleyn, C., Cornillie, P., Van Loo, D., Van Hoorebeke, L., Monbaliu, D., et al. (2012). Modeling the impact of partial hepatectomy on the hepatic hemodynamics using a rat model. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 59(12), 3293–3303.
Vancouver
1.
Debbaut C, De Wilde D, Casteleyn C, Cornillie P, Van Loo D, Van Hoorebeke L, et al. Modeling the impact of partial hepatectomy on the hepatic hemodynamics using a rat model. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. 2012;59(12):3293–303.
MLA
Debbaut, Charlotte, David De Wilde, Christophe Casteleyn, et al. “Modeling the Impact of Partial Hepatectomy on the Hepatic Hemodynamics Using a Rat Model.” IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 59.12 (2012): 3293–3303. Print.
@article{2106059,
  abstract     = {Due to the growing shortage of donor livers, more patients are waiting for transplantation. Living donor liver transplantation may help expanding the donor pool, but is often confronted with the small-for-size syndrome. Since the hemodynamic effects of partial hepatectomy are not fully understood, we developed an electrical rat liver model to compare normal with resected liver hemodynamics. Detailed geometrical data and 3D reconstructions of the liver vasculature of two rats were gathered by combining vascular corrosion casting, micro-CT scanning and image processing. Data extrapolations allowed obtaining a total liver pressure- and flow-driven electrical analogue. Subsequently, virtual resections led to 70\%, 80\% or 90\% partial hepatectomy models. Results demonstrated hyperperfusion effects such as portal hypertension and elevated lobe-specific portal venous flows (11 mmHg, 12 mmHg, 24 mmHg and 1.0-3.0 ml/min, 1.8-3.5 ml/min, 7.4 ml/min for 70\%, 80\%, 90\% hepatectomy, respectively). Comparison of two 90\% resection techniques demonstrated different total arterial flows (0.28 ml/min versus 0.61 ml/min), portal (24 mmHg versus 21 mmHg) and sinusoidal pressures (14 mmHg versus 9.5- 12 mmHg), probably leading to better survival for lower portal and sinusoidal pressures. Towards the future, the models may be extrapolated to human livers and help to optimize hepatectomy planning.},
  author       = {Debbaut, Charlotte and De Wilde, David and Casteleyn, Christophe and Cornillie, Pieter and Van Loo, Denis and Van Hoorebeke, Luc and Monbaliu, Diethard and Fan, Ye-Dong and Segers, Patrick},
  issn         = {0018-9294},
  journal      = {IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING},
  keyword      = {REGENERATION,VASCULATURE,SHEAR-STRESS,FOR-SIZE GRAFTS,DONOR LIVER-TRANSPLANTATION,liver,fluid dynamics,biological system modeling,Biomedical engineering,biomedical image processing,PERFUSION,RESECTION,RESISTANCE,PRESSURE,SURVIVAL},
  language     = {eng},
  number       = {12},
  pages        = {3293--3303},
  title        = {Modeling the impact of partial hepatectomy on the hepatic hemodynamics using a rat model},
  url          = {http://dx.doi.org/10.1109/TBME.2012.2199108},
  volume       = {59},
  year         = {2012},
}

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